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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Cranioplasty: cosmetic or therapeutic 显示文摘 | Dujovny M Aviles A Agner C el al | 1997 | Surg Neurol1997，47，： | 1 |
| 3 | Surveillance of methicillin - resistant Staphylococcus aureus in a pediatric hospital in Mexico City during a 7 - year period ( 1997 to 2003) : clonal evolution and impact of infection control显示文摘 | Velazquez - Meza ME Aires de Sousa M Echaniz - Aviles G | 2004 | J Clin Microbiol2004，42，8： | 1 |
| 4 | Determination of alkylphenol and alkylphenolethoxylates in biota by liquid chro- matography with detection by tandem mass spec- trometry and fluorescence spectroscopy显示文摘 | Schmitz-Afonso I Loyo-Rosales J E de la Paz Aviles M | 2003 | Jour- nal of Chromatography A2003，1010，1： | 1 |
| 5 | Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of space flight conditions 显示文摘 | Aviles H Belay T Vance M | 2004 | J Appl Physiol2004，97，： | 1 |
| 6 | Statins promote potent systemic antioxid effects through specific inflammatory pathways显示文摘 | SHISHEHBOR M H BRENNAN M L AVILES R J | 2003 | Circulation2003，108，4： | 1 |
| 7 | The role of genotype in 104 cases of diffuse large B-cell lymphoma primary of breast显示文摘 | Aviles A Neri N Nambo M J | 2012 | Am J Clin Oncol2012，35，2： | 1 |
| 8 | Hypokalemia alters sex hormone and gonadotropin levels:evidence that FSH may be required for luteinization显示文摘 | Tejada F Cremades A Aviles M | 1998 | Endocrino Metab1998，38，： | 1 |
| 9 | Cold stress-induced modulation of cell immunity during acute Toxoplasma gondi infection in mice显示文摘 | Banerjee S K Aviles H Fox M T | 1999 | J Parasitol1999，85，3： | 1 |
| 10 | Primary breast lympho- ma: results of a controlled clinical trial 显示文摘 | Aviles A Delgado S Nambo M J | 2005 | Oncology2005，69，3： | 1 |
| 11 | First report of Macrophomina phaseolina causing crown and root rot of strawberry in Spain显示文摘 | Avilés M Castillo S Bascon J | 2008 | Plant Pathology2008，57，： | 1 |
| 12 | The role of surgery in primary gastric lymphoma : results of a controlled clinical trial 显示文摘 | Aviles A Nambo M J Neri N | 2004 | Ann Surg2004，240，1： | 1 |
| 13 | Effects of space flight conditions on the function of the immune system and catecholamine production simulated in a rodent model of hindlimb unloading显示文摘 | Aviles H Belay T Vance M | | 0，，03： | 1 |
| 14 | Experimental support for the use of egg uniformity in parasite egg discrimination by cuckoo hosts显示文摘 | Moskát C Avilés JM Bán M Hargitai R Z(o)lei A | | 0，，： | 1 |
| 15 | Primary breast lymphoma: results of a controlled clinical trial显示文摘 | Aviles A Delgado S Nambo M J | 2005 | Oncology2005，69，3： | 1 |
| 16 | The Role of Surgery in Primary Gastric Lymphoma: Results of a Controlled Clinical Trial显示文摘 | Aviles A Nambo M J Neri N | 2004 | Ann Surg2004，240，1： | 1 |
| 17 | Novel therapy in multiple myeloma显示文摘 | Aviles A Neri N Nambo M J | 2005 | Invest New Drugs2005，23，5： | 1 |
| 18 | Thermal study of the effect of several solvents on polymerization of acrylonitrile and their subsequent pyrolysis显示文摘 | Sanchez-Soto P J Aviles M A del Rio J C | 2001 | Journal of analytical and applied pyrolysis2001，5859，： | 1 |
| 19 | Myringo- plasty : auditory follow-up and study of prognostic factors 显示文摘 | Aviles Jurado FJ Meran Gil JL Tobed Secall M | 2009 | Acta Otorrinolaringol Esp2009，60，3： | 1 |
| 20 | Allergic vulvovaginitis in infancy:study of a case显示文摘 | GARCIA- AVILES C CARVALHO N FERNANDEZ- BENI- TEZ M | 2001 | Allergol Immunopathol (Madr)2001，29，： | 1 |
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