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| 1 | Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report显示文摘BACKGROUND Cardiac tumors are rare and complex entities.Surgery represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very poor.Lack of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac sarcomas.Herein,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly woman.CASE SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart failure.Imaging examination revealed a large,left atrial mass.With suspicion of a myxoma,she underwent surgery,and symptoms were promptly relieved.Histology showed a cardiac myxofibrosarcoma,a rare histotype of cardiac sarcoma.Eight months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still present.This report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at relapse.Moreover,due to their rarity,very little is known about the molecular landscape of myxofibrosarcomas.Thus,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable targets.CONCLUSION We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy. | Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 2 | In situ evaluation of different remineralization periods to decrease brushing abrasion of demineralized enamel显示文摘 | ATTIN T KNOFEL S BUCHALA W | 2001 | Caries Res2001，35，3： | 1 |
| 3 | Review on fluoride-releasing restorative materials--fluoride release and uptake characteristics, antibacterial activity and influence on caries formation显示文摘 | Wiegand A Buchalla W Attin T | 2007 | Dent Mater2007，23，3： | 1 |
| 4 | Ex vivo comparison of two electronic apex locators with different scales and frequencies显示文摘 | Hor D Krusy S Attin T | | 0，，12： | 1 |
| 5 | The effect of water storage and light exposure on the color and translucency of a hybrid and a microfilled composite显示文摘 | Buchalla W Attin T Hilgers RD | 2002 | J Prosthet Dent2002，87，3： | 1 |
| 6 | Review on fluoride-releasing restorative materials--fluoride release and uptake characteristics, antibacterial activity and influence on caries formation显示文摘 | Wiegand A Buchalla W Attin T | 2007 | Dent Mater2007，23，3： | 1 |
| 7 | Influence of the canal contents on the electrical assisted determination of the length of root canals显示文摘 | Pommer O Stamm O Attin T | 2002 | J Endod2002，28，2： | 1 |
| 8 | Effect of fluoride treatment on remineralization of bleached enamel显示文摘 | Attin T Kielbassa AM Schwanenberg M | 1997 | J Oral Rehabil1997，24，4： | 1 |
| 9 | Effect of different fluoridation regimes on the microhardness of bleached enamel显示文摘 | Wiegand A Schreier M Attin T | 2007 | Oper Dent2007，32，6： | 1 |
| 10 | The accuracy of electronic working length determination 显示文摘 | Hoer D Attin T | 2004 | Int Endod J2004，37，2： | 1 |
| 11 | In situ evaluation of different remineralization periods to decrease brushing abrasion of demineralized enamel显示文摘 | Knofel S Buchalla W | 2001 | Caries Res2001，35，3： | 1 |
| 12 | Influence of carbamide peroxide on ensmel fluoride uptake显示文摘 | Attin T Albrecht K Becket K | 2006 | J Dent2006，34，9： | 1 |
| 13 | Potential of fluoridated carbamide peroxide gels to support post-bleaching enamel re-hardening显示文摘 | Attin T Betke H Schippan F | 2007 | J Dent2007，35，9： | 1 |
| 14 | Systematic review on the ef- fect of rinsing with povidone-iodine during nonsurgical periodon- tal therapy显示文摘 | Sahrmann P Puhan M A Attin T | 2010 | J Periodontal Res2010，45，2： | 1 |
| 15 | Review of the current status of tooth whitening with the walking bleach technique显示文摘 | Attin T Paque F Ajam F | 2003 | Int Endod J2003，36，5： | 1 |
| 16 | Influence of study design on the impact of bleaching agents on dental enamel microhardness:A review显示文摘 | Attin T Schmidlin PR Wegehaupt F | 2009 | Dent Mater2009，25，2： | 1 |
| 17 | Evaluation of mosaic pattern areas in HRCT with MinIP reconstructions in patients with pulmonary hypertension:could this evaluation replace lung perfusion scintigraphy?显示文摘 | RossiA AttinàD BorgonoviA | 2012 | Eur J Radiol2012，81，1： | 1 |
| 18 | Successful use of a single-re- tainer all-ceramic resin-bonded fixed partial denture for re- placement of a maxillary canine: a clinical report 显示文摘 | Foitzik M Lennon AM Attin T | 2007 | Quintes- sence Int2007，38，3： | 1 |
| 19 | Hel wig Brushing abrasion of eroded dentin after application of sodium fluoride solutions显示文摘 | Attin T Zirkel C Hel wig E | | 0，，05： | 1 |
| 20 | Effect of mineral supplements to citric acid on enamel erosion显示文摘 | Attin T Meyer K Hellwig E | 2003 | Arch Oral Biol2003，48，11： | 1 |
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