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| 1 | Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats显示文摘OBJECTIVE: Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out different tests to evaluate the effect of aqueous extract of Solanum xanthocarpum(SXE) in postmenopausal syndrome. METHODS: The study was carried out in bilaterally ovariectomized one-month-old Wistar rats(40–50 g). Bilaterally ovariectomized(OVX) Wistar rats were divided into four groups(n=6) receiving different treatments, consisting of a vehicle(distilled water), aqueous extract of Solanum xanthocarpum at two different doses(200 and 400 mg/kg) administered orally daily for 90 d and standard drug β estradiol at a dose of 1 mg/kg administered subcutaneously biweekly for 90 d. Estrogenic activity was assessed by vaginal cornifi cation, sexual behavior, serum estradiol and uterine weight to body weight ratio. Antiosteoporotic activity was assessed on the basis of biomechanical and biochemical parameters followed by histopathological studies, and antidepressant activity was assessed by forced swim test. RESULTS: SXE showed presence of steroids. At the dose of 200 mg/kg, it signifi cantly improved all the parameters of sexual behavior(P<0.01), caused vaginal cornifi cation, and increased serum estradiol and uterine weight(P<0.01). It also significantly improved all the parameters of bone strength as well as depression(P<0.01). Histopathology of bones confi rmed the above fi ndings. CONCLUSION: The study indicated that SXE may provide an effective treatment in the prevention of postmenopausal symptoms. | Urmila Aswar Mayuri Gurav Ganesh More Khaled Rashed Manoj Aswar | 2014 | Journal of Integrative Medicine2014，12，5： | 3 |
| 2 | Antidepressant effects of standardized extract of Centella asiatica L in olfactory bulbectomy model显示文摘 | Padmaja Kalshetty Urmila Aswar Subhash Bodhankar Arulmozhi Sinnathambi V. Mohan Prasad Thakurdesai | 2012 | Biomedicine & Aging Pathology2012，，2： | 1 |
| 3 | Synthesis, Thermal, Electrical and Catalytic Studies of Some Transition Metal Polychelates of Bis-bidentate Schiff Base显示文摘Mn ( II )的 Polychelates , Fe ( II ),公司( II ), Ni ( II ), Cu ( II ), Zn ( II )和有二度salen类型 ligand 的 Cd ( II )源于4,4二度[( salicylaldehyde-5 )偶氮]联本基和 1,4-diaminobutane 被综合了。所有 polychelates 被元素的分析,磁性的危险性大小,红外,电子系列和 thermogravimetric 研究描绘了。处于稳固的状态孤立的所有建筑群是在水里有色、不可溶解、普通的黑暗器官的溶剂。ligand 作为通过酉分的氧和 azomethine 氮原子协调的一个二度有二齿的分子表现。这些金属建筑群的热分解被 thermogravimetric 分析调查,数据用 Broido 方程为运动参数被分析了。固态在压缩小团形式的 ligand 和它的 polychelates 的电的电导率从 313 ~ 413 K 在温度范围被学习。所有 polychelates 被发现显示出半导体的自然。Mn (II ) , Fe (II ) ,公司(II ) 和 Ni (II ) polychelates 为苯乙烯的催化 epoxidation 被估计了。 | BANSOD, Ashish ASWAR, Anand | 2007 | Chinese Journal of Chemistry2007，25，2： | 1 |
| 4 | Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats显示文摘 | A. Rahigude P. Bhutada S. Kaulaskar M. Aswar K. Otari | 2012 | Neuroscience2012，，： | 1 |
| 5 | Study of Furostenol Glycoside Fraction of Tribulus terresteris . on Male Sexual Function in Rats显示文摘 | Ravindar Mohan Tyagi Urmila M. Aswar V. Mohan S. L. Bodhankar G. N. Zambare Prasad A. Thakurdesai | 2008 | Pharmaceutical Biology2008，，3： | 1 |
| 6 | Amelioration ofcardiac hypertrophy induced by abdominal aortic banding in ferulicacid treated rats显示文摘 | ASWAR U MAHAJAN U NERURKAR G | 2013 | Biomed Aging Pathol2013，3，4： | 1 |
| 7 | Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats显示文摘Objective:To study the derivatives of 1,2,4-triazino[5,6-b]indole-3-thione for antidepressant activity in olfactory bulbectomized(OBX)rats.Out of various derivatives tested for acute tail suspension test,the two derivatives showiug prominent action were.selected for bilateral olfactory bulbeetomy rsodel of ehronic depression in rats.Methods:The sub aeute effects of 14-day oral pretreatment of two derivatives labeled as 3a(70 mg/kg)and 3r(70 mg/kg),imipramine(20 mg/kg),fluoxetiue(30 mg/kg)and moclobemide(15 mg/kg)were evaluated on bilateral bulbectomy induced rise in body weight,hyperphagia,hyperactivity,and on sexual dysfunction.The serum sodium concentration,body temperature,and heart rate were also recorded.Results:The derivatives3a and 3r showed reversal of drop in body weight,reversed OBX indueed hyperactivity,normalized body temperature,heart rate,and serum sodium concentration.In elevated maze test,moclobemide,3a,3r treatment significantly redueed time spent in open arm as compared to OBX rats.3a and 3r also irsproved sexual behavior parameters.Conclusions:The present study shows promising antidepressant action and provides a proof of concept for the chronic treatrsent of 3a,3r to treat depression. | Urmila M Aswar Padmaja P Kalshetti Suhas M Shelke Sharad H Bhosale Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 1 |
| 8 | Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica(L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors显示文摘The present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside(AS) based standardized extract of Centella asiatica(L.) Urban leaves(INDCA) in animal models of migraine. The effects of oral and intranasal(i.n.) pretreatment of INDCA(acute and 7-days subacute) were evaluated against nitroglycerine(NTG, 10 mg·kg-1, i.p.) and bradykinin(BK, 10 μg, intra-arterial) induced hyperalgesia in rats. Tail flick latencies(from 0 to 240 min) post-NTG treatment and the number of vocalizations post-BK treatment were recorded as a measure of hyperalgesia. Separate groups of rats for negative(Normal) and positive(sumatriptan, 42 mg·kg-1, s.c.) controls were included. The interaction of INDCA with selective 5-HT1 A, 5-HT1 B, and 5-HT1 D receptor antagonists(NAN-190, Isamoltane hemifumarate, and BRL-15572 respectively) against NTG-induced hyperalgesia was also evaluated. Acute and sub-acute pre-treatment of INDCA [10 and 30 mg·kg-1(oral) and 100 μg/rat(i.n.) showed significant anti-nociception activity, and reversal of the NTG-induced hyperalgesia and brain 5-HT concentration decline. Oral pre-treatment with INDCA(30 mg·kg-1, 7 d) showed significant reduction in the number of vocalization. The anti-nociceptive effects of INDCA were blocked by 5-HT1 A and 5-HT1 B but not 5-HT1 D receptor antagonists. In conclusion, INDCA demonstrated promising anti-nociceptive effects in animal models of migraine, probably through 5-HT1A/1B medicated action. | Vijeta Bobade Subhash L.Bodhankar Urmila Aswar Vishwaraman Mohan Prasad Thakurdesai | 2015 | Chinese Journal of Natural Medicines2015，13，4： | 0 |
| 9 | Phytochemical analysis and antifertility potential of Cynodon dactylon in female Wistar rats:A herbal approach towards contraception显示文摘Objective:The objective of the present study was to evaluate the antifertility activity of ether(ErCD),chloroform(CeCD)and ethyl alcohol(EyCD)extracts of the whole plant of Cynodon dactylon in female Wistar albino rats.Methods:Acute oral toxicity and an antifertility study were performed in female Wistar rats with two dose levels(200 and 400 mg/kg,orally)of EyCD.The estrogenic and progestogenic effects of EyCD were further observed by administering it to immature Wistar rats by investigations of vaginal cornification,hormonal level,uterus weight,biochemical parameters,histopathology of the uterus and deciduoma formation,respectively.Isolation of EyCD was carried out by Flash Chromatography and isolated fraction was estimated by HPLC.Results:No toxicity with any of the extract was found up to the dose of 2000 mg/kg body weight.EyCD treated rats exhibited maximum reduction in pregnancy(83.33%).Estimation of EyCD on vaginal cornification,estrogen-induced uterotrophic assay and deciduoma model demonstrated vaginal cornification,significant(P<0.01)increase in uterine weight and uterine proliferation in histopathology and reduced deciduoma formation respectively.Hormonal and biochemical parameters confirmed the above findings indicating estrogenic potential and antiprogestogenic potential of EyCD that might be attributed to the presence of phytoestrogen(apigenin)in EyCD.Conclusion:The results suggested that extracts of C.dactylon possess significant antifertility activity,which is consistent with the literature reported in folk medicine of this plant in fertility regulation. | Arati Malpani Nitin Mahurkar Urmila Aswar | 2020 | Chinese Herbal Medicines2020，12，3： | 0 |
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