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| 1 | The use of poly(styrene-block-isobutyleneblock-styrene)as a microshunt to treat glaucoma显示文摘The InnFocus MicroShuntVR is a minimally invasive glaucoma drainage microtube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon’s capsule.The safety and clinical performance of this device approaches that of trabeculectomy with mitomycin C,the current‘gold standard’treatment for advanced glaucoma.The invention of a new biomaterial called poly(styrene-block-isobutylene-block-styrene)or‘SIBS’is the enabling factor which led to the success of this product.SIBS is ultrastable with virtually no foreign body reaction in the body,which manifests as clinically insignificant inflammation and capsule formation in the eye.The lack of capsule formation enables unobstructed flow through the 70 mm lumen tube and the achievement of controlled low intraocular pressure,which is important for the management of glaucoma.This article summarizes the integration of SIBS into a glaucoma drainage device and confirms its functionality with clinical success over a 2-year period. | Leonard Pinchuk Isabelle Riss Juan F.Batlle Yasushi P.Kato John B.Martin Esdras Arrieta Paul Palmberg Richard K.Parrish Bruce A.Weber Yongmoon Kwon Jean-Marie Parel | 2016 | Regenerative Biomaterials2016，3，2： | 5 |
| 2 | Palm oil protectsα-linolenic acid from rumen biohydrogenation and muscle oxidation in cashmere goat kids显示文摘Background:In ruminants,dietary C18:3n-3 can be lost through biohydrogenation in the rumen;and C18:3n-3 that by-passes the rumen still can be lost through oxidation in muscle,theoretically reducing the deposition of C18:3n-3,the substrate for synthesis of poly-unsaturated fatty acids(n-3 LCPUFA)in muscle.In vitro studies have shown that rumen hydrogenation of C18:3n-3 is reduced by supplementation with palm oil(rich in cis-9 C18:1).In addition,in hepatocytes,studies with neonatal rats have shown that cis-9 C18:1 inhibits the oxidation of C18:3n-3.It therefore seems likely that palm oil could reduce both rumen biohydrogenation of C18:3n-3 and muscle oxidation of C18:3n-3.The present experiment tested whether the addition of palm oil to a linseed oil supplement for goat kids would prevent the losses of C18:3n-3 and thus improve the FA composition in two muscles,Longissimus dorsi and Biceps femoris.To investigate the processes involved,we studied the rumen bacterial communities and measured the mRNA expression of genes related to lipid metabolism in Longissimus dorsi.Sixty 4-month-old castrated male Albas white cashmere kids were randomly allocated among three dietary treatments.All three diets contained the same ingredients in the same proportions,but differed in their fat additives:palm oil(PMO),linseed oil(LSO)or mixed oil(MIX;2 parts linseed oil plus 1 part palm oil on a weight basis).Results:Compared with the LSO diet,the MIX diet decreased the relative abuandance of Pseudobutyrivibrio,a bacterial species that is positively related to the proportional loss rate of dietary C18:3n-3 and that has been reported to generate the ATP required for biohydrogenation(reflecting a decrease in the abundance of rumen bacteria that hydrogenate C18:3n-3 in MIX kids).In muscle,the MIX diet increased concentrations of C18:3n-3,C20:5n-3,C22:6n-3,and n-3 LCPUFA,and thus decreased the n-6/n-3 ratio;decreased the mRNA expression of CPT1β(a gene associated with fatty acid oxidation)and increased the mRNA expression of FADS1 and FADS2(genes associated with n-3 LCPUFA synthesis),compared with the LSO diet.Interestingly,compared to Longissimus dorsi,Biceps femoris had greater concentrations of PUFA,greater ratios of unsaturated fatty acids/saturated fatty acids(U/S),and poly-unsaturated fatty acids/saturated fatty acids(P/S),but a lesser concentration of saturated fatty acids(SFA).Conclusions:In cashmere goat kids,a combination of linseed and palm oils in the diet increases the muscle concentration of n-3 LCPUFA,apparently by decreasing the relative abundance of rumen bacteria that are positively related to the proportional loss rate of dietary C18:3n-3,by inhibiting mRNA expression of genes related to C18:3n-3 oxidation in muscle,and by up-regulating mRNA expression of genes related to n-3 LCPUFA synthesis in muscle,especially in Longissimus dorsi. | Xue Wang Graeme B.Martin Qi Wen Shulin Liu Yinhao Li Binlin Shi Xiaoyu Guo Yanli Zhao Yangdong Guo Sumei Yan | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 3 |
| 3 | Adaptive Wavelet Thresholding for Image Denoising and Compression显示文摘 | Chang S G Yu B.Martin V | | 0，，09： | 1 |
| 4 | Applications and advantages of virus‐induced gene silencing for gene function studies in plants显示文摘 | Tessa M.Burch‐Smith Jeffrey C.Anderson Gregory B.Martin S. P.Dinesh‐Kumar | 2004 | The Plant Journal2004，，： | 1 |
| 5 | Riboflavin and UV‐Light Based Pathogen Reduction: Extent and Consequence of DNA Damage at the Molecular Level显示文摘 | VijayKumar OwenLockerble Shawn D.Kell Patrick H.Ruane Matthew S.Platz Christopher B.Martin Jean‐LucRavanat JeanCadet Raymond P.Goodrich | 2007 | Photochemistry and Photobiology2007，，1： | 1 |
| 6 | Updated Digital Map of Mafic Dyke Swarms and Large Igneous Provinces in Western Australia显示文摘Since 1894,the Geological Survey of Western Australia(GSWA)has released 14 versions of the‘Geological Map of Western Australia’.The latest in this series,published in December 2015,is the first bedrock geology | Michael T.D.WINGATE David Mc B.MARTIN | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 0 |
| 7 | 加长刀柄仍有市场需求显示文摘位于伊利诺伊斯州Hoffman Estates的大昭和精密工具公司销售和工程副总裁Jack Burley指出,因为干涉,例如在立式加工中心上主轴前端刀具要伸进某些零件特征,需要刀柄具有较大的工作长度。Z轴的最小距离,即主轴能靠近工作台的最小距离,需由刀柄长度来补充。他指出,在卧式加工中心上,主轴能接近工作台中心的最短距离被称为死区(dead zone),也需要由刀柄来补充。 | Holly B.Martin 吴志刚(译) | 2020 | 工具展望2020，，2： | 0 |
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