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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Effect of low dose dexmetomidine premedication on propofol consumption in geriatric end stage renal disease patients 显示文摘 | Ergenoglu P Akin S Bali C | 2015 | Rev Bras Anestesiol2015，65，5： | 1 |
| 3 | Displaced proximal humeral fractures :an Indian experience with locking plates 显示文摘 | Aggarwal S Bali K Dhillon MS e t al | 2010 | J Orthop Surg Res2010，23，5： | 1 |
| 4 | Ultrasound biomicroscopic assess- ment of angle parameters in patients with primary angle clo- sure glaucoma undergoing phacoemulsification显示文摘 | Dada T Mohan S Bali SJ | 2011 | Eur J Ophthal- mol2011，21，5： | 1 |
| 5 | Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage显示文摘 | Pascual M Balio P Alfonso-Loeches S | 2011 | Brain Behavior and Immunity2011，2011，25： | 1 |
| 6 | Demonstration of coal gas run molten carbonate fuel cell concept 显示文摘 | Mathur A Bali S Balakrishnan M | 1999 | INTERNATIONAL JOURNAL OF ENERGY RESEARCH1999，23，13： | 1 |
| 7 | Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration 显示文摘 | Balis F M Blaney S M Mccully C L | 2000 | Cancer Chemoth Pharm2000，45，3： | 1 |
| 8 | Histone deacetylase Inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B显示文摘 | Fuino L Bali P Wittmann S | 2003 | Mol Cancer Ther2003，2，10： | 1 |
| 9 | Palladium thin film deposition from liquid precursors on polymers by projected excimer beams显示文摘 | Kordás K Nánai L Bali L | 2000 | Applied surface Science2000，168，： | 1 |
| 10 | Response time and safety profile of pulsed oral methotrexate therapy in idiopathic retinal periphlebitis 显示文摘 | Bali T Saxena S Kumar D | 2005 | Eur J Ophthahnol2005，15，3： | 1 |
| 11 | Coronal frac- tures of the medial femoral condyle: a series of 6 cases and review of literature显示文摘 | DHILLON M S MOOTHA A K BALI K | 2012 | Musculoskeletal surgery2012，96，1： | 1 |
| 12 | Pediatric femoral neck fractures: Our 10 years of experience显示文摘 | Bali K Sudesh P Patel S | 2011 | Clin Orthop Surg2011，3，4： | 1 |
| 13 | Soil fertility and productivity of rice ( Oryza sativa ) - wheat ( Triticum aestivum ) cropping system in an inceptisol as influenced by integrated nutrient management 显示文摘 | Sharma M P Bali S V Gupta D K | 2001 | Indian Journal of Agricultural Sciences2001，71，： | 1 |
| 14 | Broad substrate specificity of ketoreductases derived from modular polyketide synthases显示文摘 | Bali S O'Hare H M Weissman K J | 2006 | Chem Bio Chem2006，7，3： | 1 |
| 15 | Role of genes linked to sporadic Alzheimer's disease risk in the production of 13-amyloid pep- tides显示文摘 | Bali J Gheinani A H Zurbriggen S | 2012 | Proc Nail Acad Sci USA2012，109，15： | 1 |
| 16 | Effect of statin therapy on remnant lipoprotein cholesterol levels in patients with combined hyperlipidemia显示文摘 | Stein DT Devaraj S Balis D | | 0，，12： | 1 |
| 17 | Soil fertility and productivity of rice (Oryza sativa) - wheat (Triticumaestivum) cropping system in an Inceptisol as influenced by integrated nutrient management 显示文摘 | Sharma M P Bali S V Gupta D K | 2001 | Indian Journal of Agronomy2001，71，2： | 1 |
| 18 | Androgen and estrogen receptor expression in the spinal segments of the genitofemoral nerve during testicular descent 显示文摘 | Nation T Buraundi S Balie A | 2011 | J Pediatr Surg2011，46，8： | 1 |
| 19 | An algorithm for fitting MMPP to IP traffic traces 显示文摘 | BALI S FROST V S | 2007 | Communications Letters IEEE2007，11，2： | 1 |
| 20 | Proprioception in anterior cruciate ligament deficient knees and its relevance in anterior cruciate ligament reconstruction显示文摘 | DHILLON M S BALI K PRABHAKAR S | | 0，，04： | 1 |
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