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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 3 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 4 | CT during hepatic arteriography and portography: an illustrative review显示文摘 | Kim H C Kim T K Sung K B | 2002 | Radio Graphics2002，22，5： | 2 |
| 5 | Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells显示文摘 | Kim Y A Choi B T Lee Y T | 2004 | Oncol Rep2004，11，2： | 1 |
| 6 | Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘 | SHIN T Y LEE K B KIM S H TA Y | 2002 | Immunopharmacology & Immunotoxicology2002，24，3： | 1 |
| 7 | Properties of hot-pressed A1N/BN nanocomposites 显示文摘 | Kusunose T Sekino T Kim B S | 2003 | Materials Science Forum2003，439，： | 1 |
| 8 | Arginine-Conjugated Polypro- pylenimine Dendrimer as a Non-Toxic and Efficient Gene Delivery Carrier显示文摘 | Kim T Baek J Cheng Z B | 2007 | Biomaterials2007，，28： | 1 |
| 9 | Mechanical characteristics of light-weighted soils using dredged materials显示文摘 | YOONZ G L JEON S S KIM B T | 2004 | Marine Georesourees and Geotechnology2004，22，4： | 1 |
| 10 | Estimation of cable tension force using the frequency-based system identification method显示文摘 | KIM B H PARK T | 2007 | Journal of Sound and Vibration2007，304，6： | 1 |
| 11 | Catalyst-free growth of single-crystal silicon and germanium nanowires 显示文摘 | Kim B S Koo T W Lee J H | 2009 | Nano Lett2009，9，2： | 1 |
| 12 | The relationship of sarcoplasmic and myofibrillar protein solubility to colour and water- holding capacity in porcine longissimus muscle显示文摘 | JOO S T KAUFFMAN R G KIM B C | 1999 | Meat Science1999，52，3： | 1 |
| 13 | Effect of inclusion size on the nucleation of acicular ferrite in welds显示文摘 | Lee T K Kim H J Kang B Y | 2000 | ISIJ Int2000，40，12： | 1 |
| 14 | Deconjugation of bile salts by Lactobacillus acidophilus isolates显示文摘 | AHN Y T KIM G B LIM K S | | 0，，： | 1 |
| 15 | Role of activity inhuman dynamics显示文摘 | ZHOU T KIET HAT KIM B J | 2008 | Europhys Lett*2008，82，28： | 1 |
| 16 | Direct determination of the t matrix from a mom impedance matrix computed using the Rao Wilton Glisson basis function显示文摘 | Kim K T Kramer B A | 2013 | IEEETranson Antennas Propagation2013，61，53： | 1 |
| 17 | Analysis of magnetization of mag- net in the rotor of line start permanent magnet motor 显示文摘 | LEE C K KWON B I KIM B T | 2003 | IEEE Transactions on Magnetic2003，39，3： | 1 |
| 18 | Magnetic-field analysis on winding disposition of transformer for distributed high-speed train applications显示文摘 | PARK B G KIM T S LEE K J | 2010 | IEEE Transactions on Magnetics2010，46，6： | 1 |
| 19 | Immunogenicity of an adenoviral- based middle east respiratory syndrome coronavirus vaccine in balb/c mice显示文摘 | Kim E Okada K Kenniston T Raj V S A1Hajri M M Farag E A AIHairi F Osterhaus A D Haagmans B L Gambotto A | 2014 | Vaccine2014，32，45： | 1 |
| 20 | Endurable water-repellent glass for automobiles显示文摘 | Hong B S Han J H Kim S T | 1999 | Thin Solid Films1999，351，： | 1 |
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