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| 1 | Recent advances on the association of apoptosis in chronic non healing diabetic wound显示文摘Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and diseases that cause ischemia. Chronic wounds are rapidly increasing among the elderly population with dysfunctional valves in their lower extremity deep veins, ulcer, neuropathic foot and pressure ulcers. The process of the healing of wounds has several steps with the involvement of immune cells and several other cell types. There are many evidences supporting the hypothesis that apoptosis of immune cells is involved in the wound healing process by ending inflammatory condition. It is also involved in the resolution of various phases of tissue repair. During final steps of wound healing most of the endothelial cells, macrophagesand myofibroblasts undergo apoptosis or exit from the wound, leaving a mass that contains few cells and consists mostly of collagen and other extracellular matrix proteins to provide strength to the healing tissue. This review discusses the various phases of wound healing both in the chronic and acute wounds especially during diabetes mellitus and thus support the hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus and gives proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients. | Awadhesh K Arya Richik Tripathi Santosh Kumar Kamlakar Tripathi | 2014 | World Journal of Diabetes2014，5，6： | 14 |
| 2 | Genome-Wide Organization and Expression Profiling of the NAC Transcription Factor Family in Potato (Solanum tuberosum L.)显示文摘 | Anil Kumar Singh Vishal Sharma Awadhesh Kumar Pal Vishal Acharya Paramvir Singh Ahuja | 2013 | DNA Research2013，，4： | 2 |
| 3 | A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma显示文摘 | Sushila Jaiswal Mukul Vij Dinesh Rajput Anant Mehrotra Awadhesh Kumar Jaiswal Arun Kumar Srivastava Sanjay Behari Narendra Krishnani | 2010 | Journal of Clinical Neuroscience2010，，3： | 1 |
| 4 | Metabolic and cardiovascular benefits with combination therapy of SGLT-2 inhibitors and GLP-1 receptor agonists in type 2 diabetes显示文摘Both GLP-1 receptor agonists(GLP-1RA)and SGLT-2 inhibitors(SGLT-2I)are newer classes of anti-diabetic agents that lower HbA1c moderately and decrease body weight and systolic blood pressure(SBP)modestly.Combination therapy with GLP-1RA plus SGLT-2I have shown a greater reduction in HbA1c,body weight,and SBP compared to either agent alone without any significant increase in hypoglycemia or other side effects.Since several agents from each class of these drugs have shown an improvement in cardiovascular(CV)and renal outcomes in their respective cardiovascular outcome trials(CVOT),combination therapy is theoretically expected to have additional CV and renal benefits.In this comprehensive opinion review,we found HbA1c lowering with GLP-1RA plus SGLT-2I to be less than additive compared to the sum of HbA1c lowering with either agent alone,although body weight lowering was nearly additive and the SBP lowering was more than additive.Our additional meta-analysis of CV outcomes with GLP1RA plus SGLT-2I combination therapy from the pooled data of five CVOT found a similar reduction in three-point major adverse cardiovascular events compared to GLP-1RA or SGLT-2I alone,against placebo.Interestingly,a greater benefit in reduction of heart failure hospitalization with GLP-1RA plus SGLT-2I combination therapy was noted in the pooled meta-analysis of two randomized controlled trials.Future adequately powered trials can confirm whether additional CV or renal benefit is truly exerted by GLP-1RA plus SGLT-2I combination therapy. | Awadhesh Kumar Singh Ritu Singh | 2022 | World Journal of Cardiology2022，14，6： | 1 |
| 5 | Specifying mobile network using a wp-like formal approach 显示文摘 | Awadhesh Kumar Singh Umesh Ghanekar Anup Kumar Bandyopadhyay | 2005 | Revista Colombiana de Computacion2005，6，2： | 1 |
| 6 | Relook at DPP-4 inhibitors in the era of SGLT-2 inhibitors显示文摘SGLT-2 inhibitors(SGLT-2Is)have significantly improved cardio-renal outcomes and are preferred agents in people with cardiovascular diseases,heart failure,and diabetic kidney disease.Similarly,GLP-1 receptor agonists(GLP-1RAs)have significantly improved atherosclerotic cardiovascular outcomes.To this end,DPP-4 inhibitors(DPP-4Is)are cardiac-neutral drugs.While long-acting GLP-1RAs have shown a favorable HbA1c lowering compared to DPP-4Is,there is no clinically meaningful HbA1c lowering difference between SGLT-2Is vs DPP-4Is.Moreover,the glucose-lowering potential of SGLT-2Is gets compromised with a progressive decline in renal functions,unlike DPP-4Is.Furthermore,the HbA1c lowering potential of DPP-4Is is favorable in people with T2DM having a modest baseline HbA1c(8.0%-8.5%)compared with SGLT-2Is which lowers HbA1c larger in a background of higher baseline HbA1c(>8.5%-9.0%).These findings suggest that the role of DPP-4Is in the management of type 2 diabetes mellitus cannot be completely ignored even in the era of SGLT-2Is. | Awadhesh Kumar Singh Ritu Singh | 2022 | World Journal of Diabetes2022，13，6： | 0 |
| 7 | Genetic Dissection of Grain Size Traits Through Genome-Wide Association Study Based on Genic Markers in Rice显示文摘Grain size plays a significant role in rice,starting from affecting yield to consumer preference,which is the driving force for deep investigation and improvement of grain size characters.Quantitative inheritance makes these traits complex to breed on account of several alleles contributing to the complete trait expression.We employed genome-wide association study in an association panel of 88 rice genotypes using 142 new candidate gene based SSR(cgSSR)markers,derived from yield-related candidate genes,with the efficient mixed-model association coupled mixed linear model for dissecting complete genetic control of grain size traits.A total of 10 significant associations were identified for four grain size-related characters(grain weight,grain length,grain width,and length-width ratio).Among the identified associations,seven marker trait associations explain more than 10%of the phenotypic variation,indicating major putative QTLs for respective traits.The allelic variations at genes OsBC1L4,SHO1 and OsD2 showed association between 1000-grain weight and grain width,1000-grain weight and grain length,and grain width and length-width ratio,respectively.The cgSSR markers,associated with corresponding traits,can be utilized for direct allelic selection,while other significantly associated cgSSRs may be utilized for allelic accumulation in the breeding programs or grain size improvement.The new cgSSR markers associated with grain size related characters have a significant impact on practical plant breeding to increase the number of causative alleles for these traits through marker aided rice breeding programs. | Amrit Kumar NAYAK Anilkumar C Sasmita BEHERA Rameswar Prasad SAH Gera Roopa LAVANYA Awadhesh KUMAR Lambodar BEHERA Muhammed Azharudheen TP | 2022 | Rice science2022，29，5： | 0 |
| 8 | Renin-angiotensin system blockers-SGLT2 inhibitorsmineralocorticoid receptor antagonists in diabetic kidney disease:A tale of the past two decades!显示文摘Several pharmacological agents to prevent the progression of diabetic kidney disease(DKD)have been tested in patients with type 2 diabetes mellitus(T2DM)in the past two decades.With the exception of renin-angiotensin system blockers that have shown a significant reduction in the progression of DKD in 2001,no other pharmacological agent tested in the past two decades have shown any clinically meaningful result.Recently,the sodium-glucose cotransporter-2 inhibitor(SGLT-2i),canagliflozin,has shown a significant reduction in the composite of hard renal and cardiovascular(CV)endpoints including progression of end-stage kidney disease in patients with DKD with T2DM at the top of reninangiotensin system blocker use.Another SGLT-2i,dapagliflozin,has also shown a significant reduction in the composite of renal and CV endpoints including death in patients with chronic kidney disease(CKD),regardless of T2DM status.Similar positive findings on renal outcomes were recently reported as a top-line result of the empagliflozin trial in patients with CKD regardless of T2DM.However,the full results of this trial have not yet been published.While the use of older steroidal mineralocorticoid receptor antagonists(MRAs)such as spironolactone in DKD is associated with a significant reduction in albuminuria outcomes,a novel non-steroidal MRA finerenone has additionally shown a significant reduction in the composite of hard renal and CV endpoints in patients with DKD and T2DM,with reasonably acceptable side effects. | Awadhesh Kumar Singh Ritu Singh | 2022 | World Journal of Diabetes2022，13，7： | 0 |
| 9 | Bed dynamics of gas-solid fluidized bed with rod promoter显示文摘The dynamic characteristics of a gas-solid fluidized bed with different rod promoters have been investigated in terms of bed expansion and fluctuation, minimum fluidization velocity and distributor-to-bed pressure drop ratio at minimum fluidization velocity. Experimentation based onstatistical design has been carried out and model equations using factorial design of experiments have been developed for the above mentionedquantities for a promoted gas-solid fluidized bed. The model equations have been tested with additional experimental data. The system variablesinclude four types of rod promoters of varying blockage volume, bed particles of four sizes and four initial static bed heights. A comparisonbetween the predicted values of the output variables using the proposed model equation with their corresponding experimental ones shows fairlygood agreement. | Awadhesh Kumar Gopendra K.Roy | 2007 | China Particuology2007，5，4： | 0 |
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