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| 1 | The geographical agglomeration-private R&D expenditure effect:empirical evidence on Italian data显示文摘 | BAGELLA M BECEHETTI L | | 0，，03： | 1 |
| 2 | From GO to S phase:a view of the roles played by the retinoblastoma(Rb)family members in the Rb-E2F pathway显示文摘 | Sun A Bagella L Tutton S | 2007 | J Cell Biochem2007，102，6： | 1 |
| 3 | Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A显示文摘 | Tonini T Bagella L DAndrilli G | 2004 | Oncogene2004，23，28： | 1 |
| 4 | From Go to S phase:A view of the roles played by the retinoblastoma (Rb) family members in the Rb- E2F pathway显示文摘 | Sun A Bagella L Tutton S | 2007 | J Cell Biochem2007，102，6： | 1 |
| 5 | Study of viral integration of HPV-16 in young patients with LSIL 显示文摘 | Gallo G Bibbo M Bagella L | 2003 | J Clin Pathol2003，56，7： | 1 |
| 6 | From GO to S Phase:a view of the roles played by the retinoblastoma(Rb) family members in the Rb - E2 F pathway 显示文摘 | Sun A Bagella L Tutton S | 2007 | J Cell Biochem2007，102，6： | 1 |
| 7 | Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities显示文摘 | Skerlavaj B Gennaro R Bagella L | 1996 | J Biol Chem1996，271，28： | 1 |
| 8 | The determinants of motion picture box office performance:Evidence from movies produced in Italy显示文摘 | Bagella M Becchetti L | | 0，，： | 1 |
| 9 | Viral infections as a cause of cancer (review) 显示文摘 | Carrillo-Infante C Abbadessa G Bagella L | 2007 | Int J Oncol2007，30，6： | 1 |
| 10 | EZH2 reduces the ability of HDACl-dependent pRb2/pl30 transcriptional repression of cyclinA显示文摘 | Tonini T Bagella L D'Andrilli G | 2004 | Oncogene2004，23，28： | 1 |
| 11 | Targeting Enhancer of Zeste Homolog 2 as a promising strategy for cancer treatment显示文摘Polycomb group proteins represent a global silencing system involved in development regulation.In specific,they regulate the transition from proliferation to differentiation,contributing to stem-cell maintenance and inhibiting an inappropriate activation of differentiation programs.Enhancer of Zeste Homolog 2(EZH2) is the catalytic subunit of Polycomb repressive complex 2,which induces transcriptional inhibition through the tri-methylation of histone H3,an epigenetic change associated with gene silencing.EZH2 expression is high in precursor cells while its level decreases in differentiated cells.EZH2 is upregulated in various cancers with high levels associated with metastatic cancer and poor prognosis.Indeed,aberrant expression of EZH2 causes the inhibition of several tumor suppressors and differentiation genes,resulting in an uncontrolled proliferation and tumor formation.This editorial explores the role of Polycomb repressive complex 2 in cancer,focusing in particular on EZH2.The canonical function of EZH2 in gene silencing,the non-canonical activities as the methylation of other proteins and the role in gene transcriptional activation,were summarized.Moreover,mutations of EZH2,responsible for an increased methyltransferase activity in cancer,were recapitulated.Finally,various drugs able to inhibit EZH2 with different mechanism were described,specifically underscoring the effects in several cancers,in order to clarify the role of EZH2 and understand if EZH2 blockade could be a new strategy for developing specific therapies or a way to increase sensitivity of cancer cells to standard therapies. | Irene Marchesi Luigi Bagella | 2016 | World Journal of Clinical Oncology2016，7，2： | 1 |
| 12 | Ezh2 reduces the ability ofHDAC1 -dependent pRb2/pl30 transcriptional repression of CyclinA显示文摘 | Tonini T Bagella L Dandrilli G | 2004 | Oncogene2004，23，49： | 1 |
| 13 | From GO to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway 显示文摘 | Sun A Bagella L Tutton S Romano G Giordano A | 2007 | J Cell Biochem2007，102，6： | 1 |
| 14 | Study of viral integration of HPV-16 in young patients with LSIL显示文摘 | Gallo G Bibbo M Bagella L | 2003 | J Clin Pathol2003，56，7： | 1 |
| 15 | Frequent loss of Rb2/p130 in human ovarian carcinoma 显示文摘 | Mascinllo V Bagella L | 2004 | Clin Cancer Res2004，10，9： | 1 |
| 16 | Physical interaction between pRb and cdk9/cyclin T2 complex 显示文摘 | Simone C Bagella L Bellan C Giordano A | 2002 | Oncogene2002，21，26： | 1 |
| 17 | Money laundering in a two-sector model:using theory for measurement 显示文摘 | ARGENTIERO A BAGELLA M BUSATO F | 2008 | European Journal of Law and Economics2008，26，3： | 1 |
| 18 | Cyclin E and chromosome instability in colorectal cancer cell lines显示文摘 | SIMONE C RESTA N BAGELLA L | | 0，，： | 1 |
| 19 | From G0 to S phase:a view of the roles played by the retinoblastoma(Rb)family members in the Rb-E2F pathway显示文摘 | Sun A Bagella L Tutton S | 2007 | J Cell Biochem2007，102，6： | 1 |
| 20 | Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors显示文摘 | Federico M Bagella L | | 0，，： | 1 |
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