| 1 | Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension显示文摘Myeloid cells,such as neutrophils,are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as pulmonary hypertension(PH).Although neutrophil recruitment into sites of inflammation has been well studied,the mechanisms of neutrophil egress from the bone marrow are not well understood.Using computational flow cytometry,we observed increased neutrophils in the lungs of patients and mice with PH.Moreover,we found elevated levels of IL-6 in the blood and lungs of patients and mice with PH.We observed that transgenic mice overexpressing Il-6 in the lungs displayed elevated neutrophil egress from the bone marrow and exaggerated neutrophil recruitment to the lungs,resulting in exacerbated pulmonary vascular remodeling,and dysfunctional hemodynamics.Mechanistically,we found that IL-6-induced neutrophil egress from the bone marrow was dependent on interferon regulatory factor 4(IRF-4)-mediated CX3CR1 expression in neutrophils.Consequently,Cx3cr1 genetic deficiency in hematopoietic cells in Il-6-transgenic mice significantly reduced neutrophil egress from bone marrow and decreased neutrophil counts in the lungs,thus ameliorating pulmonary remodeling and hemodynamics.In summary,these findings define a novel mechanism of IL-6-induced neutrophil egress from the bone marrow and reveal a new therapeutic target to curtail neutrophil-mediated inflammation in pulmonary vascular disease. | Jonathan Florentin Jingsi Zhao Yi-Yin Tai Sathish Babu Vasamsetti Scott P.O’Neil Rahul Kumar Anagha Arunkumar Annie Watson John Sembrat Grant C.Bullock Linda Sanders Biruk Kassa Mauricio Rojas Brian B.Graham Stephen Y.Chan Partha Dutta | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | 加拿大遏止结核病组织:面对实现全球结核病控制目标的挑战,发达国家大有可为显示文摘遏止结核病合作伙伴组织在实现 2005 年前达到 70%的病例发现率和 85%的病例治愈率全球目标的运动中,主要考虑如何发挥 22 个高负担国家的作用。作为传统的合作伙伴,发达国家的援助机构和政府都参加了合作伙伴组织,但其广大的国内社会被排除在外,对其国内社会的捐助者也缺乏关注。 加拿大遏止结核病组织的宗旨是发展新的合作伙伴支持加拿大政府实现 2010 年将贫穷和包括结核病的贫穷疾病降低一半目标的承诺。我们需要对所取得的成就以及面临的挑战进行进一步探索,目前出现了这样的一种可能性,即如果在所有国家开展结核病运动的话,就能够保证结核病控制支持的持续性,并保证实现结核病控制的全球目标。 | A,Fanning N.Billo T.Tannenbaum M.Phypers C.Little B.Graham J.Mill 贺晓新 屠德华 张立兴 | 2004 | 结核与肺部疾病杂志2004，7，4： | 1 |
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