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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 3 | Green Infrastructure: Smart Conservation for the 21st Century显示文摘 | Benedict M A Mcmahon E T | 2002 | Renewable Resources Journal2002，，3： | 1 |
| 4 | The effects of perceived interdependence on dealer attitudes 显示文摘 | Kumar N Scheer L K Steenkamp Jan Benedict E M | 1995 | Journal of Marketing Research1995，32，3： | 1 |
| 5 | Rotation-vibration spec- tra of deuterated water vapor显示文摘 | Benedict W S Gailar N Plyler E K | 1956 | The Journal of Chemical Physics1956，24，6： | 1 |
| 6 | Childhood obesity affects fine motor skill performance under different postural constraints 显示文摘 | D'HONDT E BENEDICTE D I1SE DB | 2008 | Neurosci Letters2008，440，1： | 1 |
| 7 | A meta - analysis of satisfaction in marketing channel relationships 显示文摘 | INGE GEYSKENS JAN - BENEDICT E M STEENKAMP NIR- MALYA KUMAR | 1999 | Journal of Marketing Research1999，，36： | 1 |
| 8 | First-principles calculations of solid and liquid aluminum optical absorption spectra near the melting curve: ambient and high-pressure results 显示文摘 | Ogitsu T Benedict L X Schwegler E | 2009 | Phys Rev B2009，80，21： | 1 |
| 9 | Regulation of the transcription and replication cycle of human cytomegalovirus is insensitive to genetic elimination of the cognate NF- kappaB binding sites in the enhancer显示文摘 | Gustems M Borst E Benedict CA | 2006 | J Virol2006，80，19： | 1 |
| 10 | Expression and segregation of genes Cry1A insecticidal proteins in cotton 显示文摘 | SACHS E S BENEDICT J H STELLY D M et at | 1998 | Crop Sci1998，38，： | 1 |
| 11 | Green infrastructure : smart conservation for the 21 st century 显示文摘 | Benedict M A MeMahon E T | 2002 | Renewable Resources Journal2002，20，3： | 1 |
| 12 | Pensions and wages:An hedonic price theory approach 显示文摘 | MONTGOMERY E SHAW K BENEDICT M E | 1992 | International Economic Review1992，33，1： | 1 |
| 13 | Pyramiding CrylA (b) insecticidal protein and terpenoids in cotton to resist tobacco budworm (Lepidoptera: Noctuidae)显示文摘 | Sachs E S Benedict J H Taylor J F | 1996 | Environmental Entomology1996，25，6： | 1 |
| 14 | Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas显示文摘 | Benedict Yan Malcolm Lim Lihan Zhou Chik Hong Kuick May Ying Leong Kol Jia Yong LeLe Aung Manuel Salto-Tellez Kenneth T E Chang | 2013 | Journal of Clinical Pathology2013，，11： | 1 |
| 15 | Green Infrastructure: Smart Conservation for the 21 Century显示文摘 | Benedict M A McMahon E T | 2002 | Renewable Resources Journal2002，，3： | 1 |
| 16 | Pyramiding CrylA (b) insecticidal protein and terpenoids in cotton to resist tobacco budworm 显示文摘 | Sachs E S Benedict J H | 1998 | Environmental Entomology1998，25，6： | 1 |
| 17 | Field performance of cottons expressing transgenic Cry IA insect icidal proteins for resistance to Heliothis virescens and Heliocover pazea显示文摘 | Benedict J H Sachs E S Altman D W | 1996 | Eco Ent1996，89，1： | 1 |
| 18 | Plastic Hinge Approach to Vehicle Crash Simulation显示文摘 | Nikravesh P E Chung I S Benedict R L | 1983 | Computers & 8truc tures1983，16，1： | 1 |
| 19 | Delay and Distortion: Tacit Influences on Performance Appraisal Effectiveness 显示文摘 | BENEDICT M LEVINE E | 1988 | Journal of Applied Psychology1988，73，3： | 1 |
| 20 | Fiber development of ligon lintless-2 mutant of cotton显示文摘 | RUSSELL J KOHEL NARBUTH E V BENEDICT C R | 1992 | Crop Science1992，32，： | 1 |
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