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| 1 | Recent advances in the diagnosis and treatment of acute myocardial infarction显示文摘The Third Universal Definition of Myocardial Infarction(MI) requires cardiac myocyte necrosis with an increase and/or a decrease in a patient's plasma of cardiac troponin(cT n) with at least one cT n measurement greater than the 99 th percentile of the upper normal reference limit during:(1) symptoms of myocardialischemia;(2) new significant electrocardiogram(ECG) ST-segment/T-wave changes or left bundle branch block;(3) the development of pathological ECG Q waves;(4) new loss of viable myocardium or regional wall motion abnormality identified by an imaging procedure; or(5) identification of intracoronary thrombus by angiography or autopsy.Myocardial infarction,when diagnosed,is now classified into five types.Detection of a rise and a fall of troponin are essential to the diagnosis of acute MI.However,high sensitivity troponin assays can increase the sensitivity but decrease the specificity of MI diagnosis.The ECG remains a cornerstone in the diagnosis of MI and should be frequently repeated,especially if the initial ECG is not diagnostic of MI.There have been significant advances in adjunctive pharmacotherapy,procedural techniques and stent technology in the treatment of patients with MIs.The routine use of antiplatelet agents such as clopidogrel,prasugrel or ticagrelor,in addition to aspirin,reduces patient morbidity and mortality.Percutaneous coronary intervention(PCI) in a timely manner is the primary treatment of patients with acute ST segment elevation MI.Drug eluting coronary stents are safe and beneficial with primary coronary intervention.Treatment with direct thrombin inhibitors during PCI is non-inferior to unfractionated heparin and glycoprotein Ⅱb/Ⅲa receptor antagonists and is associated with a significant reduction in bleeding.The intra-coronary use of a glycoprotein Ⅱb/Ⅲa antagonist can reduce infarct size.Pre- and post-conditioning techniques can provide additional cardioprotection.However,the incidence and mortality due to MI continues to be high despite all these recent advances.The initial ten year experience with autologous human bone marrow mononuclear cells(BMCs) in patients with MI showed modest but significant increases in left ventricular(LV) ejection fraction,decreases in LV endsystolic volume and reductions in MI size.These studies established that the intramyocardial or intracoronary administration of stem cells is safe.However,many of these studies consisted of small numbers of patients who were not randomized to BMCs or placebo.The recent LateT ime,Time,and Swiss Multicenter Trials in patientswith MI did not demonstrate significant improvement in patient LV ejection fraction with BMCs in comparison with placebo.Possible explanations include the early use of PCI in these patients,heterogeneous BMC populations which died prematurely from patients with chronic ischemic disease,red blood cell contamination which decreases BMC renewal,and heparin which decreases BMC migration.In contrast,cardiac stem cells from the right atrial appendage and ventricular septum and apex in the SCIPIO and CADUCEUS Trials appear to reduce patient MI size and increase viable myocardium.Additional clinical studies with cardiac stem cells are in progress. | Koushik Reddy Asma Khaliq Robert J Henning | 2015 | World Journal of Cardiology2015，7，5： | 107 |
| 2 | Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect显示文摘AIM: To assess numbers and case fatality of patients with upper gastrointestinal bleeding(UGIB),effects of deprivation and whether weekend presentation affected outcomes.METHODS: Data was obtained from Information Services Division(ISD) Scotland and National Records of Scotland(NRS) death records for a ten year period between 2000-2001 and 2009-2010. We obtained data from the ISD Scottish Morbidity Records(SMR01) database which holds data on inpatient and daycase hospital discharges from non-obstetric and nonpsychiatric hospitals in Scotland. The mortality data was obtained from NRS and linked with the ISD SMR01 database to obtain 30-d case fatality. We used 23 ICD-10(International Classification of diseases) codes which identify UGIB to interrogate database. We analysed these data for trends in number of hospital admissions with UGIB,30-d mortality over time and assessed effects of social deprivation. We compared weekend and weekday admissions for differences in 30-d mortality and length of hospital stay. We determined comorbidities for each admission to establish if comorbidities contributed to patient outcome. RESULTS: A total of 60643 Scottish residents were admitted with UGIH during January,2000 and October,2009. There was no significant change in annual number of admissions over time,but there was a statistically significant reduction in 30-d case fatality from 10.3% to 8.8%(P < 0.001) over these 10 years. Number of admissions with UGIB was higher for the patients from most deprived category(P < 0.05),although case fatality was higher for the patients from the least deprived category(P < 0.05). There was no statistically significant change in this trend between 2000/01-2009/10. Patients admitted with UGIB at weekends had higher 30-d case fatality compared with those admitted on weekdays(P < 0.001). Thirty day mortality remained significantly higher for patients admitted with UGIB at weekends after adjusting for comorbidities. Length of hospital stay was also higher overall for patients admitted at the weekend when compared to weekdays,although only reached statistical significance for the last year of study 2009/10(P < 0.0005). CONCLUSION: Despite reduction in mortality for UGIB in Scotland during 2000-2010,weekend admissions show a consistently higher mortality and greater lengths of stay compared with weekdays. | Asma Ahmed Matthew Armstrong Ishbel Robertson Allan John Morris Oliver Blatchford Adrian J Stanley | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 3 | Post splenectomy related pulmonary hypertension显示文摘Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management. | Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar | 2015 | World Journal of Respirology2015，5，2： | 3 |
| 4 | Spatiotemporal reconstruction of list-mode PET data显示文摘 | Nichols TE Oi J Asma E | 2002 | IEEE Transactions on Medical Imaging2002，21，4： | 1 |
| 5 | First trimester maternal serum placental protein 13 for the prediction of pre - eclampsia in women with a priori high risk 显示文摘 | Asma Khalill Nicholas J Cowans | 2009 | Prenat Diagn2009，29，： | 1 |
| 6 | Spatiotemporal reconstruction of list-mode PET data 显示文摘 | Nichols T E Qi J Asma E | 2002 | IEEE Transactions on Medical Imaging2002，21，4： | 1 |
| 7 | Spatiotemporal reconstruction of list-mode PET data显示文摘 | Nichols TE Qi J Asma E | 2002 | IEEE Transaction on Medical Imaging2002，21，4： | 1 |
| 8 | Junction Adhesion Molecule Is a Receptor for Reovirus显示文摘 | Erik S Barton J.Craig Forrest Jodi L Connolly James D Chappell Yuan Liu Frederick J Schnell Asma Nusrat Charles A Parkos Terence S Dermody | 2001 | Cell2001，，： | 1 |
| 9 | Ventilator-associated pneumonia in a neurologic intensive care unit does not lead to increased mortality显示文摘 | Andrew J Asma M Michael A | 2010 | Neurocrit Care2010，12，： | 1 |
| 10 | Identification of a novel mu- tation in the MCFD2 gene in a Tunisian family with combined fac- tor V and V defieiency显示文摘 | Hejer E Adnen L M Asma J | 2012 | Tunis Med2012，90，4： | 1 |
| 11 | Soil Distribution of Fipronil and Its Metabolites Originating from a Seed-coated Formulation显示文摘 | MURIEL R ASMAE A WILLISON J | 2007 | Chemosphere2007，69，7： | 1 |
| 12 | Pulse wave velocity as end- point in large- scale intervention trial 显示文摘 | Asma R Topouchian J Pannier B | 2001 | Hypertens2001，19，4： | 1 |
| 13 | Detection of sensorineural hearing loss using auto- mated auditory brainstem-evoked response and transient-evoked otoacoustic emission in term neonates with severe hyperbiliru- binaemia显示文摘 | Boo N Y Rohani A J Asma A | 2008 | Singapore Med J2008，49，3： | 1 |
| 14 | Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosino- phil recall response: potential adjuvant for helminth vaccines? 显示文摘 | BURKE J M GANLEY-LEAL L M ASMA KHATRI | 2007 | J Immunol2007，179，： | 1 |
| 15 | Tribosurfacecharacteristics of Al-B4C and Al-SiC composites worn under different contact pressures显示文摘 | Shorowordi K M Haseeb ASMA Celis J P | 2006 | Wear2006，261，： | 1 |
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