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	题名	作者	年代	出处	被引量
1	T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression.	Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens	2014	World Journal of Nephrology2014，3，4：	2
2	The macrophage-derived T-cell growth factor interleukin-15 is present in interleukin-2-independent rejection after clinical heart and liver transplantation 显示文摘	Baan CC Knoop C J Holweg CT	1999	Transplant Proc1999，31，：	1
3	Regulatory T ceils contribute to the impaired immune response in patients with chronic hepatitis B virus infection 显示文摘	Stoop J N van-der-Molen R G Baan C C	2005	Hepatology2005，41，4：	1
4	Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection 显示文摘	Stoop J N van-der-Molen G R Baan C C	2005	Hepatology2005，41，4：	1
5	Regμlatory T cels contribute to the impaired immune response in patients with chronic hepatitis B virus infection显示文摘	Stoop J N van der Molen R G Baan C C	2005	Hepatology2005，41，：	1
6	Neural networks in geophysical applications显示文摘	Baan M V Jutten C	2000	Geophysics2000，65，4：	1
7	Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation 显示文摘	Crop M Baan C Weimar W	2009	Transpl Int2009，22，4：	1
8	Evaluation of the carcinogenic risks to humans associated with surgical implants and other foreign bodies-a report of an IARC Monographs Programme Meeting显示文摘	McGregor DB Baan RA Partensky C	2000	Europ J Cancer2000，36，3：	1
9	Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection显示文摘	Stoop J N Van Der Molen R G Baan C C	2005	Hepatology2005，41，：	1
10	On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation显示文摘	Engela A U Baan C C Dor F J		0，，：	1
11	Integrating care through bundled payments--lessons from the Netherlands显示文摘	STRUIJS J N BAAN C A	2011	New Englang journal of medicine2011，364，11：	1
12	Differential effect of calcineurin inhibitors,anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells显示文摘	Baan C C van der Mast B J Klepper M	2005	Transplantation2005，80，1：	1
13	Living kidney donors and hypoxia-inducible factor-1 alpha显示文摘	Baan C van Gelder T Peeters A	2003	Transplantation2003，75，4：	1
14	The robustness of seismic attenuation measurements using fixed and vari- able-window time-frequency transforms显示文摘	Reine C Van der Baan M Roger C	2009	Geophysics2009，74，2：	1
15	Isolation and characterization of dendritic cells from adenoids of children with otitis media with effusion显示文摘	VAN NIEUWKERK E B VAN DER BAAN S V RICHTERS C D	1992	Clin Exp Immunol1992，88，：	1
16	Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infeetion显示文摘	StooP J N vanderMolen R G Baan C C	2005	Hepatology2005，41，771：	1
17	Application of a dynamic in vitro gastrointestinal tract model to study the availability of food mutagens, using heterocyclic aromatic amines as model compounds显示文摘	C Krul A Luiten-Schuite R Baan H Verhagen G Mohn V Feron R Havenaar	2000	Food and Chemical Toxicology2000，，9：	1
18	Neural networks in geophysical applications 显示文摘	Baan M V D Jutten C	2000	Geophysics2000，65，4：	1
19	Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients 显示文摘	Crop M J Baan C C Korevaar S S	2009	Transplantation2009，87，6：	1
20	Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation显示文摘	CROP M BAAN C WEIMAR W	2009	Transpl Int2009，22，4：	1

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