|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 3 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 4 | Stability analysis and improvement of structural index estimation in Euler deconvolution显示文摘 | Barbosa V C F Silva J B C Medeiros W E | 1999 | Geophysics1999，64，1： | 1 |
| 5 | Aggregation and clay dispersion of an oxisol treated with swine and poultry manures 显示文摘 | BARBOSA GMC OLIVEIRA J F MIYAZAWA M | 2015 | Soil & Tillage Research2015，146，： | 1 |
| 6 | Making Euler deconvolution applicable to small ground magnetic surveys显示文摘 | Valéria C F Barbosa Joao B C Silva Walter E Medeiros | 2000 | Journal of Applied Geophysics2000，43，1： | 1 |
| 7 | Polypropylene/Polystyrene Blends: In Situ Compatibilization by Friedel-Crafts Alkylation Reaction 显示文摘 | Diaz M F Barbosa S E Capiati N | 2004 | Journal of Polymer Science: Part B: Polymer Physics2004，42，： | 1 |
| 8 | Pharmacological and phytochemical studies of callus culture extracts from Alternanthera brasiliana 显示文摘 | Macedo A F Barbosa N C Esquibel M A | 1999 | Pharmazie1999，54，10： | 1 |
| 9 | Screening of yeasts for production of xylitol from D-xylose and some factors which affect xylitol yield in Candida guilliermondii显示文摘 | BARBOSA M F S MEDEIROS M B MANCILHA I M | 1988 | Journal of Industrial Microbiology1988，3，： | 1 |
| 10 | Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants显示文摘 | MONTENEGRO M F BARBOSA F JR SANDRIM V C | 2006 | Clin Chim Acta2006，367，： | 1 |
| 11 | Habitats and littoral zone fish community structure of two natural lakes in southeast Brazil 显示文摘 | VONO V BARBOSA F A | 2001 | Environmental Biology of Fishes2001，61，4： | 1 |
| 12 | Screening rice cultivars for higher efficiency of phosphorus absorption 显示文摘 | FAGERIA N K BARBOSA F M P | 1981 | Pesq Agropec Bras Brasilia1981，16，： | 1 |
| 13 | Utilization of sugar cane bagasse hemicellulosic hydrolyzate by Pichia stipitis for the production of ethanol显示文摘 | Roberto I C Lacis L S Barbosa M F S | 1991 | Proc Biochem1991，26，1： | 1 |
| 14 | Prospective multinational study of pertussis infection in hospitalized infants and their household contacts 显示文摘 | Kowalzik' F Barbosa A Femandes V | 2007 | Pediatr Infect Dis2007，26，3： | 1 |
| 15 | 3D Euler deconvolution : Theoretical basis for automatically selecting good solutions 显示文摘 | Silva J B C Barbosa V C F | 2003 | Geophysics2003，68，6： | 1 |
| 16 | A new method to obtain good anatomical slides of heterogeneous plant parts显示文摘 | BARBOSA A C F PACE M R WITOVISK L | 2010 | IAWA Journal2010，31，4： | 1 |
| 17 | The effect of lignin-related compounds on the growth and production of laccases by the ascomycete,Botryosphaeria sp显示文摘 | Dekker Robert F H Barbosa Aneli M Sargent Keith | 2002 | Enzyme and Microbial Technology2002，30，3： | 1 |
| 18 | Exercise training plays cardioprotection through the oxidative stress reduction in obese rats submitted to myocardial infarction显示文摘 | BARBOSA V A LUCIANO T F VITTO M F | 2012 | Int J Cardiol2012，157，3： | 1 |
| 19 | Complex-order dynamics in hexapod locomotion 显示文摘 | SILVA M F MACHADO J A BARBOSA R S | 2006 | Signal Processing2006，86，10： | 1 |
| 20 | Determination of trace element concentrations in tomato samples at different stages of maturation by ICP OES and ICP-MS following microwave-assisted digestion显示文摘 | BRESSY F C BRITO G B BARBOSA I S | 2013 | Microchemical Journal2013，109，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员