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| 1 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | A review of process synthesis 显示文摘 | NISHIDA N STEPHANOPOULOS G WESTER- BERG A W | 1981 | AIChE J1981，27，： | 2 |
| 4 | Farming options for the Netherlands explored by multi-objective modeling 显示文摘 | TEN BERGE H F M VAN ITYERSUM M K ROSSING W A H | 2000 | Eur J Agron2000，13，23： | 1 |
| 5 | Direct versus indirect laryngoscopic visualization in human endotracheal intubation: a tool for virtual anesthesia practice and teleanes thesiology显示文摘 | Boedeker B H Berg B W Bernhagen M Murray W B | 2008 | Stud Health Technol Inform2008，132，： | 1 |
| 6 | Organic nitrogen uptake and growth by the chrysophyte Aureococcus anophagefferens during a brown tide event显示文摘 | BERG G M GLIBERT P M LOMAS M W | 1997 | Marine Biology1997，129，： | 1 |
| 7 | Organic nitrogen up take and growth by the chrysophyte Aureococcus anophageens during a brown tide event显示文摘 | BERG G M GLIBERT P M LOMAS M W | 1997 | Marine Biology1997，129，： | 1 |
| 8 | Water uptake and acid doping of polybenzimidazoles as electrolyte membranes for fuel cells显示文摘 | LI Q F HE R H BERG R W | 2004 | Solid State Ionics2004，168，12： | 1 |
| 9 | Single-Site Laparoscopic Colorectal Surgery Provides Similar Clinical Outcomes Compared With Standard Laparoscopic Surgery : An Analysis of 626 Patients 显示文摘 | Sangster W Messaris E Berg AS | 2015 | Dis Colon Rectum2015，58，9： | 1 |
| 10 | Tuning ionic liquids for high gas solubility and reversible gas sorption显示文摘 | H UANG J IISAGER A R BERG R W | 2008 | Molecular Catalysis2008，279，2： | 1 |
| 11 | Scarf and Well osteotomies for correction of rheumatoid forefoot deformities:a review of 20 cases 显示文摘 | Berg RP Kelder W Olsthoorn PGM | 2007 | Foot Ankle Surg2007，13，： | 1 |
| 12 | Long-term siol nitrogen and vegetation change on sandhill rangeland显示文摘 | Berg W A Bradford J A Smis P L | 1997 | Journal of Range Management1997，50，5： | 1 |
| 13 | Stuay of the initial stage of sintering by viscous flow,evaporation-condensation and self-diffusion显示文摘 | Kingery W D Berg M | 1955 | J Appl Phys1955，，： | 1 |
| 14 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 15 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 16 | Device for sampling and determination of total particulate mercury in ambient air显示文摘 | Lu J Y Schroeder W H Berg T | | 0，，11： | 1 |
| 17 | Flapping and flexible wings for biological and micro vehicles显示文摘 | Shyy W Berg M Ljungqvist D | | 0，，： | 1 |
| 18 | Pre- hospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (ON- TIME 2 ) : a multicentre, doubleblind, randomised controlled trial 显示文摘 | van't HOF A W TEN BERG J HEESTERMANS T | 2008 | Lancet2008，372，9638： | 1 |
| 19 | Storage of semen and artificial insemination in deer显示文摘 | Asher G W Berg D K Evans G | 2000 | Anim Reprod Sci2000，62，： | 1 |
| 20 | The local vascular to lerancetoan in travenou s in fusion of a con en trated glu tam in e solu tion in Icu patients显示文摘 | Berg A Forsb erg E W emerm an J | 2002 | C lin Nutr2002，21，2： | 1 |
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