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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | A systematic review of early versus delayed wound closure in patients with open fractures requi- ting flap coverage 显示文摘 | Wood T Sameem M Avram R | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 3 | Oxidation of phenylyclohexane to hydroper-oxide in the presence of cobalt acetylacetonate 显示文摘 | Loan C Avram R Lovu H | 1995 | Revista de Chimie1995，46，9： | 1 |
| 4 | The Pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment 显示文摘 | De Wolf AM Rangen R J Avram M J | 2001 | Anesth Analg2001，93，5： | 1 |
| 5 | Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 6 | The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment 显示文摘 | De Wolf AM Fragen R J Avram MJ | 2001 | Anesth Analg2001，93，5： | 1 |
| 7 | Accurately communicating the extent of a hair transplant procedure: a proposal of a follicular-based classifica-tion scheme 显示文摘 | Avram M R | 1997 | Dermatol Surg1997，23，9： | 1 |
| 8 | Hemodynamic consequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1988 | Am J Kidney Dis1988，12，： | 1 |
| 9 | A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species 显示文摘 | VASKEN APOSHIAN H ZAKHARYAN R A AVRAM M D | 2004 | Toxicol Appl Pharmacol2004，198，3： | 1 |
| 10 | Russian and American put options under exponential phase type L6vy models显示文摘 | Asmussen S Avram F Pistorius M R | 2004 | Stochastic Processes and their Applications2004，109，： | 1 |
| 11 | Predictive value of nutritional markers(albumin,creatinine,cholesterol,and hematocrit)for patients on dialysis for up to 30 years显示文摘 | Avram MM Bonomini LV Sreedhara R | 1996 | Am J Kidney Dis1996，28，： | 1 |
| 12 | Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia显示文摘 | Sreedhara R Avram DK | 1996 | Am J Kidney Dis1996，28，6： | 1 |
| 13 | Prognostic value of enrollment nutritional markers including novel predictors PTH and prealbumin in hemodialysis patients: 12 years of follow-up显示文摘 | Avram MM Sreedhara R Oo KK | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 14 | Electrically induced protoplast fusion for ergosterol-producing yeast strain improvement显示文摘 | Avram D Petcu I Radu M Dan F Stan R | 1992 | Basic Microbiol1992，32，6： | 1 |
| 15 | A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsen ic species显示文摘 | A poshianH V Zakharyan R A Avram MD | 2004 | Tox-cology and Applied Pharmacology2004，198，1： | 1 |
| 16 | Hemodynamic consequences of continuous arterio-venous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 17 | Weight loss in mildly to moderately obese patients with obstructive sleep apnea显示文摘 | Philip L Smith Avram R | 1985 | Annals of Internal Medicine1985，103，： | 1 |
| 18 | A systematic review of early versus delayed wound closure in patients with open fractures requiring flap coverage显示文摘 | Wood T Sameem M Avram R | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 19 | The pharma-cokinetics of Dexmedetomidine in volunteers with severe renal impairment 显示文摘 | De Wolf AM Fragen R J Avram M J | 2001 | Anesthesia & Analegsia2001，93，： | 1 |
| 20 | A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species 显示文摘 | Vasken Aposhian H Zakharyan R A Avram M D | 2004 | Toxicology and applied Pharmacology2004，198，3： | 1 |
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