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| 1 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats显示文摘瞄准:在老鼠在导致 caerulein 的胰腺炎和联系肝损伤上处于导致胰腺炎的肝的损坏和象 melatonin,抗坏血酸和 N 乙酰半胱氨酸那样的抗氧化剂代理人的效果调查氧化损害的角色。方法:38 只女 Wistar 老鼠被使用。尖锐胰腺炎(AP ) 被 caerulein 的二 i.p 注射在 2-h 间隔导致(在 100 microg/kg b.wt 的全部的剂量) 。另外的二个组收到了另外的 melatonin (20 mg/kg b.wt ) 或包含 L (+) 维生素酸(14.3 mg/kb.wt.) 和 N 乙酰半胱氨酸(181 mg/kg b.wt ) 的抗氧化剂混合物立即在 caerulein 的每注射前的 i.p。老鼠被斩首杀头 12 h 在 caerulein 的最后注射以后牺牲。胰腺、肝的氧化压力标记被变化在在织物抗氧化剂酶层次,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GPx ) 作为 malondialdehyde (MDA ) 和变化测量的类脂化合物过氧化物的数量评估。组织病理学说的检查用获得系统被执行。结果:肝的房间退化,细胞内部的空泡形成,脉管的拥挤,正弦曲线膨胀和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.001 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。ciner 房间退化,胰腺的浮肿,细胞内部的空泡形成和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.004 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。 导致Caerulein 胰腺并且肝损坏伴有织物 MDA 层次的重要增加( P = 0.01 , P = 0.003 ,分别地)而在猫的重要减少( P = 0.002 , P = 0.003 ,分别地)并且 GPx 活动( P = 0.002 , P = 0.03 ,分别地)。Melatonin 和 L (+) 维生素 acid+N 乙酰半胱氨酸管理显著地减少了在胰的 MDA 层次(P=0.03, P=0.002,分别地) 并且肝(P = 0.007, P = 0.01,分别地) 。这些代理人的管理增加了胰腺、肝的猫和 GPx 活动。Melatonin 显著地增加了胰腺、肝的猫(P = 0.002, P = 0.001,分别地) 并且 GPx 活动(P = 0.002, P = 0.001 ) 。另外, L (+) 维生素酸 +N 乙酰半胱氨酸显著地增加了胰腺的 GPx (P = 0.002 ) 并且肝的猫和 GPx 活动(P = 0.001, P = 0.007,分别地).CONCLUSION:氧化损害不仅在 AP 的致病而且处于导致胰腺炎的肝的损坏起一个重要作用。抗氧化剂代理人象 melatonin 和抗坏血酸 +N 乙酰半胱氨酸那样,能够限制经由恢复织物抗氧化剂酶活动在 AP 期间生产的胰腺、肝的损坏。 | Mukaddes E■refoglu Mehmet Gül Burhan Ate■ Kadir Batoglu Mukadder Ay■e Selimoglu | 2006 | World Journal of Gastroenterology2006,12,2: | 29 |
| 2 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012,,4: | 3 |
| 3 | 肺动脉高压患者的负荷适应性显示文摘已知右心室对压力超负荷的适应是肺动脉高压(pulmonary arterial hypertension,PAH)患者预后的主要影响因素。为了评估右心室适应和负荷之间的关系,然后比较PAH中不同负荷适应性指数的预后价值,Amsallem及其同事纳入推导队列(n=85)和验证队列(n=200),使用3种方法评估负荷适应性:①脑室动脉耦合的替代物(例如右心室面积变化/收缩末期面积); | 刘莉 叶鹏 Amsallem M Boulate D Aymami M Guihaire J Selej M Huo J Denault AY McConnell MV Schnittger I Fadel E Mercier O Zamanian RT Haddad F | 2017 | 中华高血压杂志2017,25,8: | 2 |
| 4 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007,7,3: | 2 |
| 5 | Medically important bacteri- al-fungal interactions 显示文摘 | Peleg AY Hogan DA Mylonakis E | 2010 | Nat Rev Microbiol2010,8,5: | 1 |
| 6 | Exposure to low outdoor temperature in the midtrimester is associated with low birth weight显示文摘 | Ay E Uyar E | 2004 | Aust N Z J Obstet Gynaecol2004,44,: | 1 |
| 7 | Intrahepatic cholestasis of pregnancy in women with a multiple pregnancy : an analysis of risks and pregnancy outcomes 显示文摘 | Lausman AY A1-Yaseen E Sam D | 2008 | J Obstet Gynaecol Can2008,30,11: | 1 |
| 8 | Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: theCIP model显示文摘 | Ay H Arsava E M Johnston S C | 2009 | Stroke2009,40,: | 1 |
| 9 | Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis:A preliminary report显示文摘 | AY ZY BERKER E | 2006 | Cytokine2006,35,34: | 1 |
| 10 | Finite element modeling of transmission line under downburst wind loading显示文摘 | Shehata AY Damatty A A EI Savory E | 2005 | Finite Element in Analysis and Design2005,42,: | 1 |
| 11 | The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | DE DIEGO M BROCCHI E MACK AY D | 1997 | Arch Virol1997,142,10: | 1 |
| 12 | Endovascular occlusion of vertebral arteries in the treatment of unclippable vertebrobasilar aneurysms显示文摘 | Armand AY Pierre Gobin Jonathan E | 1991 | J Neurosurg1991,74,: | 1 |
| 13 | IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation显示文摘 | Shen RR Zhou AY Kim E | | 0,,23: | 1 |
| 14 | Measure-ment of fractional flow reserve in patients with multi-vesselcoronary artery disease and borderline lesions prevents unnec-essary revascularisation procedures 显示文摘 | Reczuch K Jankowska E Telichowski Ay | 2004 | Kardiol Pol2004,60,4: | 1 |
| 15 | The montreal cognitive assessment in persons with traumatic brain injury 显示文摘 | de Guise E Alturki AY LeBlanc J | 2014 | Appl Neuropsychol Adult2014,21,2: | 1 |
| 16 | Altered Expression of BDNF and Its High-Affinity Receptor TrkB in Response to Complex Motor Learning and Moderate Exercise显示文摘 | Klintsova AY Dickson E Yoshida R | 2004 | Brain Res2004,1028,: | 1 |
| 17 | Transurethral resection of prostate with plasmakinetic energy: 100 months results of a prospectiverandomized trial 显示文摘 | Muslumanoglu AY Yuruk E Binbay M | 2012 | BJU Int2012,110,4: | 1 |
| 18 | TRAF2 is an NF-KB-activating oncogene in epithelial cancers显示文摘 | Shen RR Zhou AY Kim E | 2013 | Oncogene2013,18,: | 1 |
| 19 | Relationships among exercise capacity,hypertrophy,and left ventricular diastolic function in nonobstructive hypertrophic cardiomyopathy显示文摘 | Matsumoto Ay Arteaga E Ianni BM | 2005 | Am Heart J2005,50,1: | 1 |
| 20 | Regular Black Hole in General Relativity Coupled to Nonlinear Electrodynamics显示文摘 | AY(O)N-BEATO E GARC(I)A A | 1998 | Physical Review Letters1998,80,23: | 1 |