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		题名	作者	年代	出处	被引量
	1	Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical	B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN	2000	Acta Pharmacologica Sinica2000，21，12：	2

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