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1篇 您的检索式：作者名="Ashujit Tagde"

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		题名	作者	年代	出处	被引量
	1	Targeting MUC1-C suppresses BCL2A1 in triple-negativebreast cancer显示文摘B-cell lymphoma 2-related protein A1(BCL2A1)is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs;however,there are presently no agents that target BCL2A1.The MUC1-C oncoprotein is aberrantly expressed in triple-negative breast cancer(TNBC)cells,induces the epithelial–mesenchymal transition(EMT)and promotes anti-cancer drug resistance.The present study demonstrates that targeting MUC1-C genetically and pharmacologically in TNBC cells results in the downregulation of BCL2A1 expression.The results show that MUC1-C activates the BCL2A1 gene by an NF-κB p65-mediated mechanism,linking this pathway with the induction of EMT.The MCL-1 anti-apoptotic protein is also of importance for the survival of TNBC cells and is an attractive target for drug development.We found that inhibiting MCL-1 with the highly specific MS1 peptide results in the activation of the MUC1-C→NF-κB→BCL2A1 pathway.In addition,selection of TNBC cells for resistance to ABT-737,which inhibits BCL-2,BCL-xL and BCL-W but not MCL-1 or BCL2A1,is associated with the upregulation of MUC1-C and BCL2A1 expression.Targeting MUC1-C in ABT-737-resistant TNBC cells suppresses BCL2A1 and induces death,which is of potential therapeutic importance.These findings indicate that MUC1-C is a target for the treatment of TNBCs unresponsive to agents that inhibit anti-apoptotic members of the BCL-2 family.	Masayuki Hiraki Takahiro Maeda Neha Mehrotra Caining Jin Maroof Alam Audrey Bouillez Tsuyoshi Hata Ashujit Tagde Amy Keating Surender Kharbanda Harpal Singh Donald Kufe	2018	Signal Transduction and Targeted Therapy2018，3，1：	1

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