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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 3 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 4 | 妊娠期糖尿病对大鼠雌性子代缺血再灌注后心脏收缩功能的影响及其机制显示文摘目的利用大鼠模型探讨妊娠期糖尿病(GDM)对雌性子代心脏功能的影响及潜在机制。方法雌性野生型SD大鼠在妊娠中期给予腹腔注射链脲佐菌素(35 mg/kg)建立GDM模型(GDM组),另设正常对照组。分娩后,雌性F1子代饲养至24周,期间测定随机血糖、血压和心率,进行葡萄糖耐量试验、胰岛素耐量试验。构建心脏离体缺血再灌注(I/R)模型,Western blotting检测心脏蛋白激酶B(Akt)、腺苷酸激活蛋白激酶(AMPK)和乙酰辅酶A羧化酶(ACC)信号通路。结果 GDM组雌性F1子代离体I/R后心脏收缩功能显著低于正常对照组(P=0.048 6);Western blotting显示离体I/R后GDM组雌性F1子代大鼠心脏AMPK和ACC磷酸化水平显著低于正常对照组(P=0.005 6)。结论 GDM可引起子代雌性大鼠对心脏I/R损伤不耐受,这可能与其心脏AMPK磷酸化对I/R刺激反应迟钝有关。 | 邹虹 姜小雪 王寒冰 袁雨 罗晓芳 谭彬 张华 Philip N Baker 童超 漆洪波 | 2016 | 上海交通大学学报(医学版)2016，36，2： | 5 |
| 5 | Effect of Vanadium Microalloying on the HAZ Microstructure and Properties of Low Carbon Steels显示文摘Four Steels,C-Mn-0.05V,C-Mn-0.11V,C-Mn-0.03Nb and C-Mn were subjected to heat treatment to simulate the microstructure of a coarse grained heat affected zone (CGHAZ) and an intercritically reheated coarse grained heat affected zone (ICCGHAZ).This involved reheating to 1350°C,rapid cooling (Δt 8/5 =24s) to room temperature and then reheating to either 750°C or 800°C.The toughness of the HAZs was assessed using both Charpy and CTOD tests.Microstructural features were characterised by optical,scanning` and transmission electron microscopy.Fractographic examinations of the Charpy and CTOD specimens were carried out to understand the micromechanism of fracture under different microstructural and test conditions.The CGHAZ toughness was similar for the steels except that Steel C-Mn-0.05V had a slightly lower ITT compared to the others.The toughness deteriorated in the ICCGHAZ for all the steels,again Steel C-Mn-0.05V had a superior toughness compared to the other three steels in both ICCGHAZ conditions.Raising the level of vanadium to 0.11% caused a decrease in ICCGHAZ toughness.Steel C-Mn-Nb exhibited a greater degradation of impact toughness after the intercritical cycles.The presence of M-A constituents was the dominant factor in determining the toughness of the ICCGHAZs.The size and area fraction of the M-A constituents were the smallest in Steel C-Mn-0.05V.Increasing vanadium level to 0.11% resulted in a greater area fraction of the M-A constituents,larger average and maximum sizes of M-A particles,and significantly more fields containing the M-A.The addition of 0.031% Nb produced the largest M-A particles and the greatest area fraction for the steels tested. | Milbourn D Baker T N | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 2 |
| 6 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 7 | In search of the Holy Grail-a further step in understanding metal hyperaccumulation? 显示文摘 | Baker A J M Whiting S N | 2002 | New Phytologist2002，155，： | 1 |
| 8 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantails J M Baker N R | 1989 | Biochim Biophys Acta1989，990，： | 1 |
| 9 | Direct drive wave energy converters 显示文摘 | BAKER N J MUELLER M A | 2001 | Rev Energ Ren : Power Engineering2001，，： | 1 |
| 10 | Commonality in the deter- minants of expected stock returns显示文摘 | Haugen R A Baker N L | 1996 | Journal of Fi- nancial Economics1996，41，3： | 1 |
| 11 | Applications of chlorophyll fluorescence can improve crop production strategies: an examination of future possibilities 显示文摘 | Baker N R Rosenqvist E | 2004 | Journal of Experimental Botany2004，55，403： | 1 |
| 12 | Accuracy of devices used for self-monitoring of blood glucose显示文摘 | Johnson R N Baker J R | 1998 | Ann Clin Biochem1998，35，1： | 1 |
| 13 | Influence of copper on the structural characteristics of carbon nanofibers produced from the cobaltcatalyzed decomposition of ethylene显示文摘 | CHAMBERS A RODRIGUEZ N M BAKER R T K | 1996 | J Mater Res1996，11，2： | 1 |
| 14 | The relationship between the quantum yield of photosynthetic electorn transport and quenching of chloorphyll fluorcscence显示文摘 | Genty B Brianais J M Baker N R | 1989 | Biochim Biophys Acta1989，199，： | 1 |
| 15 | Harpin, an elicitor of the hypersensitive response in tobacco caused by Erwinia amylovora, elicits active oxygen production in suspension cells 显示文摘 | BAKER C J ORLANDI E W MOCK N M | 1993 | Plant Physiology1993，102，： | 1 |
| 16 | The role of pain andfunction in determining patient satisfaction after total knee replace-ment:data from the National Joint Registry for England and Wales显示文摘 | Baker P N van der Meulen J H Lewsey J | 2007 | J Bone Joint Surg[Br]2007，89，7： | 1 |
| 17 | Surface engineering of Ti-6Al4V by nitridingand powder alloying using CW CO2 laser显示文摘 | Baker T N Selamat M S | | 0，，： | 1 |
| 18 | Effects of leaf shape and boundary layer thickness on photosynthesis in cotton(Gossypium birsutum)显示文摘 | Baker D N Myhre D L | 1969 | Physiologia Plantanma1969，22，5： | 1 |
| 19 | Leukoaraiosis predicts poor90-day outcome after acute large cerebral artery occlusion显示文摘 | Henninger N Lin E Baker SP | 2012 | Cerebrovasc Dis2012，33，6： | 1 |
| 20 | Land cover changes and their biogeophysical effects on climate显示文摘 | Rezaul Mahmood Roger A. Pielke Kenneth G. Hubbard Dev Niyogi Paul A. Dirmeyer Clive McAlpine Andrew M. Carleton Robert Hale Samuel Gameda Adriana Beltrán‐Przekurat Bruce Baker Richard McNider David R. Legates Marshall Shepherd Jinyang Du Peter D. Blanken | 2014 | Int J Climatol2014，，4： | 1 |
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