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| 1 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 4 | Rice monitoring and production estimation using multitemporal RADARSAT显示文摘 | Yun Shao Xiangtao Fan Hao Liu Jianhua Xiao S Ross B Brisco R Brown G Staples | 2001 | Remote Sensing of Environment2001，，3： | 3 |
| 5 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 6 | Tolerance of normal tissue to therapeutic irradiation显示文摘 | Emami B Lyman J Brown A | | 0，，1： | 2 |
| 7 | Variation in fibre diameter profile characteristics between wool staple in Merino sheep 显示文摘 | Brown D J Crook B J Purvis I W | 2000 | Wool Technology and Sheep Breeding2000，，48： | 2 |
| 8 | Immobilisation of TiO2 powder for the treatment of polluted water显示文摘 | BYME J A EGGINS B R BROWN N M D | 1998 | Appl Catal B1998，17，： | 2 |
| 9 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 10 | World primary and secondary magnesium review 显示文摘 | Pawlek R P Brown R B | 2001 | Light Metal Age2001，59，8： | 2 |
| 11 | Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes 显示文摘 | Cardosa M J Perera D Brown B A | 2003 | Emerg Infect Dis2003，9，4： | 1 |
| 12 | The Cretaceous Ojo Alamo beds of New Mexico with description of the new dinosaur genus Kritosaurus显示文摘 | Brown B | 1910 | Bulletin of the American Museum of Natural History1910，28，： | 1 |
| 13 | Molecular similarity based on novel atom-type electrotopological state indices显示文摘 | Kier L B Brown B B | 1995 | J Chem Inf Comput Sci1995，35，6： | 1 |
| 14 | Net-shape forming via semi-solid processing 显示文摘 | Flemings M C | 1993 | Advanced Material and Process1993，，1： | 1 |
| 15 | China's water shortage could shake world food security显示文摘 | Brown L Halweil B | 1998 | Worldwatch1998，11，4： | 1 |
| 16 | A general model for the structure and allometry of plant vascular systems 显示文摘 | West G B Brown J H Enquist B J | 1999 | Nature1999，400，： | 1 |
| 17 | Applied potential tomography 显示文摘 | BARBER D C BROWN B H | 1984 | Phys E: Sci Instrum1984，17，9： | 1 |
| 18 | Measuring phono-logical variability from satellite imagery显示文摘 | Reed B Brown D Vanderzee D | 1994 | Joumal of Vegetation Science1994，5，5： | 1 |
| 19 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，： | 1 |
| 20 | The cost of twin pregnancy: maternal and neonatal factors 显示文摘 | Luke B Brown MB Alexandre PK | 2005 | Am J Obstet Gynecol2005，192，3： | 1 |
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