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| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Is it better to use two elastographic methods for liver fibrosis assessment?显示文摘AIM:To find out if by combining 2 ultrasound based elastographic methods:acoustic radiation force impulse(ARFI)elastography and transient elastography(TE),we can improve the prediction of fibrosis in patients with chronic hepatitis C.METHODS:Our study included 197 patients with chronic hepatitis C.In each patient,we performed,in the same session,liver stiffness(LS)measurements by means of TE and ARFI,respectively,and liver biopsy(LB),assessed according to the Metavir score.10 LS measurements were performed both by TE and ARFI;median values were calculated and expressed in kilopascals(kPa)and meters/second(m/s),respectively.Only TE and ARFI measurements with IQR<30%andSR≥60%were considered reliable.RESULTS:On LB 13(6.6%)patients had F0,32(16.2%) had F1,52(26.4%)had F2,47(23.9%)had F3,and 53(26.9%)had F4.A direct,strong correlation was found between TE measurements and fibrosis(r=0.741),between ARFI and fibrosis(r=0.730)and also between TE and ARFI(r=0.675).For predicting significant fibrosis(F≥2),for a cutoff of 6.7 kPa,TE had 77.5% sensitivity(Se)and 86.5%specificity(Sp)[area under the receiver operating characteristic curve(AUROC)0.87] and for a cutoff of 1.2 m/s,ARFI had 76.9%Se and 86.7%Sp(AUROC 0.84).For predicting cirrhosis(F=4),for a cutoff of 12.2 kPa,TE had 96.2%Se and 89.6% Sp(AUROC 0.97)and for a cutoff of 1.8 m/s,ARFI had 90.4%Se and 85.6%Sp(AUROC 0.91).When both elastographic methods were taken into consideration,for predicting significant fibrosis(F≥2),(TE≥6.7 kPa and ARFI≥1.2 m/s)we obtained 60.5%Se,93.3% Sp,96.8%positive predictive value(PPV),41.4%negative predictive value(NPV)and 68%accuracy,while for predicting cirrhosis(TE≥12.2 kPa and ARFI≥1.8 m/s) we obtained 84.9%Se,94.4%Sp,84.9%PPV,94.4% NPV and 91.8%accuracy.CONCLUSION:TE used in combination with ARFI is highly specific for predicting significant fibrosis;therefore when the two methods are concordant,liver biopsy can be avoided. | Ioan Sporea Roxana Sirli Alina Popescu Simona Bota Radu Badea Monica Lupsor Mircea Focsa Mirela Danila | 2011 | World Journal of Gastroenterology2011，17，33： | 11 |
| 3 | 血管内皮生长因子受体3通过β抑制蛋白1调节内皮功能显示文摘受体信号转导对于维持血管内皮功能至关重要,其在动脉粥样硬化和肺动脉高压(pulmonary arterial hypertension,PAH)等血管疾病中出现失调。内皮功能相关受体信号包括血管内皮生长因子(vascular endothelial growth factor,VEGF)受体(VEGFR)和G蛋白耦联受体(G protein-coupled receptor,GPCR),激活特异的细胞内信号通路和反应。 | 刘青 叶鹏 Ma Z Yu YR Badea CT Kovacs JJ Xiong X Comhair S Piantadosi CA Rajagopal S | 2019 | 中华高血压杂志2019，27，1： | 5 |
| 4 | Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease显示文摘Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical outcome.Because of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis.The most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of diagnosis.Although they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising results.Another issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein thrombosis.In this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current guidelines.Moreover,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular circumstances.In this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients. | Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 5 | Noninvasive assessment of alcoholic liver disease using unidimensional transient elastography(Fibroscan~)显示文摘Unidimensional transient elastography(TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the factors that may influence the result of fibrosis prediction, and last but not least, on its potential use in assessing the steatosis degree. Therefore, this field is far from being exhausted and deserves more attention. Further studies are required, on large groups of biopsied patients, in order to find answers to all the remaining questions in this field. | Monica Lupsor-Platon Radu Badea | 2015 | World Journal of Gastroenterology2015，21，42： | 4 |
| 6 | Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study显示文摘 | Ioan Sporea Simona Bota Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Radu Badea Monica Lupsor Carmen Fierbinteanu-Braticevici Ana Petrisor Hidetsugu Saito Hirotoshi Ebinuma Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2012 | European Journal of Radiology2012，，12： | 3 |
| 7 | Aflatoxin M1 determination in raw milk using a flow-injection immunoassay system显示文摘 | BADEA M MICHELIA L MESSIA M C | 2004 | Analytica Chimica Acta2004，520，12： | 1 |
| 8 | New electrochemical sensors for detection of nitrites and nitrates显示文摘 | Badea M Amine A Palleschi G | 2001 | Journal of Electroanalytical Chemistry2001，509，1： | 1 |
| 9 | Quantitative endoskopische kontrastverst?rkte harmonische Sonografie zur Differenzierung solider Pankreastumoren显示文摘 | A. Seicean R. Badea R. Stan-Iuga T. Mocan I. Gulei O. Pascu | 2010 | Ultraschall in Med2010，，06： | 1 |
| 10 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screenprinted electrodes显示文摘 | MICHELI L GRECCO R BADEA R | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 11 | Numerical Analysis of Permanent Magnet DC Motor Performances 显示文摘 | Craiu O Dan N Badea E A | 1995 | IEEE Transactions on Magnetics1995，31，6： | 1 |
| 12 | Thermal behavior, spectroscopic and biological characterization of Co(II), Zn(II), Pd(II) and Pt(II) complexes with N,N-dimethylbiguanide显示文摘 | Rodica Olar M. Badea E. Cristurean V. Lazar R. Cernat C. Balotescu | 2005 | Journal of Thermal Analysis and Calorimetry2005，，2： | 1 |
| 13 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screen-printed electrodes 显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosens Bioelectron2005，21，4： | 1 |
| 14 | Investigation into iron tanning 显示文摘 | Gaidau C Platon F Badea N | 1998 | JSLTC1998，82，4： | 1 |
| 15 | Flow analysis for determination of paraoxon with use of immobilized acetylcholinesterase reactor and new type of chemiluminescent reaction显示文摘 | Andrei F Badea M Marty J L | 2000 | Biopolymers2000，57，1： | 1 |
| 16 | Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats显示文摘 | King M J Badea I Solomon J | 2002 | Diabetes Technol Ther2002，4，4： | 1 |
| 17 | In vivo cutaneous interferon -gamma gene delivery using novel dicationic ( gemini ) surfactant - plasmid complexes 显示文摘 | Badea I Verrall R Baca - Estrada M | 2005 | J Gene Med2005，7，： | 1 |
| 18 | An Electrochemical Immunosensor for Aflatoxin M1 Determinantion in Milk Using Screen-Printed Electrodes显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 19 | Contrast-enhanced ultrasonography represents a very good method in the assessment of liver masses 显示文摘 | Badea R | 2011 | Med Ultrason2011，13，2： | 1 |
| 20 | Performance of a new elastographie method (ARFI technology) compared to unidimensioual transient elastography in the noninvasive assessment of chronic hepatitis C: preliminary results 显示文摘 | Lupsor M Badea R Stefanescu H | 2009 | J Gastrointest Liver Dis2009，18，3： | 1 |
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