| 2 | Microalbuminuria in hepatitis C-genotype 4:Effect of pegylated interferon and ribavirin显示文摘AIM:To study the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria and renal impairment in relation to hepatic histology, and viremia in the absence of cryoglobulinemia, and to examine the effect of treatment on microalbuminuria.METHODS: Three hundred subjects, including 233 HCV genotype-4 infected patients, were tested for cryoglobulinemia, microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine, and estimated glomerular filtration rate (eGFR). The parameters were measured again in the HCV patients after 48 wk of treatment with pegylated interferon and ribavirin.RESULTS: Significantly higher levels of microalbumin- uria were detected in HCV-positive patients compared to HCV-negative controls (median 9.5 vs 5.9, respectively, Kruskal-Wallis P=0.017). Log microalbuminuria was significantly correlated with hepatic inflammation (r=0.13, P=0.036) and f ibrosis (r=0.12, P=0.061), but not with viral load (r=-0.03, P=0.610), or alanine transaminase (r=-0.03, P=0.617). Diabetes mellitus neither significantly moderated (χ2=0.13, P=0.720), nor mediated (Sobel test P=0.49) the HCV effect. HCV status was signifi cantly associated with log microalbu-minuria (χ2=4.97, P=0.026), adjusting for age, gender, diabetes, cryoglobulinemia, urea and creatinine. A positive HCV status was not significantly associated with low eGFR (<60 mL/min every 1.73 m2) [odds ratio (OR): 0.5, 95% confidence interval (CI):0.2-1.4], nor with high ACR (OR: 1.7, 95% CI:0.7-4.1). End-of-treatment response (ETR) was achieved in 51.9% of patients. Individuals with ETR had significantly lower microalbuminuria post-treatment (χ2=8.19, P=0.004).CONCLUSION: HCV affected the development of microalbuminuria independent of diabetes or cryoglobulinemia. Combination therapy of pegylated interferon-ribavirin had a positive effect in reducing microalbuminuria. | Moutaz Derbala Fatma M Shebl Awad Rashid Aliaa Amer Abdulbari Bener | 2010 | World Journal of Gastroenterology2010，16，10： | 0 |
| 3 | Data Reliability and Sensors Lifetime in Bridge Health Monitoring using LoRaWAN-Zigbee显示文摘The Wireless Sensor Network(WSN)is regarded as the fastest expanding technological trend in recent years due its application in a variety of sectors.In the monitoring region,several sensor nodes with various sensing capabilities are installed to gather appropriate data and communicate it to the gateway.The proposed system of the heterogeneous WSN employing LoRaWAN-Zigbee based hybrid communication is explored in this research study.To communicate in a network,two Long–Range Wide Area Network(LoRaWAN)sensor clusters and two Zigbee sensor clusters are employed,together with two Zigbee and LoRaWAN converters.The suggested Golden eagle shepherd optimization(GESO)method then forms Zigbee as well as LoRaWAN networking clusters.Furthermore,depending on energy usage and data packet size,the fitness of each sensor node is assessed using the Dynamic Intelligent Reasoning Based Neural(DIRN)approach.MATLAB software is used to implement and execute this study.When the Zigbee network’s transmission distance is 650 m and the LoRaWAN network’s transmission range is 3.5 km,the system can function with a packet loss rate of less than 0.04 percent.This study shows significant gains in the performance of the system when compared to traditional approaches based on digital findings obtained on software solutions. | Awad Ali Reyazur Rashid Irshad Ahmed Abdu Alattaab Aamir Fatahayab | 2022 | Computers, Materials & Continua2022，，11： | 0 |
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