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1Evaluation of antiviral activities of Houttuynia cordata Thunb.extract,quercetin,quercetrin and cinanserin on murine coronavirus and dengue virus infection显示文摘Objective:To evaluate the in vitro activities of the ethyl acetate(EA) fraction of Houttuynia cordata(H.cordata) Thunb.(Saururaceae) and three of its constituent flavonoids(quercetin.quercitrin and rutin) against murine coronavirus and dengue virus(DENV).Methods:The antiviral activities of various concentrations of the EA fraction of H.cordata and flavonoids were assessed using virus neutralization tests against mouse hepatitis virus(MHV) and DENV type 2(DENV-2).Cinanserin hydrochloride was also tested against MHV.The EA fraction of H.cordata was tested for acute oral toxicity in C57BL/6 mice.Results:The EA fraction of H.cordata inhibited viral infectivity up to 6 d.Cinanserin hydrochloride was able to inhibit MHV for only 2 d.The 50%inhibitory concentrations(IC_(50)) of the EA fraction of H.cordata added before the viral adsorption stage were 0.98 μg/mL for MHV and 7.50 μg/mL for DENV-2with absence of cytotoxicity.The mice fed with the EA fraction up to 2 000 mg/kg did not induce any signs of acute toxicity,with normal histological features of major organs.Certain flavonoids exhibited comparatively weaker antiviral activity,notably quercetin which could inhibit both MHV and DENV-2.This was followed by quercitrin which could inhibit DENV-2but not MHV,whereas rutin did not exert any inhibitory effect on either virus.When quercetin was combined with quercitrin,enhancement of anti-DENV-2 activity and reduced cytotoxicity were observed.However,the synergistic efficacy of the flavonoid combination was still less than that of the EA fraction.Conclusions:The compounds in H.cordata contribute to the superior antiviral efficacy of the EA fraction which lacked cytotoxicity in vitro and acute toxicity in vim.H.cordata has much potential for the development of antiviral agents against coronavirus and dengue infections.K.H.Chiow M.C.Phoon Thomas Putti Benny K.H.Tan Vincent T.Chow 2016Asian Pacific Journal of Tropical Medicine2016,9,1:38
2低成本吸附剂稻壳灰对Cr(Ⅵ)去除机制的谱学表征显示文摘以低成本稻壳灰作为吸附剂,使用FTIR,SEM,XPS,XRD,XRF等分析手段,研究稻壳灰对Cr(Ⅵ)的去除机制。FTIR研究表明酰胺Ⅱ带,Si—O—Si,O—Si—O等在Cr(Ⅵ)去除过程中有一定贡献。由SEM图片清晰可见:吸附Cr(Ⅵ)后,稻壳灰表面分布有众多的光亮沉积物。XPS图谱证明:稻壳灰的主要组成元素为C,N,O,P和Si;C元素的存在状态以醛酮类为主,含C官能团与Cr(Ⅵ)发生了配位反应;N元素以—NH2形态为主,Cr(Ⅵ)可能以静电作用与含N基团结合,并以物理吸附为主;Si的存在以Si—O为主,含Si官能团可能与Cr(Ⅵ)发生了配位反应。XRD分析结果表明:谱图中出现的峰是典型的SiO2特征峰;稻壳灰的结晶度增加,表明稻壳灰与Cr(Ⅵ)形成了具有晶体结构的金属化合物。XRF研究发现,K,Na,Mg和Ca的元素含量在吸附前后有所变化,另有两种新元素出现,这说明吸附过程存在离子交换机制。所有这些皆表明:各种官能团在Cr(Ⅵ)去除过程中的角色各不相同,无机微沉淀机制、氧化还原机制、表面络合机制、离子交换机制等是稻壳灰去除Cr(Ⅵ)的主要途径。这可以为吸附技术的实际应用提供理论支持。范春辉 张颖超 张颖 韩雪 Benny Chefetz 2010光谱学与光谱分析2010,30,10:13
3Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data.Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 2021Journal of Geodesy and Geoinformation Science2021,4,1:13
4The Arabidopsis DSO/ABCG 11 Transporter Affects Cutin Metabolism in Reproductive Organs and Suberin in Roots显示文摘除了它在对压力条件的保护的意义,表皮的盖子为在天线植物机关上形成的多样的表面结构的合适的开发是必要的。这层主要由一个角质矩阵组成,与表皮的蜡嵌入并且覆盖。在表皮的房间,角质和蜡跟随他们的生合成被建议被象 DSO/ABCG11 那样的 ABCG 类型 transporters 越过血浆膜出口到房间墙并且进一步到细胞外的矩阵。这里, DSO/ABCG11 功能的另外的方面被调查,主要在繁殖机关,它没在以前的报告被揭示。这被显示了相对微妙的词法、化学的显型的一根转基因的 DSO/ABCG11 silenced 线(dso-4 ) 的产生便于。这些包括的改变的花瓣和 silique 形态学,种子的熔化,和在在花和 siliques 的角质单体的层次的变化。dso-4 显型在胚胎外皮以及在发展中的种子的内乳纸巾对应于强壮的 DSO/ABCG11 基因表示。而且, DSO/ABCG11 蛋白质在胚胎 protoderm 显示了极的本地化。dso-4 异种叶子和茎的 Transcriptome 分析证明那项减少的 DSO/ABCG11 活动压制了很多联系表皮的基因的表示,暗示从血浆膜的表皮的类脂化合物的出口是在表皮新陈代谢的限制率的步。令人惊讶地, dso-4 的根软木脂作文被改变,以及二软木脂 biosynthetic 基因的根表示。一起拿,这研究在繁殖机关和根开发提供新卓见进角质和软木脂新陈代谢和他们的角色。David Panikashvili Jian Xin Shi Samuel Bocobza Rochus Benni Franke Lukas Schreiber Asaph Aharoni 2010Molecular Plant2010,3,3:12
5红外光谱法研究低温焚烧稻壳灰对Cr(Ⅵ)的吸附机理显示文摘采用Boehm滴定法量化了低温焚烧稻壳灰表面官能团,考察了溶液初始pH值和温度对吸附效能的影响,借助动力学方程和吸附等温线,研究了稻壳灰对Cr(Ⅵ)的吸附性能,利用红外图谱、扫描电镜表征了稻壳灰的表面形貌和吸附机理。结果表明:在pH值为5时,稻壳灰对Cr(Ⅵ)取得最优去除效果,吸附前后溶液pH值变化很小。稻壳灰对Cr(Ⅵ)有较强的去除能力,对于20 mg.L-1的Cr(Ⅵ)溶液,最高去除率能达到95%左右,达到《污水综合排放标准GB8978—1996》1~2级标准。吸附过程能更好地符合准二级反应动力学方程和Langmuir等温线方程,饱和吸附容量可达3.277 6 mg.g-1。红外光谱表明酰胺Ⅱ带、Si—O—Si、O—Si—O等在Cr(Ⅵ)吸附过程中可能有重要贡献。扫描电镜图片表明吸附Cr(Ⅵ)后,稻壳灰表面分布有众多的光亮沉积物,有条带状或不规则点斑出现,推测无机微沉淀和氧化还原机理在吸附过程中起重要作用。稻壳灰是一种价格低廉、有应用潜力的高效吸附剂,可以用于水体重金属污染的治理修复。范春辉 张颖 张颖超 李晶 Benny Chefetz 2010光谱学与光谱分析2010,30,9:11
6血管源性脑白质病变与眼底血管网络几何学参数的相关性分析显示文摘目的利用计算机辅助的全自动眼底照相分析技术,研究血管源性脑白质病变严重程度与眼底血管网络参数的相关性。方法纳入2015年3—10月于中山大学附属第一医院神经科住院的能完成颅脑MR和坐位眼底照相的脑小血管病患者106例.分别对其颅脑MR显示的脑室旁脑白质病变及深部脑白质病变程度进行Fazekas评分,按照评分将患者分别分为轻度及中重度病变组:比较不同部位不同病变程度患者的基线临床资料和眼底血管网络参数。结果依照脑室旁脑白质病变严重程度分组分析,校正基线信息后行Logistic回归分析显示.脑小动脉不对称性指数(OR=1.71,95%CI 1.02-2.88.P<0.05)的减小与中重度脑室旁脑白质病变风险增加有关。依照深部脑白质病变严重程度分析,校正基线信息后行Logistic冋归分析显示,视网膜中央动脉直径等效值(OR=5.19,95%CI 1.06-25.44,P<0.05)、脑小动脉不对称指数(OR=2.96,95%CI 1.42-6.17,P<0.05)、脑小静脉不对称指数(OR=2.99,95%CI 1.48-6.02,P<0.05)的减小和视网膜中央静脉直径等效值(OR=0.14,95%CI 0.03-0.67,P<0.05)的增加与中重度深部脑白质病变风险增加有关。结论不同部位的脑白质病变发病机制可能存在不同,故二者的早期诊断和观察随访适用于不同的眼底血管网络几何学参数。姬晓昙 蔡颖 邱宝山 Benny Zee Jack Lee 蓝琳芳 范玉华 2019中华医学杂志2019,99,9:9
7Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats显示文摘AIM: To investigate the anti-diabetic effect of a crude ethanolic extract of Andrographis paniculata in normal and streptozotocin ( STZ )-induced diabetic rats. METHODS & RESULTS: Oral administration of the extract at different doses (0.1, 0.2, and 0.4 g/body weight) significantly reduced the fasting serum glucose level in STZ-diabetic rats compared to the vehicle (distilled water), but not in normal rats. This effect was dose-dependent. A similar result was seen with met-formin (0.5 g/body weight). In the glucose tolerance test, an oral administration of the extract at the same doses suppressed the elevated glucose level in normal and diabetic rats, as did metformin. The effects were also dose-respondent. In the long-term experiment, the extract (0.4 g/body weight), metformin (0.5 g/body weight), and vehicle were given twice daily to diabetic rats for 14 d. On d 15, fasting serum glucose levels were found to be significantly lower in the extract- and metformin-treated groups (P < 0.001) than in theBenny Kwong-Huat TAN 2000Acta Pharmacologica Sinica2000,21,12:9
8Effects of natural products on ischemic heart diseases and cardiovascular system显示文摘Ischemic heart diseases remain the leading cause of death in most developed countries as seen over the past quarter-century.Reducing the mortality rate and prevention of myocardial infarction (MI) are of utmost importance.The use of Western Medicinal drugs for the treatment of hypertension,congestive heart filure and post MI are widely accepted.Although some Traditional Chinese Medicines have been used in mainland,Hong Kong,Taiwan of China in clinics and other Chinese communities worldwide for centuries,our nuderstanding of the scientific principles of these herbal drugs is still far from satisfactory.As a result,their wide spread use in patients is limited throughout the world,especially in Western societies,although some of them could be used as complementary medicines in the treatment of Western medicines or tonics to maintain good health.The mechanisms of action and interaction,and the chemicals they contain remain undetermined in most Chinese traditional medicines,and need to be further elucidated using modem biological tools.Benny KH TAN Matthew WHITEMAN 2002Acta Pharmacologica Sinica2002,23,12:8
9Regional Scale Rainfall- and Earthquake-triggered Landslide Susceptibility Assessment in Wudu County, China显示文摘Wudu County in northwestern China frequently experiences large-scale landslide events.High-magnitude earthquakes and heavy rainfall events are the major triggering factors in the region.The aim of this research is to compare and combine landslide susceptibility assessments of rainfalltriggered and earthquake-triggered landslide events in the study area using Geographical Information System(GIS) and a logistic regression model.Two separate susceptibility maps were produced using inventories reflecting single landslide-triggering events,i.e.,earthquakes and heavy rain storms.Two groups of landslides were utilized: one group containing all landslides triggered by extreme rainfall events between 1995 and 2003 and the other group containing slope failures caused by the 2008 Wenchuan earthquake.Subsequently,the individual maps were combined to illustrate the locations of maximum landslide probability.The use of the resulting three landslide susceptibility maps for landslide forecasting,spatial planning and for developing emergency response actions are discussed.The combined susceptibility map illustrates the total landslide susceptibility in the study area.BAI Shi-biao CHENG Chen WANG Jian Benni THIEBES ZHANG Zhi-gang 2013Journal of Mountain Science2013,10,5:8
10Salvia miltiorrhiza and ischemic diseases显示文摘The demonstration of beneficial effects of salvia miltiorrhiza (DanShen) on ischemic diseases has revolutionized the management of angina pectoris, myocardial infarction (MI) or stroke in Chinese society. Experimental studies have shown that DanShen dilated coronary arteries, increased coronary blood flow, and scavenged free radicals in ischemic diseases, so that it reduced the cellular damage from ischemia and improved heart functions. Clinical trials also indicated that DanShen was an effective medicine for angina pectoris, MI, and stroke. This review will focus on DanShen’s effects in angina pectoris, MI and stroke.Xin-Yan JI, Benny K-H TAN, Yi-Zhun ZHU (Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore 119260, Singapore) 2000Acta Pharmacologica Sinica2000,21,12:8
11用于公众交通系统的分布式智能监控系统中的视听信息融合(英文)显示文摘提出了一个全新的概念 ,该概念表述了通过融合来自分布式视听处理系统的不同信息来提高事故检测鲁棒性以及提供更多的事件描述 .最后利用来自伦敦和巴黎的现场测试验证了该系统的性能 .Benny Ping Lai Lo Sergio A.Velastin 2003自动化学报2003,29,3:8
12Troponin not just a simple cardiac marker: prognostic significance of cardiac troponin显示文摘当在改变 circumstances.Data 的急性冠的症候群病人的一个预示的因素采购数据,这研究的对象是考察心脏的 troponin 的角色的目的在这评论使用了主要从从 1981~2006 .Study 选择在 pubmed 报导的心脏的 troponin 的研究被获得研究上的相关文章心脏的 troponin 是提高的 selected.Results 在有圣举起并且非的病人的心脏的 troponin 圣举起心肌的梗塞与 advers 被联系有提高的心脏的 troponin 价值的病人似乎包括经皮的冠的干预从侵略策略有益于更多并且绕过外科,但是提高了心脏的 troponin 也与不利结果被相关,包括在经历经皮的冠的干预的病人的失败,吃惊,和死亡的更高的度;外科也是的心肌的梗塞,低心脏的产量症候群,心肺的复活,和在经历的病人的新发作的室的心律不齐绕过的 perioperative 的更高的度观察了。在经皮的冠的干预以后的提高的 troponin 似乎与短期的不利结果而非长期的不利结果被联系,除非经皮的冠的干预是的 troponin 柱子的举起相当高(大约 5 倍上面的正常) 。相反,提高了心脏的 troponin 在以后绕过外科是自从它发生在几乎所有病人,糊涂分析的更多。而且,在截止价值的差别和在一些研究的时间大小增加更多的混乱;因此,进一步的研究是 warranted.Conclusions 心脏的 troponin 的预示的价值在几乎所有急性冠的症候群病人被表明。除了它的高敏感和特性,心脏的 troponin 的预示的价值是另一个原因做它“金色的心脏的 marker' 这次。Benny Mulyanto Setiadi LEI Han CHANG Jing 2009Chinese Medical Journal2009,,3:6
13脑小血管病与眼底血管网络参数的相关性研究显示文摘目的利用计算机辅助的全自动眼底照相分析技术,研究脑小血管病与眼底血管网络参数的相关性。方法连续性纳入能坐位行眼底照相的脑小血管病患者80例,大动脉粥样硬化性脑梗死患者41例,比较两组患者的一般临床资料和眼底血管网络参数。同时行logistic回归分析脑小血管病患者的危险因素。结果脑小血管病组在男性比例、吸烟史发生率、血尿酸水平方面均低于大动脉粥样硬化性脑梗死组[(55%vs.75.6%);(20%vs.39%);(308.33±85.30 vs.367.79±113.60)],差异均有统计学意义(P<0.05)。脑小血管病组小静脉分支系数和不对称性指数均小于大动脉粥样硬化性脑梗死组,[(1.37±0.04 vs.1.39±0.05);(0.80±0.02 vs.0.81±0.02)],差异均有统计学意义(P<0.05)。Logistic回归分析显示,调整血管危险因素后,减小的小静脉不对称性指数与脑小血管病相关,是其危险因素(OR值=1.16,95%CI:1.05-1.38,P<0.05)。结论减小的小静脉不对称性指数与脑小血管病相关,是其危险因素,可作为其早期诊断指标。姬晓昙 Benny Zee Jack Lee 林晶 王迪龙 范玉华 2016中国神经精神疾病杂志2016,42,2:6
14Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts.Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee 2014World Journal of Clinical Oncology2014,5,5:4
15Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson 2005World Journal of Gastroenterology2005,11,42:4
16关于幼儿喂食困难的临床研究:一套切实可行的方案显示文摘Benny Kerzner MBBCh 2010中国儿童保健杂志2010,18,7:3
17怎样重建公众对科学的信任显示文摘Benny Haerlin 刘学礼 2000世界科学2000,,2:3
18Inhibitory activities of extracts of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa, Ziziphus mauritiana as well as their compounds of gallic acid and emodin against dengue virus显示文摘Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue.Riffat Batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow 2018Asian Pacific Journal of Tropical Medicine2018,11,4:3
19Outcomes After Minimally Invasive Esophagectomy: Review of Over 1000 Patients显示文摘James D. Luketich Arjun Pennathur Omar Awais Ryan M. Levy Samuel Keeley Manisha Shende Neil A. Christie Benny Weksler Rodney J. Landreneau Ghulam Abbas Matthew J. Schuchert Katie S. Nason 2012Annals of Surgery2012,,1:3
20Reverse osmosis desalination: Water sources, technology, and today’s challenges显示文摘Lauren F. Greenlee Desmond F. Lawler Benny D. Freeman Benoit Marrot Philippe Moulin 2009Water Research2009,,9:3
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