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| 1 | Effect of endothelin-1 receptor antagonists on histological and ultrastructural changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats显示文摘AIM: To assess the effect of non-selective ETA/B (LU 302872)and selective ETA (LU 302146) antagonist on pancreatic histology and ultrastructure of acinar cells in connection with trypsinogen activation in early caerulein-induced AP.METHODS: Male Wistar rats with caerulein-induced AP,lasting 4 h, were treated i.p. with 10 and 20 mg/kg b.w.of each antagonist. Edema, inflammatory infiltration,necrosis and vacuolization of acinar cells in the pancreas were scored at 0-3 scale. Free active trypsin (FAT), total potential trypsin (TPT) after activation with enterokinase,and index of trypsinogen activation (%FAT/TPT) were assayed in pancreatic homogenates.RESULTS: In untreated AP, the edema, inflammatory infiltration, necrosis and vacuolization increased as compared to control healthy rats (P<0.01). None of the treatment exerted any meaningful effect on the edema and inflammatory infiltration. The selective antagonist increased slightly the necrosis score to 0.82±0.06 at higher dose (P<0.05) vs 0.58±0.06 in untreated AP. The nonselective antagonist increased slightly the vacuolization score to 2.41±0.07 at higher dose (P<0.01) vs 1.88±0.08in untreated AP. The decrease in the number of zymogen granules, disorganization of endoplasmic reticulum,autophagosomes and cytoplasmic vacuoles were more prominent in treated AP than in untreated AP groups.%FAT/TPT in untreated AP increased about four times (18.4±3.8 vs4.8±1.3 in control group without AP, P<0.001).Treatment of AP with both antagonists did not affect significantly augmented trypsinogen activation.CONCLUSION: The treatment with endothelin-1 receptors (non-selective ETA/B and selective ETA) antagonists has essential effect neither on the edema and inflammatory infiltration nor on trypsinogen activation observed in the early course of caerulein-induced AP. Nevertheless a slight increase of the necrosis and vacuolization score and some of the ultrastructural data could suggest the possibility of their undesired effects in caerulein-induced AP at investigated doses. | Anna Andrzejewska Jan W.Dlugosz Albert Augustynowicz | 2005 | World Journal of Gastroenterology2005，11，8： | 3 |
| 2 | Genotypes of Helicobacter pylori in polish population显示文摘 | GZYL A AUGUSTYNOWICZ E DZIERZANOWSKA D | 1999 | Acta Microbiol Pol1999，48，3： | 1 |
| 3 | Morphometric analysis of the cerebellar cortex capillaries in the course of experimental valproate encephalopathy and after chronic exposure to sodium valproate using transmission electron microscopy显示文摘 | Sobaniec-Lotowska M Sobaniec W Augustynowicz A | 2001 | Folia Neuropathol2001，39，4： | 1 |
| 4 | Cryogenic insulation systemfor soft vacuum显示文摘 | Augustynowicz S Fesmire J | 2000 | Advances in Cryogenic Engineer-ing2000，45，： | 1 |
| 5 | Assessment of proliferative activity of thyroid Hürthle cell tumors using PCNA,Ki-67 and AgNOR methods显示文摘 | Augustynowicz A Dzieciol J Barwijuk-Machala M | 2004 | Folia Histochem Cytobiol2004，42，3： | 1 |
| 6 | Assessment of proliferative activity of thyroid Hurthle cell tumors using PCNA,Ki-67 and AgNOR methods显示文摘 | Augustynowicz A Dzieciol J Barwijuk-Machala M | | 0，，03： | 1 |
| 7 | Development of broad-range polymerase chain reaction (PCR) bacterial identification in diagnosis of infective endocarditis 显示文摘 | Hryniewiecki T Gzyl A Augustynowicz E | 2002 | J Heart Valve Dis2002，11，6： | 1 |
| 8 | Temporal nueleotide changes in pertactin and pertussis toxin genes in Bordetella pertussis strains isolated from clinical eases in Poland显示文摘 | Augustynowicz E Van Loo I | 2001 | Vaccine2001，20，34： | 1 |
| 9 | Amplified fragment length polymorphism (AFLP) versus randomly amplified polymorphic DNA (RAPD) as new tools for inter-and intraspecies differentiation within Bordetella显示文摘 | GZYL A AUGUSTYNOWICZ E MOSIEJ E | 2005 | J Med Microbiol2005，54，4： | 1 |
| 10 | Cryogenic insulation system for soft vacuum显示文摘 | Augustynowicz S Fesmire J | 2000 | Advances in Cryogenic Engineering2000，45，： | 1 |
| 11 | Chromium(VI) bioremediation by aquatic macrophyte callitriche cophocarpa sendtn显示文摘 | AUGUSTYNOWICZ J GROSICKI M HANUS-FAJERSKA E LEKKA M WALOSZEK A KOLOCZEK H | 2010 | Chemosphere2010，79，： | 1 |
| 12 | Application of polymerase chain reaction (PCR) for the detection of DNA-HC- MV in cerebrospinal fluid of neonates and infants with cytomega- lovirus infection显示文摘 | Dzierzanowska D Augustynowicz E Gzyl A | 1997 | Neurol Neurochir Pol1997，31，3： | 1 |
| 13 | Bioavailabili- ty of rifampicin, isoniazid and pyrazinamide from fixed-dose com- bination capsules 显示文摘 | Zwo|ska Z Niemirowska H Augustynowicz E | | Int J Tuberc Lung Dis0，2，10： | 1 |
| 14 | Cryogenic insulation system for soft vacuum显示文摘 | Augustynowicz S Fesmire J | 2000 | Advances in Cryogenic Engineering2000，45，： | 1 |
| 15 | Human cytomegalovirus infection in the pre- and potnatal period with special regards to routes of infection 显示文摘 | ldzik M Milewska BB Augustynowicz E | 1996 | Pediatr Pol1996，71，6： | 1 |
| 16 | Application of polymerase chain reaction (PCR) for the detection of DNAHCMV in cerebrospinal fluid of neonates and infants with cytomegalovirus infection显示文摘 | Augustynowicz E Gzyl A | 1997 | Neurol Neurochir Pol1997，31，3： | 1 |
| 17 | Assessment of proliferative activity of thyroid Hurthle cell tumors using PCNA, Ki-67 and AgNOR methods显示文摘 | Augustynowicz A Dzieciol J Barwijuk-Machala M | 2004 | Folia Histochemica et Cytobiologica2004，42，3： | 1 |
| 18 | Technical aspects of random amplified polymorphic DNA (RAPD) technique in genotyping of bacterial strains显示文摘 | Gzyl A Augustynowicz E | 1999 | Acta Microbiol Pol1999，48，3： | 1 |
| 19 | Assessment of proliferative activity of thyroid hurthle cell tumors using PC- NA, Ki-67 and AgNOR methods显示文摘 | Augustynowicz A Dzieciol J Barwijuk-Machala M | 2004 | Folia2004，42，3： | 1 |
| 20 | Amplified fragment length polymorphism (AFLP) versus randomly amplified polymorphic DNA (RAPD) as new tools for inter- and intra-species differentiation within Bordetella 显示文摘 | Gzyl A Augustynowicz E Mosiej E | 2005 | J Med Microbiol2005，54，： | 1 |
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