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293篇 您的检索式:作者名="BARCLAY M"
    题名 作者 年代 出处 被引量
1NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley 2011World Journal of Gastroenterology2011,17,23:2
2Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysac-charide complex from Bacteroides species 显示文摘Delahooke D M Barclay G R Poxton 1 R 1995Infect Immun1995,63,3:1
3The Maturity Structure of Corporate Debt 显示文摘Barclay M J Smith C W 1995The Journal of Finance1995,50,2:1
4Selecting offshore LNG processes显示文摘Barclay M Denton N 2005LNG Journal2005,,:1
5Morphometric evaluation of the contractile apparatus in primary cultures of rabbit cardiac myocytes 显示文摘Decker ML Behnke- Barclay M Cook MG 1991Circ Res1991,69,1:1
6Private Benefits from Control of Public Corporations显示文摘Barclay M J Holdemess C G 1989Journal of Financial Economics1989,,25:1
7The maturity structure of corporate debt显示文摘Barclay M Smith C 1995Journal of Finance1995,50,2:1
8Stealth trading and volatility: which trades move prices 显示文摘M J Barclay J Warner 1993Journal of Financial Economics1993,34,3:1
9The Maturity Structure of Corporate Debt显示文摘Barclay M J C W Smith Jr 1995Journal of Finance1995,50,2:1
10Microbial decolourisation of a reactive azo dye under anaerobic conditions显示文摘Carliell C M Barclay S J Naidoo N 1995Water SA1995,21,1:1
11On the antioxidantmechanism of curcumin:classic methods are needed to determine antioxidantmechanism and activity显示文摘Vinqvist M R Barclay L R 2000O rg Lett2000,2,18:1
12Private benefits from control of public corporations 显示文摘Barclay M Holderness C G 1989Journal of Financial Economics1989,,25:1
13The Maturity Structure of Corporate Debt 显示文摘Barclay M J Smith C W 1995Journal of Finance1995,50,:1
14Private Benefits from Control of Public Corporations显示文摘BARCLAY M HOLDERNESS C 1989Journal of Financial Economics1989,25,2:1
15Localisation of the MRC OX-2glycoprotein on the surfaces of neurones显示文摘Webb M Barclay AN 1984J Neurochem1984,43,:1
16Private benefits from control of public corporations 显示文摘Barclay M J Holderness C G 1989Journal of Financial Economics1989,25,2:1
17Private Placements and Managerial Entrenchment 显示文摘BARCLAY M J HOLDERNESS C G SHEEHAN D P 2007Journal of Corporate Finance2007,13,9:1
18‘ No more strangers' : Investigating the experiences of women, midwives and others during the establishment of a new model of maternity care for remote dwelling aboriginal women in northern Australia 显示文摘Josif C M Barclay L Kruske S 2014Midwifery2014,30,3:1
19Media Effects on Anlioxidant Activitics Of Phenols and Calechols显示文摘Barclay L R Edwards C E Vinqvist M R 1999Journal of the American Chemical Society1999,121,:1
20Stealth trading and volatility: Which trades move prices? 显示文摘Barclay M J Warner J B 1993Journal of Financial Economics1993,34,3:1
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