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| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Music in depression: Neural correlates of emotional experience in remitted depression显示文摘AIM: To investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. METHODS: Fourteen remitted participants with a history of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric interviews(Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and one self-report scale(Beck Depression Inventory) to assess remission. Healthy control participants were interviewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. To explore psychosocialand cognitive-interpersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. RESULTS: The mean age of the sample was 54.9(± 11.3) years. There were no differences between remitted depressed(RD)(n = 14; 9 females and 5 males) and healthy participants(n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, RD participants showed reduced activations in the pregenual anterior cingulate cortex(pg ACC) in response to pleasant [parameter estimates:-0.78 vs 0.32; t(26) =-3.41, P < 0.05] and unpleasant [parameter estimates:-0.88 vs 0.56; t(26)=-4.02, P < 0.05] emotional stimuli. Linear regression analysis revealed that pg ACC activity was modulated by early life stress [β =-0.48; R2 = 0.23, F(1,27) = 7.83, P < 0.01] and taskoriented coping style [β = 0.63; R2 = 0.37, F(1,27) = 16.91, P < 0.001]. Trait anxiety modulated hippocampal responses to unpleasant stimuli [β = 0.62; R2= 0.38, F(1,27) = 15.95, P < 0.001]. Interestingly, in their reported experiences of pleasantness, arousal, happiness and fear in response to pleasant, unpleasant and neutral stimuli, RD participants did not differ significantly from healthy control participants. Adding trait anxiety or alexithymia as a covariate did not change the results.CONCLUSION: The present study indicates that, in euthymic individuals, depression history alters neural correlates, but not the subjective dimension of pleasant and unpleasant emotional experiences. | Sabine Aust Karin Filip Stefan Koelsch Simone Grimm Malek Bajbouj | 2013 | World Journal of Psychiatry2013，3，2： | 3 |
| 3 | Grain boundary character distribution and intergranular corrosion behavior in high purity aluminum显示文摘 | S.H Kim U Erb K.T Aust G Palumbo | 2001 | Scripta Materialia2001，，5： | 2 |
| 4 | Aktualisierte Leitlinie zur Diagnostik und Therapie der Colitis ulcerosa 2011 – Ergebnisse einer Evidenzbasierten Konsensuskonferenz显示文摘 | A. Dignass J. Prei? D. Aust F. Autschbach A. Ballauff G. Barretton B. Bokemeyer S. Fichtner-Feigl S. Hagel K. Herrlinger G. Jantschek A. Kroesen W. Kruis T. Kucharzik J. Langhorst M. Reinshagen G. Rogler D. Schleiermacher C. Schmidt S. Schreiber H. Schulz | 2011 | Z Gastroenterol2011，，09： | 2 |
| 5 | Purse-string suture technique to enable laparoscopic management of the interstitial gestation of a heterotopic pregnancy显示文摘 | Thomas Aust Aoife O’Neill Gregory Cario | 2011 | Fertility and Sterility2011，，1： | 2 |
| 6 | A grain boundary characterization study of boron segregation and carbide precipitation in alloy 304 austenitic stainless steel 显示文摘 | Kurban M Erb U Aust K T | 2006 | Scripta Mater2006，54，： | 1 |
| 7 | The GRE Advanced Test in Computer Science 显示文摘 | R H Austing | 1997 | Communication of ACM1997，20，9： | 1 |
| 8 | On a More Restrictive Geometric Criterion for 'Special' CSL Grain Boundaries显示文摘 | Palumbo G Aust K T Lehockey E M | 1998 | Scr Mater1998，38，11： | 1 |
| 9 | Detection of Phanerochaete chrysosporiumin soil by PCR and restriction enzyme analysis显示文摘 | Johnston CG Aust SD | 1994 | Appl EnvironMicrobiol1994，60，7： | 1 |
| 10 | Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome显示文摘 | Ott J Aust S Kurz C | 2010 | Fertil Steril2010，94，7： | 1 |
| 11 | Interface control for resistance to intergranular cracking 显示文摘 | Aust K T Erb U Palumbo G | 1994 | Mater Sci Eng A1994，176，12： | 1 |
| 12 | The effect of starting nanostructure on the thermal stability of electrodeposited nanocrystalline Co 显示文摘 | HIBBARD G D AUST K T ERB U | 2006 | Acta Materialia2006，54，9： | 1 |
| 13 | Intestinal microvascular malformations and congenital asplenia in an adolescent possibly expanding the phenotype of Ivemark syndrome显示文摘 | Wurfel C Bruckner S Aust DE | 2011 | Eur J Gastro- enteml Hepatol2011，23，12： | 1 |
| 14 | Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)—proposal for diagnostic criteria显示文摘 | Daniela E. Aust Gustavo B. Baretton | 2010 | Virchows Archiv2010，，3： | 1 |
| 15 | Brain cell death ical sequence显示文摘 | Krause GS White BC Aust GW | 1988 | Crit Care Med1988，16，： | 1 |
| 16 | Differential expres sion and activity status of MMP 1, MMP-2 and MMP 9 in tumor and stromal cells of squamous cell carcinomas of the lung显示文摘 | Schutz A Schneidenbach D Aust G | 2002 | Tumour Biol2002，23，3： | 1 |
| 17 | Mechanisms White Rot Fungi Use to Degrade Pollutants 显示文摘 | Barr D P Aust S D | 1994 | Environ Sei Technol1994，28，2： | 1 |
| 18 | Surgical considerations in the Hartmann's procedure显示文摘 | Chua Cl Aust NZ | 1996 | J Surg1996，66，： | 1 |
| 19 | Treatment of psoriasis with the chimeric monoclonal antibody against tumor necrosis factor alpha,infliximab显示文摘 | Schopf RE Aust H Knop J | 2002 | J Am Acad Dermatol2002，46，6： | 1 |
| 20 | The relationship between hardness and abrasive wear resistance of electrodeposited nanocrystalline Ni - P coatings 显示文摘 | Jeong D H Erb U Aust K T | 2003 | Scripta Materialia2003，48，： | 1 |
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