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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 3 | Effect of accelerated ageing on the performance of high voltage carbon/carbon electrochemical capacitors in salt aqueous electrolyte显示文摘 | Paula Ratajczak Krzysztof Jurewicz Piotr Skowron Qamar Abbas Francois Béguin | 2014 | Electrochimica Acta2014，，： | 3 |
| 4 | Characterization of ceria-zirconia solid solutions after hydrothermal ageing显示文摘 | Chrisine B Francois G Nolven G | 2001 | Applied Catalysis A2001，220，： | 2 |
| 5 | Specific genetic markers for wheat, spelt, and four wild relatives: Comparison of isozymes, RAPDs, and wheat microsatellites显示文摘 | Roberto G Dessislava S B Francois F | 2001 | Genome2001，44，4： | 1 |
| 6 | A rapid and reliable method for metabolite extraction in yeast using boiling buffered ethanol 显示文摘 | Gonzalez B Francois J Renaud M | 1997 | Yeast1997，13，14： | 1 |
| 7 | Solving Harmon- ics Elimination Problem in Three-phase Vlotage-con- trolled Inverter Using Artificial Neural Networks显示文摘 | O Bouhali M Berkouk B Francois | 2005 | Elec- trical Systems2005，1，： | 1 |
| 8 | Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens显示文摘 | Francois A Chevalier C Delmas B | 2004 | Vaccine2004，22，： | 1 |
| 9 | Successful managem ent of alarge pulmonary cement embolus after percutaneous vertebroplasty:a case report显示文摘 | Francois K Taeymans Y Poffyn B | 2003 | Spine2003，25，20： | 1 |
| 10 | Thrombocytopenia in the sepsis syndrome: Role of hemophagoeytosis and macrophage colony stimulating factor 显示文摘 | Francois B Trimoreau F Vignon P | 1997 | Am J Med1997，103，2： | 1 |
| 11 | Hospital-acquired pneumonia and ventilator-associated pneumonia recent advances in epidemiology and anagement显示文摘 | Francois B Antoine A Michel W | | 0，，03： | 1 |
| 12 | Self-organized ho?neycomb morphology of star-polymer polystyrene films显示文摘 | Widawski G Rawiso M Francois B | 1994 | Nature1994，369，： | 1 |
| 13 | Trace analysis of sulfonylurea herbicides and their metabolites in water using a combination of off- line or on-line solid-phase extraction and liquid chromatography- tandem mass spectrometry 显示文摘 | Francois P Philippe B Lucien K | 2007 | Analytical and Bioanalytieal Chemistry2007，388，56： | 1 |
| 14 | Finite element modelling of exural behaviour of externally bonded CFRP reinforced concrete structures显示文摘 | EMMANUELLE D ERIC R | 2002 | Engineering Structures2002，，24： | 1 |
| 15 | Crystal structures of complexes between aminoglycosides and decoding A site oligonucleoti- des: role of the number of rings and positive charges in the specific binding leading to miscoding显示文摘 | Francois B | 2005 | Nu- cleic Acids Res2005，33，： | 1 |
| 16 | Depression and quality of life in patients with diabetes: a systematic review from the european depression in diabetes (EDID) research consortium 显示文摘 | Miranda TS Caroline A B Francois P | 2009 | Current Diabetes Reviews2009，5，2： | 1 |
| 17 | Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial显示文摘 | Wunderink RG Laterre PF Francois B | 2011 | Am J Respir Crit Care Med2011，183，11： | 1 |
| 18 | Human mes- enchymal stem ceils provide protection against radiation - induced liv- er injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects显示文摘 | Francois S Mouiseddine M Allenet - Lepage B | 2013 | Biomed Res Int2013，2013，15： | 1 |
| 19 | Power control design of a battery charger in a hybrid active PV generator for load-following applica- tions 显示文摘 | FAKHAM H DI L FRANCOIS B | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 20 | Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer--a Groupe Tumeurs Digestives of the Federation Nationale des Centres de Lutte Contre le Cancer study显示文摘 | Conmy T Paillot B Francois E | 2005 | J Clin Oneol2005，23，6： | 1 |
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