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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Interdepartmental Conflict in Organizational Buying:The Impact of the Organizational Context显示文摘 | Barclay D W | 1991 | Journal of Marketing Research1991，28，5： | 1 |
| 3 | Regulation of exocytosis by protein kinase C显示文摘 | MORGAN A BURGOYNE R D BARCLAY J W | 2005 | Biochem Soc Trans2005，33，6： | 1 |
| 4 | The Effects of Organizational Differences and Trust on the Effectiveness of Selling Partner Relationships 显示文摘 | Smith J B D W Barclay | 1997 | Journal of Marketing1997，61，1： | 1 |
| 5 | Wavefront expansion for nonlinear axial shear wave propagation 显示文摘 | BARCLAY D W | 1998 | International Journal of Non-linear Mechanics1998，33，2： | 1 |
| 6 | Shock front analysis for axial shear wave propagation in a hyperelastic incompressible solid 显示文摘 | BARCLAY D W | 1999 | International Journal of Non-linear Mechanics1999，133，14： | 1 |
| 7 | Regulation of exocytosis by protein kinase C 显示文摘 | Morgan A Burgoyne R D Barclay J W | 2005 | Biochem Soc Trans2005，33，： | 1 |
| 8 | Shock calculations for axially sym- metric shear wave propagation in a hyperelastic incom- pressible solid 显示文摘 | BARCLAY D W | 2004 | International Journal of Non-linear Mechanics2004，39，1： | 1 |
| 9 | The effects of organizational dif- ferences and trust on the effectiveness of selling partner re- lationships显示文摘 | Smith J B Barclay D W | 1997 | Journal of Marketing1997，，： | 1 |
| 10 | Business Strategic Orientation, Information Systems Strategic Orienta- tion, and Strategic Alignment 显示文摘 | CHAN Y E HUFF S L BARCLAY D W | 1997 | Information Systems Research1997，8，2： | 1 |
| 11 | The propagation and reflection of fi- nite amplitude cylindrically symmetric shear waves in a hyperelastic incompressible solid显示文摘 | BARCLAY D W | 2007 | Acta Meehaniea2007，193，12： | 1 |
| 12 | Regulation of exocytosis by protein kinase C显示文摘 | Morgan A L Burgoyne R D Barclay J W | 2005 | Biochemical Society Transactions2005，33，6： | 1 |
| 13 | Changes in lipid and protein during starvation and the moulcing cycle in the tiger prawn Penaeus esculencus 显示文摘 | Barclay M C Dah W Smith D M | 1983 | J Erp Mar Biol Ecol1983，68，： | 1 |
| 14 | The effects of organizational differences and trust on the effectiveness of selling partner relationships 显示文摘 | Smith B Barclay D W | 1997 | Journal of Marketing1997，61，1： | 1 |
| 15 | The effects of organizational differences and trust on the effectiveness of selling partner re- lationships显示文摘 | SMITH J B BARCLAY D W | 1997 | Journal of Marketing1997，61，1： | 1 |
| 16 | Regulation of ex- ocytosis by protein kinase C显示文摘 | Morgan A Burgoyne R D Barclay J W | 2005 | Biochem Soc Trans2005，33，6： | 1 |
| 17 | Interdepartmental conflict in organizational buying:the impact of the organizational context显示文摘 | Barclay D W | 1991 | Journal of Marketing Research1991，28，5： | 1 |
| 18 | Changes in lipid and protein during starvation and the moulting cycle in the tiger prawn, Penaeus esculentus(Haswell) 显示文摘 | Barclay M C Dall W Smith D M | 1983 | J Exp Mar Biol Eco11983，68，3： | 1 |
| 19 | The effects of organizational differences and tust on the effectiveness of selling partner relationships显示文摘 | SMITH J B BARCLAY D W | 1997 | Journal of Economic Behavior & Organization1997，，34： | 1 |
| 20 | The Effects of Organizational Differences and Trust on the Effectiveness of Selling Partner Relationships显示文摘 | SMITH J B BARCLAY D W | 1997 | Journal of Marketing1997，61，1： | 1 |
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