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| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | “VR+文化”背景下的中华古籍阅读与传统文化传播新路径研究显示文摘工业与信息化部提出要推进'VR+文化'重点产业的发展,推动现有的数字内容向虚拟现实内容移植。本文从'VR+文化'视角,探索利用虚拟现实技术推动现有古籍文本向虚拟现实内容转移的现实意义,归纳出'VR+古籍'推动古籍阅读与传统文化传播的6个显著改变,即阅读载体从二维向三维立体形式转变,阅读内容从文本形式向富媒体形式转变,读者人群从单一群体向多群体用户转变,传统文化知识获取路径从单一感官向多感官转变,阅读深度从对结构化古籍文本的理解向横纵联合的方向改变,读者对古籍内容的记忆由浅入深、加深加强。 | 张宁 Miguel Baptista Nunes 李俊炀 | 2019 | 图书馆建设2019，0，6： | 29 |
| 3 | 面向中华古籍阅读推广与文化传播的VR系统模型构建与实现显示文摘[目的/意义]旨在借助VR媒介技术,克服或弱化普通读者在古籍阅读中存在的古籍获取不便和古汉语理解、专业知识、特定文化背景知识、阅读动力不足的问题,促进古籍阅读推广与文化传播。[方法/过程]利用文献调研方法分析梳理认知科学和教育技术领域相关理论,提出VR古籍系统设计原则与模型,基于单个案例分析,设计、开发、测试系统原型,最后利用实验方法以问卷方式收集评估数据,验证设计原则、模型的有用性。[结果/结论]研究成果包括VR古籍系统设计原则、VR古籍系统理论模型、首例VR古籍系统应用原型、VR古籍系统使用理论,可为后续从事VR古籍系统研究与设计的科研人员和设计人员借鉴使用。 | 张宁 Miguel Baptista Nunes 李俊炀 张伟波 | 2021 | 图书情报工作2021，65，13： | 23 |
| 4 | Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer显示文摘AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. | Márcia Cristina Duarte Jucimara Colombo Andrea Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wornrath Ana Elizabete Silva | 2005 | World Journal of Gastroenterology2005，11，42： | 11 |
| 5 | GSTT1,GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population显示文摘MIM:To test the hypothesis that,in the Southeastern Brazilian population,the GSTT1,GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer.METHODS:We conducted a study on 100 cases of gastric cancer(GC),100 cases of chronic gastritis(CG),and 150 controls(C).Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR.CYP2E1/PsА genotyping was performed using a PCR-RFLP assay.RESULTS:No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups.However,a significant difference between CG and C was observde,due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group.The GSTT1 null genotype occurred more frequently in Negroid subjicts,and the GSTM1 null genotype was observed mainly in individuals with chronic gastritis infected with H pylori.CONCLUSION:Our findings indecate that there is no obvious relationship between the GSTT1,GSTM1 and CYP2E1 polymorphisms and gastric cancer. | Jucimara Colombo Ana Elizabete Silva Andréa Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wohnrath | 2004 | World Journal of Gastroenterology2004，10，9： | 11 |
| 6 | Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration显示文摘Studies have confirmed that bone marrow-derived mesenchymal stem cells(MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs(BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs(ADSCs) have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups: sham(only sciatic nerve exposed), Matrigel(MG; sciatic nerve injury + intravenous transplantation of MG vehicle), ADSCs(sciatic nerve injury + intravenous MG containing ADSCs), and BMSCs(sciatic nerve injury + intravenous MG containing BMSCs) groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury, increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios(axonal diameter/fiber diameter ratios) in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment. | Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 7 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 8 | 面向智能资源发现服务的城市记忆资源元数据方案构建显示文摘由于缺乏完善的分类体系和用于描述城市记忆资源的元数据方案,城市记忆资源并未得到有效组织,导致对资源发现服务的支撑较弱。高效的资源发现服务需要对资源的内容进行深度揭示,本研究以智能资源发现服务为导向,以现有的元数据标准为基础,结合城市记忆资源的内容特征和主题特征,提出了城市记忆资源的分类方法以及以内容描述为核心的城市记忆资源元数据方案。并基于该元数据方案开发了城市记忆资源标注系统,以广州记忆为例,对现有资源进行了著录。研究发现依照本元数据方案对城市记忆资源进行标注可以实现对海量无序城市记忆资源的有序组织,提供按资源主题分类、时代特征、记忆主体等的检索方式,有助于对智能资源发现服务的支撑。 | 罗婷予 Miguel Baptista Nunes | 2021 | 图书馆建设2021，，5： | 8 |
| 9 | Numerical Investigation of a Refractive Index SPR D-Type Optical Fiber Sensor Using COMSOL Multiphysics显示文摘 | D. F. SANTOS | 2013 | Photonic Sensors2013，3，1： | 8 |
| 10 | Peripheral nerve regeneration with conduits:use of vein tubes显示文摘Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit. | Rodrigo Guerra Sabongi Marcela Fernandes Joao Baptista Gomes dos Santos | 2015 | Neural Regeneration Research2015，10，4： | 7 |
| 11 | Engineering complex systems applied to risk management in the mining industry显示文摘Related to complexity, there is a wide diversity of concepts, ranging from ‘‘systemic' to ‘‘complex', implying a need for a unified terminology. Per different authors, the main drivers of complexity can be found in human behaviour and uncertainty. This complexity, structural or dynamic can be organizational, technological, or nested in their relationship. ISO international standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control an organization with regard to risk', when applied to economic sectors, industry, services, project, or activity, it requires the use of models or theories as guidelines. Therefore, as its basic elements comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possible to reality, must be operational within complex systems, as already demonstrated in different R&D environments. Risk management faces demanding challenges when approaching specific and endogenous needs, such as the mining sector. This paper presents a multivariable function analysis methodology approach based on complex system modelling and through real data corresponding to a risk management tool in the mining sector. | Domingues Maria S.Q. Baptista Adelina L.F. Diogo Miguel Tato | 2017 | International Journal of Mining Science and Technology2017，27，4： | 7 |
| 12 | Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses显示文摘Background:To identify biometric and implantable collamer lens(ICL)-related risk factors associated with suboptimal postoperative vault in eyes implanted with phakic ICL.Methods:This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ICL.Preoperatively,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the Pentacam.Anterior-segment optical coherence tomography(AS-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the vault.Eyes were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 and<1000μm)and high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault predictors.Results:MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLSE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00-1.01)and less myopic ICLSE(OR:1.22,CI:1.07-1.40)were risk factors for low vaults.Larger ICL size-ATA(OR:41.29,CI:10.57-161.22)and the 13.7mm ICL(OR:7.08,CI:3.16-15.89)were risk factors for high vaults,whereas less myopic ICLSE(OR:0.85,CI:0.76-0.95)and older age(OR:0.92,CI:0.88-0.98)were protective factors.Conclusion:High CLR and low ICLSE were the major risk factors in eyes presenting low vaults.In the opposite direction,ICL size-ATA was the major contributor for high vaults.This relationship was more critical in higher myopic ICLSE,younger eyes and when 13.7mm ICL were used.The findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high). | Santiago Cerpa Manito Angel Sánchez Trancón Oscar Torrado Sierra António Manuel Baptista Pedro Miguel Serra | 2021 | Eye and Vision2021，8，1： | 5 |
| 13 | Emerging concepts in liver graft preservation显示文摘The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion(MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures(hypothermia at 4 ℃, normothermia a t 3 7 ℃ and subnormothermia at 20 ℃- 2 5 ℃). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the 'state of the art' and future perspectives in static and dynamic liver graft preservation in order to improve graft viability. | Mohamed Bejaoui Eirini Pantazi Emma Folch-Puy Pedro M Baptista Agustín García-Gil René Adam Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，2： | 5 |
| 14 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 15 | Follow up of infection of chacma baboons with inoculum containing a and non-a genotypes of hepatitis B virus显示文摘AIM: To determine whether one genotype (A or non-A genotypes of HBV) predominated over the other during the course of HBV infection.METHODS: Four baboons were inoculated with HBV. DNA was extracted from serum obtained at monthly intervals postinoculation for 52 weeks and HBV DNA was amplified using primers specific for the core region containing an insert characteristic of genotype A (nt 2 354-2 359, numbering from the EcoRI site). The amplicons were cloned into PCRScriptTM and a minimum of 15 clones per time point were sequenced in both directions.RESULTS: Both genotypes persisted for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as shown at a 5 % level of testing.CONCLUSION: No conclusions concerning the dominance of either genotype or the natural progression or replication rates of HBV could be drawn because the pattern of the genotypes found may have been caused by sampling fluctuations at the time of DNA extraction and cloning as a result of the very low viral loads in the baboon sera. | Marina Baptista Anna Kramvis Saffie Jammeh Jocelyn Naicker Jacqueline S. Galpin Michael C. Kew | 2003 | World Journal of Gastroenterology2003，9，4： | 4 |
| 16 | 基于用户体验的数字记忆资源推荐系统界面设计研究显示文摘资源的累积使数字记忆平台面临的信息过载问题日益严重。智能推荐系统作为连接用户和资源的中介桥梁为解决这一问题提供了有效途径。业界和学术界一致认为推荐系统的界面设计对用户体验有着深远的影响。采用设计科学研究方法,旨在通过数字记忆资源推荐系统原型的开发和基于该系统的用户研究构建数字记忆资源推荐系统界面设计相关理论,发现在数字记忆情境下资源列表页面布局与用户感知决策效率显著相关,在推荐页面充分地展示资源的相关信息有助于提升用户对系统有用性的感知。另外,通过对问卷中开放性问题的质性分析,创新性地从微观、中观、宏观三个层面提出了用于指导数字记忆资源推荐系统界面设计的模型。 | 张洋 罗婷予 Miguel Baptista Nunes | 2022 | 图书馆建设2022，，4： | 4 |
| 17 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 18 | Obesity and weight loss could alter the properties of adipose stem cells?显示文摘The discovery that adipose tissue represents an interesting source of multipotent stem cells has led to many studies exploring the clinical potential of these cells in cell-based therapies. Recent advances in understanding the secretory capacity of adipose tissue and the role of adipokines in the development of obesity and associated disorders have added a new dimension to the study of adipose tissue biology in normal and diseased states. Subcutaneous adipose tissue forms the interface between the clinical application of regenerative medicine and the establishment of the pathological condition of obesity. These two facets of adipose tissue should be understood as potentially related phenomena. Because of the functional characteristics of adipose stem cells, these cells represent a fundamental tool for understanding how these two facets are interconnected and could be important for therapeutic applications. In fact, adipose tissue stem cells have multiple functions in obesity related to adipogenic, angiogenic and secretory capacities. In addition, we have also previously described a predominance of larger blood vessels and an adipogenic memory in the subcutaneous adipose tissue after massive weight loss subsequent to bariatric surgery(ex-obese patients). Understanding the reversibility of the behavior of adipose stem cells in obeses and in weight loss is relevant to both physiological studies and the potential use of these cells in regenerative medicine. | Leandra S Baptista Karina R Silva Radovan Borojevic | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 19 | 从用户视角理解智能推荐系统显示文摘随着推荐系统的广泛应用,探讨用户对推荐系统的理解,了解影响用户感知推荐系统的因素可以为推荐系统的评价以及开发设计提供理论参考。本研究为探索性研究,旨在验证研究的可行性以及研究问题的价值,本文采用定性研究方法,对4名普通用户进行焦点小组访谈,并借助NVivo 11软件通过内容分析法对访谈数据进行分析。研究发现用户感知到的推荐依据有用户偏好、用户行为以及业务需求。感知交互成本、多样性、覆盖率、感知有用性、环境背景兼容性、控制度、灵敏度、跨平台数据共享、推荐精度、新颖性和透明度是影响用户感知推荐系统的因素。 | 罗婷予 Miguel Baptista Nunes | 2019 | 数字图书馆论坛2019，0，10： | 3 |
| 20 | Ammonia Sensing System Based on Wavelength Modulation Spectroscopy显示文摘在近红外线的区域的一个察觉到的系统为基于波长调整光谱学 WMS 原则察觉到的氨被开发了。WMS 是为检测原子 / 分子的种类的一种相当敏感的技术,介绍它能在由使用光电信技术的在红外线附近的区域被使用的优点。在这种技术,激光波长和紧张被通过注射水流使用一个正弦波浪信号调制,它允许察觉带宽的移动到激光紧张噪音典型地更低的更高的频率。二个多传递房间基于有 160 厘米和 16 厘米光路径长度的空间光繁殖被使用,允许冗余性操作和技术确认。这个系统在 1512.21 nm 与排放波长使用了二极管激光,在的地方 NH < 潜水艇 class= “ a-plus-plus ” > 3 有一根强壮的吸收线。NH 的控制 < 潜水艇 class= “ a-plus-plus ” > 3 气体察觉到系统,以及获得,处理并且数据表示被执行。 | Duarte VIVEIROS Joao FERREIRA Susana O. SILVA Joana RIBEIRO Deolinda FLORES Jose L. SANTOS Orlando FRAZAO Jose M. BAPTISTA | 2015 | Photonic Sensors2015，5，2： | 3 |
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