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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Generation of 60-GHz MB-OFDM Signal-Over-Fiber by Up-Conversion Using Cascaded External Modulators 显示文摘 | GIANG H N BEATRICE C YANNIS L G | 2009 | Journal of Lightwave Technology2009，27，912： | 1 |
| 3 | Antigenic and genetic char- acteristics of swine - origin 2009 A( H1N1 ) influenza viruses cir- culating in humans 显示文摘 | Garten R J Davis C T Russell C A Shu B Lindstrom S Balish A Sessions W M Xu X Skepner E Deyde V Okomo - Adhi- ambo M Gubareva L Barnes J Smith C B Emery S L Hillman M J Rivailler P Smagala J de Graaf M Burke D F Fouchier R A Pappas E Alpuche - Aranda C M Lopez - Gatell H Ohvera H Lopez I Myers C A Faix D Blair P J Yu C Keene K M Dotson P D Jr Boxrud D Sambol A R Abid S H St George K Bannerman T Moore A L Stringer D J Blevins P Demmler - Harrison G J Ginsberg M Kriner P Waterman S Smole S Guevara H F Belongia E A Clark P A Beatrice S T Donis R Katz J Finelli L Bridges C B Shaw M Jernigan D B Uyeki T M Smith D J Klimov A I Cox N J | 2009 | Science2009，325，5937： | 1 |
| 4 | Activation of ADP receptors and platelet function显示文摘 | CHRISTIAN G BEATRICE H CATHERINE L | 1997 | Thromb Hae Most1997，78，1： | 1 |
| 5 | Multi-Server Support for Large Scale Distributed Virtual Scenes 显示文摘 | Beatrice N Lau R W H Antonio S | 2005 | IEEE Transac tions on Multimedia2005，7，6： | 1 |
| 6 | Late ovarian relapse of TEL/AML1 positive ALL confirming that TEL deletion is a secondary event in leukemogenesis 显示文摘 | Beatrice L Catherine H Virginie G | 2005 | Leukemia Research2005，29，9： | 1 |
| 7 | A novel phase inversionbased process for the preparation of lipid nanocarriers 显示文摘 | Beatrice H Patrick S Brigitte P | 2002 | Pharm Res2002，19，6： | 1 |
| 8 | Differential sensitivities of severe acute respiratory syndrome(SARS)coronavirus spike polypeptied enzymelinked immunosorbent assay (ELISA) and SARS coronavirus nucleocapsid protein ELISA for serodiagnosis of SARS coronavirus pneumonia显示文摘 | Susanna K P L Beatrice H L | 2005 | J Clinical Microbiol2005，43，7： | 1 |
| 9 | Dynamic vehicle routing using genetic algorithm显示文摘 | FRANKLIN T H BEATRICE M OMBUKI-BERMA N | 2007 | Applied Intelligence2007，27，1： | 1 |
| 10 | Water-in-CO2 microemulsions studied by small-angle neutron scattering 显示文摘 | JULIAN E BEATRICE M H C STEYTLER D C | 1997 | Langmuir1997，13，26： | 1 |
| 11 | Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men显示文摘 | Paul M Ridker Charles H Hennekens Beatrice Roitman-Johnson Meir J Stampfer Jean Allen | 1998 | The Lancet1998，，9096： | 1 |
| 12 | 查看详情显示文摘 | Sulpice E Ding S Muscatelli-Groux B Beatrice M G Mathieu B Zhong C H Jean P Gerard T Tatyana M R | | 0，，09： | 1 |
| 13 | Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer显示文摘前列腺癌症(PCa ) 在发达国家仍然是死亡的一个主要原因。因为没有临床的干预克服电阻到雄激素脱离治疗,阉割电阻和变形疾病的管理大部分仍然是 untreatable。转移是肿瘤房间在失去房间房间接触的一个 multistep 过程,从主要肿瘤的外出, intravasate,幸存砍在 vasculature 和使从脉管中溢出以内强调进纸巾开拓殖民地于宫外的地点。肿瘤房间重建在象胚胎的开发,白血球 trafficking 并且创伤愈合那样的 nonneoplastic 过程期间采用的迁移的行为。当间充质的活动性是传播的一个确定的范例时,替换物, ‘ amoeboid’显型逐渐地作为相关被欣赏到人的癌症。这里,我们讨论位于显型下面的特征和小径,并且加亮我们细胞骨架管理者 DIAPH3 管理的调查结果间充质似变形虫的转变。我们也描述我们导出肿瘤的 microvesicles 的一个新类的鉴定,大 oncosomes,在前列腺和另外的癌症由似变形虫的房间并且与潜在的临床的用途生产了。 | Samantha Morley Martin H Hager Sara G Poilan Beatrice Knudsen Dolores Di Vizio Michael R Freeman | 2014 | Asian Journal of Andrology2014，16，4： | 1 |
| 14 | New method for membrane constuction on ePTFE vascular grafts: effect on surface morphology and platelet adhesion显示文摘 | Beatrice H | 1997 | Journal of Applied Polymer Science1997，63，11： | 1 |
| 15 | Multi-objective genetic algorithms for vehicle routing problem with time windows显示文摘 | Beatrice O Brian J R Franklin H | 2006 | Applied Intelligence2006，24，1： | 1 |
| 16 | Profiling primary protease specificity by peptide synthesis on a solid support显示文摘 | Beatrice A Doeze R H P Maltman B A | 2004 | Angew Chem Int Ed Engl2004，43，24： | 1 |
| 17 | Alternative foodpreservation technologies:efficacy and mechanisms显示文摘 | Beatrice H Lado Ahmod E Yousef | 2002 | Microbes and Infection2002，4，： | 1 |
| 18 | Plasma concentration of soluble intercellular adhezion molecule-1 and risks of future myocardial infarction in apparently healthy men显示文摘 | Paul M MCharles H Beatrice RJ | 1998 | LANCET1998，351，： | 1 |
| 19 | Reversed-phase high-performance liquid chromatographic determination of enoxacin and 4-oxo-enoxacin in human plasma and prostatic tissue application to a pharmacokinetic study显示文摘 | Michel A Pierre C | 1998 | Chromatogr A1998，812，1： | 1 |
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