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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Analytical solutions of the diffraction problem of a group of truncated vertical cylinder显示文摘 | Oguz Yilmaz Atilla Incecik | 1998 | Ocean Engineering1998，25，6： | 1 |
| 3 | Analytical solutions of the diffraction problem of a group of mmcated vertical cylinder显示文摘 | Ognz Yilmaz Atilla Incecik | 1998 | Ocean Engineering1998，25，6： | 1 |
| 4 | Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension显示文摘 | Christian Stumpf Stefan John Jelena Jukic Atilla Yilmaz Dorette Raaz Roland E Schmieder Werner G Daniel Christoph D Garlichs | 2005 | Journal of Hypertension2005，，： | 1 |
| 5 | Hypogonadism is not related to the etiology of liver cirrhosis显示文摘 | Sabahattin Kaymako?lu Atilla ?kten Yilmaz ?akalo?lu Güng?r Bozta? Fatih Be?i?ik Cemil Ta??io?lu Süleyman Yal?in | 1995 | Journal of Gastroenterology1995，，6： | 1 |
| 6 | Hypogonadism is not related to the etiology of liver cirrhosis显示文摘 | Sabahattin Kaymako?lu Atilla ?kten Yilmaz ?akalo?lu Güng?r Bozta? Fatih Be?i?ik Cemil Ta??io?lu Süleyman Yal?in | 1995 | Journal of Gastroenterology1995，，6： | 1 |
| 7 | Intrahepatic and peripheral T-cell responses in genotype 1b hepatitis C virus-infected patients with persistently normal and elevated aminotransferase levels显示文摘AIM: To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels. METHODS: Thirty-three (16 with normal ALT level as group 1 and 17 with elevated ALT level as group 2) patients infected with genotype 1b hepatitis C virus (HCV) were examined. Liver infiltrating lymphomononuclear cells (LILMCs) were isolated from liver biopsy by collagenase type 1 and stimulated with phytohemagglutinin and interleukin 2 (IL-2). IL-10, IL-12, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were determined in serum and LILMCs by ELISA. RESULTS: Serum cytokine levels were similar in both groups (P>0.05). Stimulated IFN-γ and TNF-α levels in LILMCs were increased in both groups. IL-12 and IL-10 levels stimulated with IL-2 were higher in group 1 than in group 2 (P = 0.023). Histological activity index (HAI) and stage had a negative correlation with TNF-α and IFN-γ levels in group 2. CONCLUSION: Increased T-helper type 2 (Th2) cytokine response may regress inflammatory and biochemical activity. Progression of histological abnormalities in persons with elevated ALT probably depends on insufficient Th2 cytokine response, which does not balance Th1 cytokine response. | Filiz Akyüz Nuray Polat Sabahattin Kaymakoglu Nevzat Aksoy Kadir Demir Fatih Besisik Selim Badur Yilmaz Cakaloglu Atilla (O|¨)kten | 2005 | World Journal of Gastroenterology2005，11，45： | 1 |
| 8 | Synthesis and liquidcrystalline behaviour of Ni( II ) and Zn( II ) phthalocyanines with peripheral monoazacrown ethers 显示文摘 | Fatma Yilmaz Devrim Atilla | 2004 | Polyhedron2004，23，： | 1 |
| 9 | Can venous blood gas analysis be used for predicting seizure recurrence in emergency department?显示文摘BACKGROUND:Epileptic seizures account for 1%–2% of all admissions of patients to the emergency department(ED). The present study aimed to determine whether venous blood pH,bicarbonate,base excess,and lactate levels taken within 1 hour of the last seizure episode help to determine seizure recurrence in emergency departments.METHODS:A cross-sectional study was conducted in the emergency department(ED) between January and July,2012. Patients who were admitted to the emergency department consecutively were included in the study if they were 14 years or older and within 1 hour after last seizure. Demographics,seizure type,use of antiepileptic drugs,observation period at the emergency department,seizure recurrence,pH,bicarbonate,base excess,and lactate levels from venous blood gas analysis were determined.RESULTS:A total of 94 patients aged 14 years or older were included in the study. Of these patients,10.6%(n=10) experienced recurrent seizures in the observation period at the emergency department. To predict recurrent seizures in ED,threshold venous blood gas values were determined as follows:pH<7.245 [sensitivity 80%(95%CI:44–96),negative predictive value 96.9%(95%CI:88.3–99.4)],bicarbonate<17.1 mmol/L [sensitivity 80%(95%CI:44–96),negative predictive value 97%(95%CI:89–99.5)],base excess<–11.1 mEq/L [sensitivity 80%(95%CI:44–96),negative predictive value 97%(95%CI:89–99)],and lactate>7.65 mmol/L [sensitivity 80%(95%CI:44–96),negative predictive value 96.6%(95%CI:87–99)].CONCLUSION:If venous blood gas analysis is made on pH,base excess,lactate and bicarbonate immediately one hour after the last epileptic seizure episode,it is possible to predict whether the patient will have seizure recurrence. | Turgay YIlmaz KIlIc Murat Yesilaras Ozge Duman Atilla Mustafa Sever Ersin Aksay | 2014 | World Journal of Emergency Medicine2014，5，3： | 0 |
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