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您的检索式：作者名="Aziz Aamer"
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| 1 | A knowledge-driven algorithm for a rapid and automatic extraction of the hu-man cerebral ventricular system from MR neuroimages 显示文摘 | Xia Yan Hu Qingmao Aziz Aamer et cd | 2004 | Neuroimage2004，，： | 1 |
| 2 | Synthesis, Crystal Structure, Cytotoxic, Antileishmanial and Docking Evaluation of 3-(4-Chloro-3-nitrophenyl)-1-phenylprop-2-en-1-one显示文摘Chalcone derivatives are of immense importance owing to their superior pharmacological profile. Minor changes in their structures create high degree of diversity that results in a broader spectrum of biological activities. The present research paper presents the synthesis of 3-(4-chloro-3-nitrophenyl)-1-phenylprop-2-en-1-one chalcone(I), single crystal XRD analysis and the evaluation of its possible biological activities like cytotoxic(LD_(50) = 5.40 ug/m L)and antileishmanial(LD_(50) = 0.81 ug/m L) activities. The results indicate the tested chalcone(I)shows superior inhibition values against leishmanial promastigotes. Further, the possible interaction sites of chalcone(I) with Try R enzyme involved in the redox metabolism of the leishmanial parasite were determined using docking simulation technique. Docking computations demonstrate that the compound establishes prominent binding interactions with the key residues of Try R and possesses the potential to effectively inhibit the catalytic activities of enzyme. Thus the results suggest that the chalcone(I) can serve as a potential scaffold for the treatment of leishmaniasis and deserve further development. | HAMID Aziz AAMER Saeed FARUKH Jabeen ULRICH Florke QURAT-Ul-Ain NADHMAN Akhter | 2018 | Chinese Journal of Structural Chemistry2018，37，8： | 0 |
| 3 | Strength Evaluation of Normal Strength and Self-compacting Reinforced Concrete Beams under the Effect of Impact Loading显示文摘 | Aamer Najim Abbas Ali Hameed Aziz | 2016 | Journal of Civil Engineering and Architecture2016，10，6： | 0 |
| 4 | Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids显示文摘The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potential with a glucose-lowering effect compared to the reference drug Glibenclamide. Biochemical parameters including plasma glucose, serum triglycerides, cholesterol, alanine amino transferase and aspartate amino transferase levels showed significant alterations in concentrations relative to the control. Similarly, the derivatives 3a, 3d and 3e displayed potent in vitro antibacterial potential. Molecular docking simulations delineated that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. In silico study of the binding pattern predicted that the synthesized ligands, 3d and 3a could serve as a potential surrogate for hit-to-lead generation and the design of novel antibacterial drugs. | HAMID Aziz AAMER Saeed FARUKH Jabeen ABDUL Basit IRFAN Zia Qureshi ABDUL Aziz ATIF Haroon ASHFAQ Ur Rehman | 2021 | Chinese Journal of Structural Chemistry2021，40，3： | 0 |
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