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1Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential.Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot 2007World Journal of Gastroenterology2007,13,2:22
2Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/ ClPK6 calcium sensor/protein kinase complex显示文摘Katrin Held Franqois Pascaud Christian Eckert Pawel Gajdanowicz Kenji Hashimoto Claire Corratge-Faillie Jan Niklas Offenborn Benoit Lacombe Ingo Dreyer Jean-Baptiste Thibaud Jorg Kudla 2011Cell Research2011,21,7:23
3Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis显示文摘Dear Editor, In plants,the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types.The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis.AtSWEET1 was the first plant SWEET transporter to be characterized;it acts as a glucose uniporter in multiple systems (Chen et al.,2010).Rozenn Le Hir Lara Spinner Patrick A. W. Klemens Dipankar Chakraborti Federica de Marco Francoise Vilaine Nelly Wolff Remi Lemoine Benoit Porcheron Carine Gery Evelyne Teoule Salem Chabout Gregory Mouille H. Ekkehard Neuhaus Sylvie Dinant Catherine Bellini 2015Molecular Plant2015,8,11:16
4Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhvkwb556xvqxx60ox.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection.Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo 2020Plant Phenomics2020,2,1:13
5集料碱活性快速检测法对比研究显示文摘为探讨中国快速砂浆棒法(CAMBT)与其它集料碱活性快速检测法的相关性及对国外岩石的适应性,采用混凝土棱柱体法(CPT)、快速砂浆棒法(AMBT)、压蒸法和CAMBT研究了11种国外不同源集料的膨胀行为,同时还研究了集料颗粒尺寸对CAMBT中集料膨胀的影响.结果表明:CAMBT,AMBT及压蒸法的检测结果具有一致性,但均不能完全正确地判定这些集料的碱活性,它们在夸大RG集料碱活性的同时,还漏判了PO集料的碱活性;集料在现有快速法中的膨胀率与其在CPT中的膨胀率无明显相关性,因此快速法不能很好地表征集料在混凝土中的碱活性程度;CAMBT中集料颗粒尺寸对不同集料膨胀程度的影响不同,其中0.15~0.80mm集料颗粒尺寸对集料膨胀而言不是最敏感粒级;采用2.5~5.0mm单粒级集料颗粒,可以比现有标准检测方法更好地预测集料在混凝土中的膨胀行为.卢都友 许仲梓 吕忆农 唐明述 Benoit Fournier 2006建筑材料学报2006,9,4:12
6合作制还是商业化:信用合作社资本结构创新的实证分析显示文摘本文探讨了 2 0世纪 90年代以来西方信用合作社在全球化和金融机构并购浪潮中所面临的战略抉择 :合作制还是商业化 ;以个案分析的方式指出了各信用社在融资层面的不同做法 ,以及由此导致在合作制观念上的思路分歧和实践。BenoIt Tremblay Daniel Cté 2002金融研究2002,,1:12
7Molten salts-modified MgO-based adsorbents for intermediate-temperature CO_2 capture: A review显示文摘Carbon dioxide(CO2) capture using magnesium oxide(MgO)-based adsorbents at intermediate temperatures has been regarded as a very prospective technology for their relatively high adsorption capacity,low cost, and wide availability. During the past few years, great effort has been devoted to the fabrication of molten salts-modified MgO-based adsorbents. The extraordinary progress achieved by coating with molten salts greatly promotes the CO_2 capture capacity of MgO-based adsorbents. Therefore, we feel it necessary to deliver a timely review on this type of CO_2 capturing materials, which will benefit the researchers working in both academic and industrial areas. In this work, we classified the molten saltsmodified MgO adsorbents into four categories:(1) homogenous molten salt-modified MgO adsorbents,(2) molten salt-modified double salts-based MgO adsorbents,(3) mixed molten salts-modified MgO adsorbents, and(4) molten salts-modified MgO-based mixed oxides adsorbents. This contribution critically reviews the recent developments in the synthetic method, adsorption capacity, reaction kinetics, promotion mechanism, operational conditions and regenerability of the molten salts-modified MgO CO_2 adsorbents. The challenges and prospects in this promising field of molten salts-modified MgO CO_2 adsorbents in real applications are also briefly mentioned.Wanlin Gao Tuantuan Zhou Yanshan Gao Benoit Louis Dermot O'Hare Qiang Wang 2017Journal of Energy Chemistry2017,26,5:12
8锂离子在混凝土碱集料反应过程中的作用显示文摘在采用X射线衍射分析、化学组成分析和偏光显微镜分析对硅质碳酸盐集料的矿物学特征充分研究的基础上,研究了锂离子迁移渗透在混凝土碱集料反应过程中的行为特征.混凝土棱柱法(CSA A23.2-14A或ASTM C1293)所测的膨胀结果表明:掺加[Li]/[Na+K]摩尔比1.11的LiNO3能有效抑制混凝土碱集料反应膨胀;锂玻璃不仅不能抑制碱集料反应膨胀甚至会在一定程度上促进膨胀;与单一掺加混合材(粉煤灰或矿渣)相比,LiNO3与混合材的复合在一定程度上增强了相应的膨胀抑制效果;在混凝土碱集料反应过程中,存在Li+与Na+,K+之间的竞争.相对而言,Li+具有一定的优势.这与锂盐能表现出一定的混凝土碱集料反应膨胀抑制效果相一致.此外,强度对比研究结果表明,掺加锂盐一定程度上降低了混凝土的强度.俞琛捷 莫祥银 邓敏 唐明述 沈健 Benoit Fournier Klaus-Jurgen Hunger 2009东南大学学报(自然科学版)2009,39,1:11
9Seasonal,diurnal and nocturnal variations of carbonyl compounds in the semi-urban environment of Orléans,France显示文摘Atmospheric carbonyls were measured at a semi-urban site in Orléans, France, from October 2010to July2011. Formaldehyde, acetaldehyde and acetone were found to be the most abundant carbonyls, with average concentrations of 3.1, 1.0, 2.0 ppb, respectively in summer, 2.3, 0.7, 2.2 ppb, respectively in autumn, 2.2, 1.0, 2.1 ppb, respectively in spring,and 1.5, 0.7, 1.1 ppb, respectively in winter. Photo-oxidation of volatile organic compounds(VOCs) was found to make a remarkable contribution to atmospheric carbonyls in the semi-urban site based on the distinct seasonal and diurnal variations of the carbonyls, as well as the significantly positive correlations between the carbonyls and ozone. The significantly negative correlations between NO x and O_3 as well as the carbonyls and the positive correlations between wind speed and O_3 as well as the carbonyls implied that the carbonyls and O_3 at the semi-urban site were probably formed during air mass transport from neighboring cities.Zhaohui Jiang Benoit Grosselin Véronique Daele Abdelwahid Mellouki Yujing Mu 2016Journal of Environmental Sciences2016,28,2:10
10Air/CO2 cooling garment: Description and benefits of use for subjects exposed to a hot and humid climate during physical activities显示文摘The severity of the hot and humid conditions to which miners are exposed increases as the depth of the work site increases.This can cause heat stress that can greatly affect the health and safety of workers.To resolve this,a cooling garment has been developed that uses an atmospheric discharge of liquid CO2 to create a cool microclimate with an average temperature of 12.5(±0.4)℃ beneath the garment.To evaluate the garment's cooling efficiency,19 male subjects participated in an experimental procedure.The two modes,cooling on and off,were compared.Significant physiological differences were found between the two modes after minute 27(p<0.05)until the end of the recovery phase for the heart rate(maximum difference of 10 beats per minute)and the internal body temperature(maximum difference of 0.33℃).It was found that the modes also affected the subjects'perceptions.The ON-mode was associated with better well-being and thermal comfort,and reduced humidity sensation.Perceptions of exertion were lower in the ON-mode condition from minute 2.The findings provide strong evidence of the ability of this cooling garment to reduce heat stress in hot and humid conditions similar to those encountered in deep mines.Chady Al Sayed Ludwig Vinches Olivier Dupuy Wafa Douzi Benoit Dugue Stephane Halle 2019International Journal of Mining Science and Technology2019,29,6:10
11An air quality forecasting system in Beijing-Application to the study of dust storm events in China in May 2008显示文摘An air pollution forecast system,ARIA Regional,was implemented in 2007-2008 at the Beijing Municipality Environmental Monitoring Center,providing daily forecast of main pollutant concentrations.The chemistry-transport model CHIMERE was coupled with the dust emission model MB95 for restituting dust storm events in springtime so as to improve forecast results.Dust storm events were sporadic but could be extremely intense and then control air quality indexes close to the source areas but also far in the Beijing area.A dust episode having occurred at the end of May 2008 was analyzed in this article,and its impact of particulate matter on the Chinese air pollution index (API) was evaluated.Following our estimation,about 23 Tg of dust were emitted from source areas in Mongolia and in the Inner Mongolia of China,transporting towards southeast.This episode of dust storm influenced a large part of North China and East China,and also South Korea.The model result was then evaluated using satellite observations and in situ data.The simulated daily concentrations of total suspended particulate at 6:00 UTC had a similar spatial pattern with respect to OMI satellite aerosol index.Temporal evolution of dust plume was evaluated by comparing dust aerosol optical depth (AOD) calculated from the simulations with AOD derived from MODIS satellite products.Finally,the comparison of reported Chinese API in Beijing with API calculated from the simulation including dust emissions had showed the significant improvement of the model results taking into accountmineral dust correctly.Benoit Laurent Fanny Velay-Lasry Richard Ngo Claude Derognat Batrice Marticorena Armand Albergel 2012Journal of Environmental Sciences2012,24,1:9
12分形——自然界的几何学显示文摘分形几何扮演了两种角色.它既是决定论混沌的几何学,又是描述山峦、云团和星系的几何学. 自然科学与几何学总是携手并进的.17世纪,开普勒发现能用椭圆描述行星绕太阳运行的轨道.这激励了牛顿用万有引力定律解释这些椭圆轨道.同样,理想的摆做往复运动可以用正弦波形表示.简单的动力学常常和简单的几何外形相联系.这一种数学图像暗示,物体的形状和作用于它的力之间有一种平滑的关系.在行星和摆的例子中还暗示物理学是决定论的,由系统的过去便能预测其未来.Benoit Mandelbrot 王继振 1991世界科学1991,13,11:9
13Impact of organic interlayer anions on the CO2 adsorption performance of Mg-Al layered double hydroxides derived mixed oxides显示文摘Herein we report a systematical investigation on the promoting effect of the carbon chain length of the intercalated carboxylic anions on the CO_2 capture performance of Mg-Al layer double hydroxides(LDHs).A series of organo-LDHs were successfully synthesized via co-precipitation and calcination-rehydration methods. All as-prepared samples were characterized by many techniques including XRD, ATR-FTIR, BET,and TGA. The XRD and ATR-FTIR studies indicated that organic anions were successfully intercalated into LDHs. The influence of some important parameters such as calcination temperature, adsorption temperature, and coating with(Li-Na-K)NO_3 molten salt was investigated. The results exhibited that when the number of carbon is greater than 10, the CO_2 capture capacity steadily increased with the increase in carbon number. After coating with 55 mol%(Li-Na-K)NO_3 molten salt, the CO_2 uptake of LDH-C16 sample with high Mg/Al ratios can be increased up to 3.25 mmol/g. The CO_2 adsorption/desorption cycling stability was also studied using temperature swing adsorption, which showed a stable CO_2 capture performance even after 22 cycles. Considering its high CO_2 capture capacity and good cycling stability, this novel CO_2 adsorbent is very promising in the sorption-enhanced water gas shift(SEWGS) processes.Qingqing Qin Junya Wang Tuantuan Zhou Qianwen Zheng Liang Huang Yu Zhang Peng Lu Ahmad Umar Benoit Louis Qiang Wang 2017Journal of Energy Chemistry2017,26,3:8
14Tryptophan:A gut microbiota-derived metabolites regulating inflammation显示文摘Inflammatory bowel diseases(IBD), which comprise Crohn's disease and ulcerative colitis, are chronic intestinal disorders with an increased prevalence and incidence over the last decade in many different regions over the world. The etiology of IBD is still not well defined, but evidence suggest that it results from per-turbation of the homeostasis between the intestinal microbiota and the mucosal immune system, with the involvement of both genetic and environmental factors. Genome wide association studies, which involve large-scale genome-wide screening of potential polymorphism, have identified several mutations associated with IBD. Among them, Card9, a gene encoding an adapter molecule involved in innate immune response to fungi(via type C-lectin sensing) through the activation of IL-22 signaling pathway, has been identified as one IBD susceptible genes. Dietary compounds, which represent a source of energy and metabolites for gut bacteria, are also appreciated to be important actors in the etiology of IBD, for example by altering gut microbiota composition and by regulating the generation of short chain fatty acids. A noteworthy study published in the June 2016 issue of Nature Medicine by Lamas and colleagues investigates the interaction between Card9 and the gut microbiota in the generation of the microbiota-derived tryptophan metabolite. This study highlights the role of tryptophan in dampening intestinal inflammation in susceptible hosts.Lucie Etienne-Mesmin Benoit Chassaing Andrew T Gewirtz 2017World Journal of Gastrointestinal Pharmacology and Therapeutics2017,8,1:7
15昼夜温度对温室甜椒植株生长、发育和产量的影响(英文)显示文摘本试验的目的是为了探明不同昼夜温差 (DIF)对甜椒营养生长和生殖生长的影响 .甜椒种植于两个独立的玻璃温室内 ,采用岩棉培技术 .玻璃温室分别设两种 DIF处理 :昼温 2 0℃、夜温 16℃ (DIF+4℃ )和昼温 16℃、夜温 2 0℃ (DIF- 4℃ ) .结果表明 :负 DIF显著降低了甜椒 (品种 :Spirit)的节间长度与叶片大小 ,但对叶片展开速率、早熟性、产量和质量无显著影响 .正 DIF温室内甜椒植株比负DIF内的多消耗 31%的营养液 .与此相对应 ,随着甜椒植株的生长 ,从正 DIF温室内排出的多余营养液的 EC值随之提高 .负 DIF温室内的甜椒 (品种 :Spirit)果实加长生长更快 .而昼夜温度波动并不影响果实外观和内在品质 .不同品种对李国景 Benoit F Ceustermans N 2004浙江大学学报(农业与生命科学版)2004,30,5:7
16Comparative Transcriptomic Analysis of Salt Adaptation in Roots of Contrasting Medicago truncatula Genotypes显示文摘进化差异能被和不同环境的植物的相互作用驾驶。涉及生态的改编到不能生活的限制的分子的底能用 genomic 工具被探索。荚是世界范围的主要庄稼,土壤咸度是在这些植物影响产量的一个主要压力。我们在 Medicago truncatula 荚分析了让对比回答腌应力的二遗传型的根 transcriptome:TN1.11,在咸突尼斯的土壤,和参考 Jemalong A17 遗传型取样了。TN1.11 植物在盐应力以及钠离子的微分累积下面看增加的根生长是否与 A17 相比。Transcriptomic 分析揭示了盐优先地在 TN1.11 的根顶调整的特定的基因簇,尤其是那些与植物生长素小径有关并且到在 histone 变体 isoforms 的变化。编码抄写因素(TF ) 的许多基因也是响应盐在二遗传型之间调整的差别。在为功能的研究选择的那些之中,在大多数差别在遗传型之间调整了的 bHLH 类型 TF 的 A17 遗传型的根的 overexpression 显著地在盐应力下面改进了根生长。尽管有微分 transcriptional 回答的全球复杂性,我们建议这 bHLH TF 表情的增加可以被连接到 M 的改编。truncatula 到盐的土壤环境。Ons Zahaf Sandrine Blanchet Axel de Zelicourt Benoit Alunni Julie Plet Carole Laffont Laura de Lorenzo Sandrine Imbeaud Jean-Laurent lchante Anouck Diet Mounawer Badri Ana Zabalza Esther M. Gonzalez Herve Delacroix Veronique Gruber Florian Frugier Martin Crespi 2012Molecular Plant2012,5,5:7
17Growth simulation and yield prediction for perennial jujube fruit tree by integrating age into the WOFOST model显示文摘Mathematical models have been widely employed for the simulation of growth dynamics of annual crops,thereby performing yield prediction,but not for fruit tree species such as jujube tree(Zizyphus jujuba).The objectives of this study were to investigate the potential use of a modified WOFOST model for predicting jujube yield by introducing tree age as a key parameter.The model was established using data collected from dedicated field experiments performed in 2016-2018.Simulated growth dynamics of dry weights of leaves,stems,fruits,total biomass and leaf area index(LAI) agreed well with measured values,showing root mean square error(RMSE) values of 0.143,0.333,0.366,0.624 t ha^-1 and 0.19,and R2 values of 0.947,0.976,0.985,0.986 and 0.95,respectively.Simulated phenological development stages for emergence,anthesis and maturity were 2,3 and 3 days earlier than the observed values,respectively.In addition,in order to predict the yields of trees with different ages,the weight of new organs(initial buds and roots) in each growing season was introduced as the initial total dry weight(TDWI),which was calculated as averaged,fitted and optimized values of trees with the same age.The results showed the evolution of the simulated LAI and yields profiled in response to the changes in TDWI.The modelling performance was significantly improved when it considered TDWI integrated with tree age,showing good global(R2≥0.856,RMSE≤0.68 t ha^-1) and local accuracies(mean R2≥0.43,RMSE≤0.70 t ha^-1).Furthermore,the optimized TDWI exhibited the highest precision,with globally validated R2 of 0.891 and RMSE of 0.591 t ha^-1,and local mean R2 of 0.57 and RMSE of 0.66 t ha^-1,respectively.The proposed model was not only verified with the confidence to accurately predict yields of jujube,but it can also provide a fundamental strategy for simulating the growth of other fruit trees.BAI Tie-cheng WANG Tao ZHANG Nan-nan CHEN You-qi Benoit MERCATORIS 2020Journal of Integrative Agriculture2020,19,3:7
18The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases显示文摘Benoit Chassaing Arlette Darfeuille–Michaud 2011Gastroenterology2011,,6:6
19Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival显示文摘Autophagy is a cellular self-eating process essential for stress response and maintainingtissue homeostasis by lysosomal degradation of unwanted or damaged proteins and organelles.Here, we show that cells with defective mitochondria induce autophagy to promotecell survival through activating the AMPK pathway. Loss of mitochondrial complex III proteincytochrome b activates the AMPK signaling and induced autophagy. Inhibiting mitochondria energeticsby mitochondria-targeted agents activates the AMPK signaling and induced autophagy.Genetic inhibition of AMPK inhibits autophagy induction in cells with defective mitochondria,while genetic inhibition of autophagy has no effect on AMPK activation. Mitochondria dysfunctionhas no effect of DNA repair of UV-induced DNA damage. However, mitochondria dysfunctionsensitizes cells to apoptosis induced by UV radiation. Genetic inhibition of autophagy orAMPK sensitized cells to apoptosis in cells with defective mitochondria. Our results demonstratethat AMPK and autophagy senses mitochondria dysfunction and serves as a mechanismfor survival. Our findings may provide new insights into the interplay between mitochondriafunction and autophagy process in maintaining tissue homeostasis, and suggest that this interactionmay play important roles in diseases such as cancer and neurodegeneration.Baozhong Zhao Lei Qiang Joy Joseph Balaraman Kalyanaraman Benoit Viollet Yu-Ying He 2016Genes & Diseases2016,3,1:6
20Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias显示文摘AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications.Upper endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination.Two patients used as controls had normal endoscopy and histological results.Prospectively,videos were watched blind from histological results by three trained FICE technique endoscopists.RESULTS:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined.Videos did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of cases.CONCLUSION:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.Marine Camus Romain Coriat Sarah Leblanc Catherine Brezault Benoit Terris Elise Pommaret Marianne Gaudric Ariane Chryssostalis Frederic Prat Stanislas Chaussade 2012World Journal of Gastroenterology2012,18,16:5
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