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| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | Melt Infiltration Ability and Microstructural Evolution of Fe40Al/ TiC Composites System显示文摘Pressureless melt infiltration is an economic route f or preparation of high-density ceramic/melt composites. In this study, the Fe40 Al iron aluminide intermetallic, a low cost material of excellent oxidation and corrosion resistance, was used as binder for fabricating Fe40Al/TiC composites b y pressureless melt infiltration. The wetting ability of liquid Fe40Al in porous TiC pre-form was studied by in-situ monitoring the melting and infiltration p rocess. The infiltration ability was investigated by observing the distance of l iquid Fe40Al intrusion in porous TiC pre-forms at different infiltration temper atures and times by using optical microscope. Porous TiC per-forms with density of 60%~88%TD (theoretical density), prepared under pre-defined sintering temp e rature cycles, were used for fabricating Fe40Al/TiC composites in the range of 1 2%~40% metal content by volume. Almost full dense Fe40Al/TiC composites were su c cessfully fabricated by this technique. Liquid Fe40Al exhibited excellent infilt ration ability, the distance of complete intrusion of liquid Fe40Al in the TiC s intered pre-form with density of 88%TD was over 7 mm after 5 min at the inf iltration temperature of 1 450 ℃. Microstructural observation by SEM and TEM also showed that liquid Fe40Al filled the very narrow gaps among TiC particles, the interfaces of TiC particles and F e40Al plastic ligaments being metallurgical bonded. TEM revealed that high densi ty of dislocations formed in Fe40Al ligaments during solidification, which favor the mechanical properties. Ti decomposed from TiC particles and dissolved into Fe40Al during infiltration. According to the compositional analysis of TEM-EDS, the concentration of Ti in Fe40Al ranges at 1at%~4at% depending on composite f a bricating conditions and the distance from the measuring point to the closest Ti C particles. XRD analysis indicated that the composites were composed of two pha ses, the original TiC and Fe 0.4Al 0.6 intermetallic. No new phase formed during infiltration, but the lattice parameter of Fe 0.4Al 0.6 was expended due to the Ti in the solid solution. | F J Oliveira J L Baptista J M Vieira | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 3 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 4 | Milk - coagulating enzymes of tuna fish waste as a rennet substitute 显示文摘 | Tavares J F Baptista J A Marcone M F | 1997 | International Journal of Food Sciences and Nutrition1997，48，3： | 1 |
| 5 | Long-term exposure to high glucose increases the content of several exocy- totic proteins and of vesicular GABA transporter in cultured retinal neural cells显示文摘 | BAPTISTA F I CASTILHO A F GASPAR J M | 2015 | Nenrosci Lett2015，602，： | 1 |
| 6 | Ring fibre laser with interferometer based in long period grating for sensing applications 显示文摘 | Frazao O Correia C Baptista J M | 2008 | Optics Communications2008，281，22： | 1 |
| 7 | Light requirements in microalga| photobioreactors: an overview of biophotonic aspects 显示文摘 | Carvalho A P Silva S O Baptista J M | 2011 | Applied Microbiology and Biotechnology2011，89，5： | 1 |
| 8 | Substrate specificity, environmental degradation and disturbance structuring macroinvertebrate assemblages in neotropical streams 显示文摘 | Buss D F Baptista D F Nessimian J L | 2004 | Hydrobiologia2004，518，： | 1 |
| 9 | Mean-variance portfolio selection with ' at-risk 'constraints and discrete distributions 显示文摘 | Alexander G J Baptista A M Yan S | 2007 | Journal of Banking Finance2007，31，12： | 1 |
| 10 | Growth hormone (GH)replacement therapy in adult-onset GH deficiency:Effects on body composition in men and women in a double-blind,randomized,placebo-controlled trial显示文摘 | Hoffman AR Kuntze JE Baptista J | 2004 | J Clin Endocrinol Metab2004，89，5： | 1 |
| 11 | Role of niobium in magnesium titanate microwave dielectric ceramics显示文摘 | FERREIRA V M BAPTISTA J L | 1996 | J Am Chem Soc1996，79，6： | 1 |
| 12 | Sol-gel derived porous hydroxyapatite coatings显示文摘 | Baptista J L | 1998 | J Mater Sci Mater Med1998，9，3： | 1 |
| 13 | Improved modeling of side-chains in proteins with rotamer-based methods:a flexible rotamer model显示文摘 | Mendes J Baptista A M Carrondo M A | 1999 | Proteins1999，37，4： | 1 |
| 14 | Effect of carbon fibre reinforcement in the frictional behaviour of PEEK in a water lubricated environment显示文摘 | J Paulo Davim Nuno Marques A Monteiro Baptista | 2001 | Wear2001，251，： | 1 |
| 15 | Economic implications of using a mean -VaR model for portfolio selection:a comparison with mean-variance analysis显示文摘 | Baptista A M | 2002 | Journal of Economic Dynamics & Control2002，26，： | 1 |
| 16 | Cutting forces and wear analysis of Si3 N4 diamond coated tools in high speed machi- ning 显示文摘 | MARTINHO R P SILVA F J G BAPTISTA A P M | 2008 | Vacuum2008，82，12： | 1 |
| 17 | The preparation and characterization of hydroxyapatite coatings on Ti6Al4V alloy by a sol-gel method显示文摘 | Weng W Baptista J | 1999 | J Am Ceram Soc1999，82，： | 1 |
| 18 | A Comparison of VaR and CVaR Con- straints on Portfolio Selection with the Mean-variance Model 显示文摘 | Alexander G J Baptista A M | 2004 | Man- agement Science2004，50，9： | 1 |
| 19 | Multivariate near infrared spectroscopy models for predicting the iodine value, CFPP, kinematic viscosity at 40 ℃ and density at 15 ℃ of biodiesel显示文摘 | BAPTISTA P FELIZARDO P MENEZES J C | 2008 | Talanta2008，77，1： | 1 |
| 20 | Methodology for a rapid and simultaneous determination of total cysteine,homocysteine,cysteinylglycine and glutathione in plasma by isocratic RP HPLC显示文摘 | Ferin R Pavao ML Baptista J | 2012 | J Chromatogr B Analyt Technol Biomed Life Sci2012，911，： | 1 |
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