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| 1 | Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers:comparison between recurrent acute and chronic pancreatitis显示文摘BACKGROUND: Diagnostic parameters that can predict the presence of chronic pancreatitis(CP) in patients with recurrent pain due to pancreatitis would help to direct appropriate therapy. This study aimed to compare the serum levels of monocyte chemoattractant protein-1(MCP-1), transforming growth factor-β1(TGF-β1), nerve growth factor(NGF), resistin and hyaluronic acid(HA) in patients with recurrent acute pancreatitis(RAP) and CP to assess their ability to differentiate the two conditions.METHODS: Levels of serum markers assessed by enzymelinked immunosorbent assay(ELISA) were prospectively compared in consecutive patients with RAP, CP and in controls and stepwise discriminant analysis was performed to identify the markers differentiating RAP from CP.RESULTS: One hundred and thirteen consecutive patients(RAP=32, CP=81) and 78 healthy controls were prospectively enrolled. The mean(SD) age of the patients was 32.0(14.0)years; 89(78.8%) were male. All markers were significantly higher in CP patients than in the controls(P<0.001); MCP-1NGF and HA were significantly higher in RAP patients than in the controls(P<0.001). Stepwise discriminant analysis showed significant difference(P=0.002) between RAP and CP for resistin with an accuracy of 61.9%, discriminant scores of ≤-0.479 and ≥0.189 indicating RAP and CP, respectively. The other markers had no differential value between RAP and CP.CONCLUSION: Serum resistin is a promising marker to differentiate between RAP and CP and needs validation in future studies, especially in those with early CP. | M Ganesh Kamath C Ganesh Pai Asha Kamath Annamma Kurien | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 7 |
| 2 | Characterization and phylogenetic analysis of novel polyene type antimicrobial metabolite producing actinomycetes from marine sediments:Bay of Bengal India显示文摘Objective:To isolate and indentify the promising antimicrobial metabolite producing Streptomyces strains from marine sediment samples from Andraprudesh coast of India.Methods:Antagonistic aetinomycetes were isolated by starch casein agar medium and modified nutrient agar medium with 1%glucose used as a base for primary screening.Significant antimicrobial metabolite producing strains were selected and identified by using biochemical and 16S rDNA level.Minimum inhibitory concentrations of the organic extracts were done by using broth micro dilution method.Results:Among the 210 actinomyeetes,64.3%exhibited activity against Gram positive bacteria,48.5%showed activity towards Cram negative bacteria,38.8%exhibited both Cram positive and negative bacteria and 80.85%isolates revealed significant antifungal activity.However,five isolates AP-5,AP-18,AP-41 and AP-70 showed significant antimicrobial activity.The analysis of cell wall hydrolysates showed the presence of LL-diaminopimelic acid and glycine in all the isolates.Sequencing analysis indicated that the isolates shared 98.5%-99.8%sequence identity to the 16S rDNA gene sequences of the Streptomyces taxons.The antimicrobial substances were extracted using hexane and ethyl acetate from spent medium in which strains were cultivated at 30X for five days.The antimicrobial activity was assessed using broth micro dilution technique.Each of the culture extracts from these five strains showed a typical polyenelike property.The lowest minimum inhibitory concentrations of ethyl acetate extracts against Escherichia coli and Cumularia lunula were 67.5 and 125.0μg/mL,respectively.Conclusions:It can be concluded that hexane and ethyl acetate soluble extracellular products of novel isolates are effective against pathogenic bacteria and fungi. | Valan Arasu M Asha KRT Duraipandiyan V Ignacimuthu S Agastian P | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 3 | Synthesis and curing studies of PPG based telechelic urethane methacryllc macromonomers显示文摘 | Asha S K Thirumal M Kavitha A | 2005 | European Polymer Journal2005，41，1： | 1 |
| 4 | In vitro anti- Heli- cobacter pylofi activity of a flavonoid rich extract of C, tycyrrhiza glabra and its probable mechanisms of action显示文摘 | Asha M K Debraj D Prashanth D | 2013 | J Ethnophar- ma2013，145，2： | 1 |
| 5 | Synthesis and curing studies of PPG based teleehelie urethane methaerylic 显示文摘 | Asha S K Thirumal M Kavitha A | 2005 | European Polymer Journal2005，41，1： | 1 |
| 6 | Spectroscopic studies on the interaction of colloidal capped CdS nanoparticles with bovine serum albumin 显示文摘 | Asha Jhonsi M Kathiravan A Renganathan R | 2009 | Colloids and Surface B : Biointerfaces2009，72，： | 1 |
| 7 | Cytotoxicity and genotoxicity of silver nanoparticles in human cells显示文摘 | Asha Rani P V Low K M G Valiyaveettil S | 2009 | ACS Nano2009，3，2： | 1 |
| 8 | Induction therapy in pediatric renal transplant recipients 显示文摘 | Asha M Dechu P | 2007 | Pediatric Drugs2007，9，5： | 1 |
| 9 | Interaction of carbon dioxide with oxidized La/Cu(111)显示文摘 | De Asha A M Nix R M | 1995 | J Chem Soc: Farad Trans1995，91，20： | 1 |
| 10 | A new method in selective assembly to minimize clearance variation for a radial assembly using genetic algorithm 显示文摘 | Kannan S M Asha A Jayabalan V | 2005 | Quality Engineering2005，17，4： | 1 |
| 11 | On nearly-compact spaces显示文摘 | Smgal M K Asha Mathur | 1969 | Boll Un Mat Ital1969，4，2： | 1 |
| 12 | Psychological care in trauma patient显示文摘 | Mohta M Sethi AK Asha Tyagi | 2003 | Int J Care Injured2003，34，： | 1 |
| 13 | Effect of rheological properties of batter and addition of thermally modified rice on quality of vada-a blackgram based fried product显示文摘 | Asha M R Susheelamma N S Bhat K K | 2009 | Journal of Food Science and Technology2009，46，3： | 1 |
| 14 | TRAF6-dependent NF-KB transcriptional activity during mouse development显示文摘 | Kathleen M D Asha L B Barker P A | 2004 | Dev Dyn2004，231，1： | 1 |
| 15 | Rheological properties of black gram (Phaseolus mungo) batter: characterisation of flour from native and modified rice and their effect on batter viscosity显示文摘 | Asha M R Susheelamma N S Guha M | 2007 | International Journal of Food Science and Tech- nology2007，42，6： | 1 |
| 16 | NF-κB is constitutively activated in high-grade squamous intmep ithelial lesions and squamous cell carcinomas of the human uterine cervix显示文摘 | Asha N Manickam V Tessy T M | 2003 | Oncogene2003，22，1： | 1 |
| 17 | Synthesis and curing studies of PPG based telechelic urethane methacrylic macromonomers 显示文摘 | ASHA S K THIRUMAL M KAVITHA A PILLAIC K S | 2005 | European Polymer Journal2005，41，1： | 1 |
| 18 | Sensitive immunoassays for methyl-parathion and parathion and their application to residues in foodetuffs显示文摘 | Skerrit J H Guihot S L Asha M H | 2003 | Food and Agricultural Immunology2003，15，1： | 1 |
| 19 | Antigen expression in biofilm cells of Aeromonas hydrophila employed in oral vaccination of fish显示文摘 | Asha A Nayaka D K Shankar K M | 2004 | Fish Shellfish Immunol2004，16，： | 1 |
| 20 | NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis显示文摘 | Amir H Salehi Philippe P Roux Chris J Kubu Christine Zeindler Asha Bhakar Laura-Lee Tannis Joseph M Verdi Philip A Barker | 2000 | Neuron2000，，2： | 1 |
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