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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Optimizing erythropoi- etintherapy in Hemodialysis patients 显示文摘 | Richardson D Bartlett C Will EJ | 2001 | Am J Kidney Dis2001，38，1： | 1 |
| 5 | Spinning magnets and Jehle's model of the electron显示文摘 | Bartlett D F Monroy J Reeves J | 1977 | Phys Rev D1977，16，： | 1 |
| 6 | Dental erosion, gastro-oesophageal reflux disease and sallva: how are they related 显示文摘 | Moazzez R Bartlett D Anggiansah A | 2004 | J Dent2004，32，6： | 1 |
| 7 | Kinetics of dolomitization显示文摘 | Sibley D F Dedoes R E Bartlett T R | 1987 | Geology1987，15，： | 1 |
| 8 | Application of machine learning in the fault diagnostics of air handling units显示文摘 | Najafi M Auslander D M Bartlett P L | 2012 | Applied Energy2012，96，： | 1 |
| 9 | The insomnia patient perspective, a narrative review 显示文摘 | Cheung JM Bartlett D J Armour CL | 2013 | Behav Sleep Med2013，11，5： | 1 |
| 10 | The Strobilurin Fungicides 显示文摘 | BARTLETT D W CLOUGH J M GODWIN J R | 2002 | Pest Manag Sci2002，58，： | 1 |
| 11 | Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging显示文摘 | BARTLETT D W SU H HILDEBRANDT I J | 2007 | Proc Natl Acad Sci USA2007，104，15： | 1 |
| 12 | Fault diagnostics of dynamic system operation using a fault tree based method显示文摘 | HURDLE E E BARTLETT L M ANDREWS J D | 2009 | Reliability Engineering and System Safety2009，94，9： | 1 |
| 13 | Review the strobilurin fungicides 显示文摘 | Bartlett D W Clough J M Godwin J R | 2002 | Pest Manag Sci2002，58，7： | 1 |
| 14 | Pressure effects on in vivo microbial processes显示文摘 | BARTLETT D H | 2002 | Biochemical et Biophysical Acta2002，1995，： | 1 |
| 15 | Fault diagnostics of dynamic system operation using a fault tree based method显示文摘 | HURDLE E E BARTLETT L M ANDREWS J D | 2009 | Reliability Engineering&System Safety2009，94，9： | 1 |
| 16 | Solute accumulation in the deep-sea bacterium Photobacterium profundum显示文摘 | Martin D D Bartlett D H Roberts M F | 2002 | Extremophiles2002，6，： | 1 |
| 17 | Histologic grading of pancress acute allograft rejection in percutaneous needle biopsies 显示文摘 | Drachenherg C Klassen D Bartlett S | 1996 | Transplant Proc1996，28，1： | 1 |
| 18 | Mesotrione:a new selective herbicide for use in maize显示文摘 | Mitchell G Bartlett D W Fraser T E M | | 0，，： | 1 |
| 19 | Effect of prenataldiagnosis onoutcomes in D-transposition of the greatarteries 显示文摘 | Bartlett JM Wypij D Bellinger DC | 2004 | Pediatrics2004，113，4： | 1 |
| 20 | An ordering heuristic to develop the binary decision diagram based on structural Importance显示文摘 | Bartlett L M Andrews J D | 2001 | Reliability Engineering and System Safety2001，72，： | 1 |
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