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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Atopic eczema treatment now and in the future:Targeting the skin barrier and key immune mechanisms in human skin显示文摘The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects up to 20% of children and 3% of adults worldwide, manifesting as red itchy patches of skin with varying severity. This review aims to investigate the leaky skin barrier and immune mechanisms from the perspective of potential novel treatments. The complexity of atopic eczema as a disease is what makes it difficult to treat. Genome-wide association studies have highlighted possible genetic variations associated with atopic eczema, however in some cases, individuals develop the disease without these genetic risk factors. Loss of function mutations in the filaggrin gene are one of these associations and this is plausible due to its key role in barrier function. The Th2 immune response is the link with regards to the immune mechanisms as atopic inflammation often occurs through increased levels of interleukin(IL)-4 and IL-13. Eczematous inflammation also creates susceptibility to colonisation and damage by bacteria such as Staphylococcus aureus. Potential novel treatments are becoming ever more specific, offering the hope of fewer side effects and better disease control. The best new treatments highlighted in this review target the immune response with human beta defensin 2, phosphodiesterase-4 inhibitors and monoclonal antibodies all showing promise. | David C Bell Sara J Brown | 2017 | World Journal of Dermatology2017，6，3： | 5 |
| 3 | Requirement of the auxin polar transport system in early stages of Arabidopsis floral bud formation显示文摘 | OKADA K UEADA J KOMAKI M K BELL C J SHIMURA Y | 1991 | Plant Cell1991，3，7： | 1 |
| 4 | Patterns of expression of Bax, Bcl-2 and Bcl-x(L) in the implantation site in rat during pregnancy 显示文摘 | CORREIA-DA-SILV BELL S C PRINGLE J H | 2005 | Placenta2005，26，10： | 1 |
| 5 | The influence of design, materials and kinematics on the in vitro wear of total knee replacements 显示文摘 | McEwen HM Barnett PI Bell C J | 2005 | J Biomech2005，38，： | 1 |
| 6 | ACR guidance document forsafe MR practices : 2007显示文摘 | Kanal E Barkovich A J Bell C | 2007 | Am J Roentgenol2007，188，6： | 1 |
| 7 | Peanut leaf photosynthetic activity in cool field environments显示文摘 | Bell M J Gillespie T J Roy R C | 1994 | Crop Science1994，34，4： | 1 |
| 8 | Dietary fiber intakes and insulin requirement in pregnant women with type I diabetes 显示文摘 | KALKWART H J BELL R C KHOURY J C | 2001 | J Am Diet Assoc2001，101，3： | 1 |
| 9 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Application Microbiology1967，15，： | 1 |
| 10 | 显示文摘 | Hammond P J Bell A P Hall C D | 1983 | J Chem Soc Perkin Trans 11983，，4： | 1 |
| 11 | Autooxidation of oil emulsions during the Artemia enrichment process显示文摘 | Mcevoy L A Navarro J C Bell J G | 1995 | Aquaculture1995，134，12： | 1 |
| 12 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 13 | Leucine-rich repeats and pathogen recognition in Toll-like receptors 显示文摘 | Bell J K Mullen G E Leifer C A | 2003 | Trends Immunol2003，24，： | 1 |
| 14 | Assignment of 30 microsatellite loci to- the linkage map of Arabidopsis 显示文摘 | Bell C J Ecken J R | 1994 | Genomics1994，19，： | 1 |
| 15 | In-plane vibration of annular rings显示文摘 | Ambati G Bell J F W Sharp J C K | 1976 | Journal of Sound and Vibration1976，47，： | 1 |
| 16 | Isolation of thermophiles from brood leaf tobacco and effect of pure ulture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Ape Microbio1967，，15： | 1 |
| 17 | Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis 显示文摘 | Gregorian C Nakashima J Le Belle J | 2009 | J Neurosci2009，29，6： | 1 |
| 18 | Leucine-rich repeats and pathogen recognition in Toll-like receptors显示文摘 | Bell J K Mullen G E Leifer C A | 2003 | Trends Immunol2003，24，： | 1 |
| 19 | Behaviour of some trace elements in alluvial sediments, Zagerb water-well field atea,Croatia 显示文摘 | Vertacnik R D Redely C Bell J C | 1995 | Water Research1995，29，23： | 1 |
| 20 | Polymorphic microsatellite loci in the European rabbit (Oryctolagus cuniculus)are also amplified显示文摘 | Surridge A K Bell D J Rico C | 1997 | Anim Genets1997，28，： | 1 |
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