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| 1 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 2 | Zinc accumulation in oysters giving mouse deaths in paralytic shellfish poisoning bioassay显示文摘 | AUNE T RAMSTAD H HEIDENREICH B | 1998 | J Shellfish Res1998，17，： | 1 |
| 3 | Oral toxicity in mice of algal toxins from the diarrheic shellfish toxin (DST) complex and associated toxins 显示文摘 | AUNE T STABELL O B NORDSTOGA K | 1998 | J Nat Toxins1998，7，2： | 1 |
| 4 | Evaluation of mustard meal as organic fertilizer on tel under field and greenhouse conditions 显示文摘 | Balesh T Zapata F Aune J B | 2005 | Nutrient Cycling in Agroecosystems2005，73，： | 1 |
| 5 | Meat consumption and the risk of type 2 diabetes:a systematic review and meta-analysis of cohort studies显示文摘 | Aune D Ursin G Veierod M B | 2009 | Diabetologia2009，52，11： | 1 |
| 6 | Determination of papralytic shellfish poisoning toxins in Norwegian shellfish by liquid chromatography with fluorescence and tandem mass spectrometry detection显示文摘 | SAYFRITZ S J AASENA A B AUNE T | 2008 | Toxicon2008，52，2： | 1 |
| 7 | Effect of mouse strain and gender on LD50 of yessotoxin显示文摘 | Tore Aune John A B Aasen Christopher O Miles | 2008 | Toxicon2008，52，： | 1 |
| 8 | In-hospital cardiac arrest-an Utstein style report of seven years experience from the Sahlgrenska University Hospital显示文摘 | Fredriksson M Aune S Thorén A B | | 0，，03： | 1 |
| 9 | Supplier involvement in in- novation processes: A taxonomy 显示文摘 | Aune T B Gressetvold E | 2011 | International Journal of Innovation Management2011，15，1： | 1 |
| 10 | Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis 显示文摘 | AUNE B HUSBY G | 1983 | Scand J Rheumatol1983，12，： | 1 |
| 11 | Relative toxicity of dinophysistoxin-2 (DTX-2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice 显示文摘 | Aune T Larsen S Aasen J A B | 2007 | Toxicon2007，49，： | 1 |
| 12 | Does ovarian stimulation for in-vitrofertilization induce a hypercoagulable state-显示文摘 | Aune B H-ie KE Oian P | 1991 | Hum Reprod1991，6，7： | 1 |
| 13 | Evaluation of the use of visual an- alogue scale in Chinese patients显示文摘 | Aun C Lam Y M Collett B | 1986 | Pain1986，25，2： | 1 |
| 14 | Screening for hemolytic and ichthyotoxic compounds of Chrysochromulina polylepis and Gyrodinium aureohum from Norwegian coastal waters 显示文摘 | YASUMOTO T UNDERDAL B AUNE T | 1990 | Toxic Marine Phytoplankton1990，46，： | 1 |
| 15 | Effect of mouse strain and gender on LD50 of yessotoxin显示文摘 | Aune T Aasen J A B Miles C O | 2008 | Toxieon2008，52，4： | 1 |
| 16 | An analysis of friendship networks,social connectedness,homesickness,and satisfaction levels of international students显示文摘 | Hendrickson B Rosen D Aune R K | 2011 | International Journal of Intercultural Relations2011，，3： | 1 |
| 17 | The anesthesia in abdominal aortic surgery(ABSENT)study:a prospective,randomized,controlled trial comparing troponin T release with fentanyl-sevoflurane and propofol-remifentanil anesthesia in major vascular surgery显示文摘 | Lindholm E E Aune E Noren C B | 2013 | Anesthesiology2013，119，4： | 1 |
| 18 | Evaluation of the use of visual analogue scale in Chinese patients显示文摘 | Aun C Lam YM Collett B | 1986 | Pain1986，25，2： | 1 |
| 19 | In-hospital cardiac arrest--an Utstein style report of seven years ex- perience from the Sahlgrenska University Hospital显示文摘 | Fredriksson M Aune S Thoren A B | 2006 | Resuscitation2006，68，3： | 1 |
| 20 | Gamma nail vs compression screw for trochanteric femoral fractures 15 reoperations in a prospective,randomized study of 378 patients显示文摘 | Aune AK Ekeland A Odegaard B | | 0，，02： | 1 |
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