|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function显示文摘Background and aim:The liver is the primary organ affected by cholestasis,and complications such as renal injury,renal failure,and the need for renal transplantation are associated with cholestatic liver disease.There is substantial evidence indicating that reactive oxygen species(ROS)and mitochondrial impairment are fundamental mechanisms underlying cholestasis-induced hepatic and renal injury.Edaravone(EDV)is a potent radical scavenger and antioxidant that may prevent oxidative stress and improve impaired mitochondrial function in various diseases.This study was performed to evaluate the effects and mechanisms of action of EDV on hepatic and renal injury in an animal model of cholestasis.Methods:Rats subjected to bile duct ligation(BDL)were treated with EDV 1 or 10 mg/kg/day intraper-itoneally for 14 consecutive days.Biomarkers of oxidative stress and mitochondrial impairment in the liver and kidney were assessed in EDV-treated and untreated rats with cholestasis.Results:Significant increases in tissue ROS level,lipid peroxidation,protein carbonylation,and oxidized glutathione level were detected in rats subjected to BDL.Additionally,significant decreases in tissue glutathione level and antioxidant capacity were observed in the hepatic and renal tissues of rats with cholestasis.Markers of mitochondrial impairment,including mitochondrial depolarization,lipid perox-idation,mitochondrial permeabilization,depleted adenosine triphosphate content,and decreased de-hydrogenase activity,were also detected in rats subjected to BDL.Furthermore,portal inflammation,necrosis,and tissue fibrosis were detected in the liver and significant tubular atrophy and interstitial inflammation,as well as fibrotic lesions,were detected in the kidneys of rats with cholestasis.EDV treatment significantly mitigated cholestasis-associated hepatic and renal injury.Conclusions:The antioxidative properties of EDV and its positive effects on the indices of mitochondrial function may be critical factors contributing to protection against cholestasis-associated hepatic and renal injury. | Mohammad Mehdi Ommati Hanie Attari Asma Siavashpour Marzieh Shafaghat Negar Azarpira Hasti Ghaffari Leila Moezi Reza Heidari | 2021 | Liver Research2021，5，3： | 2 |
| 2 | Autoimmune pancreatitis mimicking carcinoma of the head of the pancreas: a case report显示文摘 | Ghadir MR Sheikhesmaili F Attari F | 2012 | J Med Case Reports2012，116，1： | 1 |
| 3 | Erosion - corrosion behavior of some cast alloys in seawater显示文摘 | Shalaby H M Attari S Ruad W T | 1992 | Corrosion1992，48，3： | 1 |
| 4 | Effects of narrow slits on frequen- cy response of a microstrip square loop resonator and dual -mode filter applications 显示文摘 | Rezaee M Attari A R | 2013 | Microwave and Optical Technology Letters2013，55，1： | 1 |
| 5 | Wave in a patient with an acute inferior myocardial infarction显示文摘 | Madias JE Attari M Demetrius B | 2001 | J Electrocardiol2001，34，： | 1 |
| 6 | Antimicrobial activities of Iranian sumac and avishane shirazi(Zatariamuhifora) against some food- borne bacteria 显示文摘 | Fazeli MR Amin G Attari MMA | 2007 | Food Control2007，18，： | 1 |
| 7 | Corrosion control of mild steel using 3,5-bis(4-methoxyphenyl)-4-amino-l,2,4-triazole in normal hydrochloric acid medium 显示文摘 | BENTISS F JAMA C MERNARI B El ATTARI H E1 KADI L LEBRINI M TRAISNEL M LAGRENEE M | 2009 | Corrosion Science2009，51，： | 1 |
| 8 | Inhibition of glycogen synthase kinase- 3 promotes efficient derivation of pluripotent stern ceils from neonatal mouse testis 显示文摘 | Moraveji SF Attari F Shahverdi A | 2012 | Hum Reprod2012，27，： | 1 |
| 9 | Spinal anesthe-sia versus general anesthesia for elective lumbar spine surgery : Arandomized clinical trial显示文摘 | Attari MA Mirhosseini SA Honarmand A | 2011 | J Res Med Sci2011，16，4： | 1 |
| 10 | Comparative evaluation of the effects of tranexamic acid and low - dose aprotinin on post - val-vular heart surgery bleeding and allogenic transfusion显示文摘 | MANSOURI M ATTARY M BAGHERI K | 2012 | Interact Cardiovasc Thorac Surg2012，15，1： | 1 |
| 11 | Efficient induc-tion of pluripotency in primordial germ cells by dual inhibition of TGF 13 and ERK signaling pathways显示文摘 | ATTARI F SEPEHRI H ANSARI H | 2014 | Stem Cells and De velopment2014，23，10： | 1 |
| 12 | Review of water pricing theories and related models显示文摘 | Mohayidin G AttarI J SadeghI A | 2009 | African Journal of Agricultural Research2009，4，13： | 1 |
| 13 | Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis显示文摘 | Moraveji SF Attari F Shahverdi A | | 0，，08： | 1 |
| 14 | Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells显示文摘 | Attari F Sepehri H Delphi L | 2009 | Iran Biomed J2009，13，4： | 1 |
| 15 | Giant R-waves in a patient with an acute inferior myocardial infarction显示文摘 | Madias JE Attari M Bravidis D | | 0，，： | 1 |
| 16 | Giant R-waves in a patient with an acute inferior myocardial infarction显示文摘 | Madias JE Attari M Bravidis D | 2001 | J Electrocardiol2001，34，2： | 1 |
| 17 | Improved Photonic Crystal Directional Coupler With Short Length 显示文摘 | Moghaddam M K Attari A R Mirsalehi M M | 2010 | Photonies and Nanostructures-Fundamentals and Applications2010，8，1： | 1 |
| 18 | Ulcerative colitis and irritable bowel syndrome: relationships with quality of life 显示文摘 | Ansari R Attari F Razjouyan H | 2008 | Eur J Gastroenterol Hepatol2008，20，1： | 1 |
| 19 | Giant R-waves in a patient with an acute inferior myocardial infarction 显示文摘 | Madias JE Attari M Bravidis D | 2001 | J Electrocardiol2001，34，2： | 1 |
| 20 | Restoration of primary teeth with crowns: A systematic review of the literature显示文摘 | Attari N Roberts JF | 2006 | Eur Arch Paediatr Dent2006，7，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员