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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Nasopharyngeal carcinoma in Indonesia:epidemiology,incidence,signs,and symptoms at presentation显示文摘Among all head and neck (H&N) cancers,nasopharyngeal carcinoma (NPC) represents a distinct entity regarding epidemiology,clinical presentation,biological markers,carcinogenic risk factors,and prognostic factors.NPC is endemic in certain regions of the world,especially in Southeast Asia,and has a poor prognosis.In Indonesia,the recorded mean prevalence is 6.2/100 000,with 13 000 yearly new NPC cases,but otherwise little is documented on NPC in Indonesia.Here,we report on a group of 1121 NPC patients diagnosed and treated at Dr.Cipto Mangunkusumo Hospital,Jakarta,Indonesia between 1996 and 2005.We studied NPC incidence among all H&N cancer cases (n=6000) observed in that period,focusing on age and gender distribution,the ethnic background of patients,and the disease etiology.We also analyzed most prevalent signs and symptoms and staging of NPC patients at first presentation.In this study population,NPC was the most frequent H&N cancer (28.4%),with a male-to-female ratio of 2.4,and was endemic in the Javanese population.Interestingly,NPC appeared to affect patients at a relatively young age (20% juvenile cases) without a bimodal age distribution.Mostly,NPC initiated in the fossa of Rosenmuller and spreaded intracranially or locally as a mass in the head.Occasionally,NPC developed at the submucosal level spreading outside the anatomic limits of the nasopharynx.At presentation,NPC associated with hearing problems,serous otitis media,tinnitus,nasal obstruction,anosmia,bleeding,difficulty in swallowing and dysphonia,and even eye symptoms with diplopia and pain.The initial diagnosis is difficult to make because early signs and symptoms of NPC are not specific to the disease.Early-age Epstein-Barr virus (EBV) infection combined with frequent exposure to environmental carcinogenic co-factors is suggested to cause NPC development.Undifferentiated NPC is the most frequent histological type and is closely associated with EBV.Expression of the EBV-encoded latent membrane protein 1(LMP1) oncogene in biopsy material was compared between NPC patients of <30 years old and those of ≥30 years old,matched for sex and tumor stage.Higher LMP1 expression in patients of <30 years old was observed,which was related to more locoregional progressivity.Increased medical awareness of prevailing early stage signs and symptoms coupled to use of EBV-related diagnostic tumor markers may lead to down-staging and timely treatment to improve survival of patients with this aggressive disease. | Marlinda Adham Antonius N.Kurniawan Arina Ika Muhtadi Averdi Roezin Bambang Hermani Soehartati Gondhowiardjo I Bing Tan Jaap M.Middeldorp | 2012 | Chinese Journal of Cancer2012，31，4： | 22 |
| 3 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 4 | 国际糖尿病足工作组:糖尿病足溃疡预防指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and evaluation)的评分方法,采用以患者为观察对象、有干预措施、与对照组进行比较、观察结局(patient-intervention-comparison-outcome,PICO)的方法来设计临床问题和关键成果,对医学科学文献进行系统评价,并撰写推荐意见及其理由。这些推荐基于系统评价中发现的证据质量、专家意见,以及益处及危害的权重、患者偏好、可行性和适用性以及与干预相关成本的权衡。我们建议对处于极低溃疡风险的患者每年做一次筛查,了解其是否有周围神经病变和外周血管病变,对高风险人群检查的频率要更高,以筛查其他危险因素。为了预防足溃疡,要对有危险因素的患者进行健康教育,教育患者适当地对足部进行自我护理以及对溃疡前症状进行有效治疗。指导中高危患者穿着合适的治疗鞋,并对其足部皮肤温度进行监测。处方治疗鞋在行走过程中具有明显的减轻足底压力的效果,能够防止足底溃疡复发。急性足溃疡或即将发生的足溃疡保守治疗失败,应考虑手术干预。我们不建议使用神经松解减压术。对高危患者给予综合足部医疗护理,以防溃疡复发。贯彻这些推荐将有助于医疗专业人员对有足溃疡风险的糖尿病患者提供更好的护理,降低糖尿病足溃疡的发生率,使足部健康维持更长的时间即增加无足病的天数,显著减少糖尿病患者和医疗机构的负担。 | Sicco A.Bus Larry A.Lavery Matilde Monteiro-Soares Anne Rasmussen Anita Raspovic Isabel C.N.Sacco Jaap J.van Netten 无 罗颖琪 李炳辉(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，3： | 14 |
| 5 | 45S rDNA在4种百合属植物染色体上的物理定位显示文摘利用荧光原位杂交的技术将45SrDNA在麝香百合(Lilium longiflorum),柠檬色百合(L.leichtlinii),天香百合(L.auratum)和豹纹百合(L.pardalinum)的染色体上进行了定位。结果表明:45S rDNA在这4种植物中都分布于染色体的着丝点附近,但其位点数量、所在的染色体和信号的强弱有很大的变化。其中,麝香百合和豹纹百合中各有3对染色体在着丝点附近有45S rDNA的信号,柠檬色百合和天香百合中各有4对染色体在着丝点附近有45S rDNA的信号。但是天香百合的两对中部染色体的着丝点附近都有45S rDNA的信号,柠檬色百合的两对中部染色体中只有一条有45S rDNA的信号,而麝香百合和豹纹百合中没有任何一条有45S rDNA的信号。由于这4种百合在百合属中分别属于不同组,其45S rDNA的位点数量、所在染色体和信号强弱的变化为这种分组的合理性提供了一些分子生物学的证据。 | 周树军 Jaap van Tuyl 臧德奎 夏宜平 李方 | 2008 | 园艺学报2008，35，6： | 13 |
| 6 | 欧洲卒中组织(ESO)关于无活动能力的急性缺血性卒中患者静脉血栓栓塞的预防指南显示文摘背景静脉血栓栓塞(venous thromboembolism, VTE)包括深静脉血栓形成(deep vein thrombosis, DVT)和肺栓塞,是无活动能力的急性缺血性卒中患者的常见并发症。本文阐述了欧洲卒中组织(European Stroke Organisation, ESO)关于无活动能力的急性缺血性卒中患者VTE预防的指南。有关出血性卒中的指南已发表。方法一个多学科小组确定了相关问题并使用推荐意见分级评估、制定和评价系统根据随机对照试验证据制定推荐意见。本文经过ESO内部及外部评审,并得到ESO指南委员会和ESO执行委员会批准。结果我们发现的主要是中等质量证据,包括评估梯度压力弹力袜(graduated compression stocking, GCS)、间歇充气加压装置(intermittent pneumatic compression, IPC)以及使用普通肝素(unfractionated heparin, UFH)、低分子量肝素(low molecular weight heparin, LMWH)和类肝素进行预防性抗凝治疗的随机对照试验和系统评价,但未发现评估神经肌肉电刺激(neuromuscular electrical stimulation, NES)的随机试验。我们推荐临床医生对无活动能力的患者使用IPC,但不应使用GCS。在无活动能力的缺血性卒中患者中,如果降低VTE风险的益处足以抵消其使用导致的颅内外出血风险增高,则应考虑使用UFH(5 000 U,2~3次/d)、LMWH或类肝素进行预防性抗凝治疗。如果确定具有预防性抗凝治疗的指征,应考虑使用LMWH或类肝素而非UFH,因为前两者能更明显地降低DVT风险,使用更加便利,人员成本更低,患者舒适度更高(每天仅需注射1次),但这些优势应与LMWH和类肝素的更高颅外出血风险、更高药物成本以及在肾功能不全老年患者中使用的相关风险进行权衡。结论IPC、UFH或LMWH和类肝素可降低无活动能力的急性缺血性卒中患者的VTE风险,但需要进一步研究来评价NES是否有效。其中证据最强的预防手段是IPC。需要更好的方法在卒中发病后最初数周内根据VTE风险和抗凝药的出血风险对患者进行分层。 | Martin Dennis Valeria Caso L Jaap Kappelle Aleksandra Pavlovic Peter Sandercock 刘品一 黄丽丽 徐运 | 2017 | 国际脑血管病杂志2017，25，3： | 11 |
| 7 | Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial显示文摘 | Harold P. Adams Birgitte H. Bendixen L. Jaap Kappelle José Biller Betsy B. Love David Lee Gordon E. Eugene Marsh | 1993 | Stroke1993，，1： | 9 |
| 8 | Concept and application of ideal protein for pigs显示文摘Knowledge about the amino acid requirements and the response of pigs to the amino acid supply is essential in feed formulation.A deficient AA supply results in a reduction in performance while an oversupply is costly and leads to excessive nitrogen excretion with a potentially negative environmental impact.Amino acid requirements are determined to a large extent by the protein deposition in the body and,for lactating sows,by the protein exported in the milk.The concept of ideal protein was developed more than 50 years ago and refers to a protein with an amino acid profile that exactly meets the animal's requirement so that all amino acids are equally limiting for performance.Because Lys typically is the first-limiting amino acid,the ideal amino acid profile is often expressed relative to Lys.Although the ideal protein profile is often assumed to be constant for a given production stage,(small) changes in the ideal protein profile can occur within a production stage.This can be caused by changes in the relative contribution of the different components of amino acid requirements during the productive life on the animal(e.g.changes in the relative contribution of growth and maintenance).Amino acids requirements can be determined experimentally using dose-response studies.The design of the study,the chosen response criterion,and the statistical model affect the requirement estimate.Although considerable experimental work has been carried out to determine the requirements for Lys,Met,Thr,and Trp in growing pigs(and to a lesser extent in sows),little is known about the requirements for the other essential amino acids.Experimental dose-response studies generally focus on the requirement and less on the overall response(i.e.what are the consequences of an amino acid deficiency?).This latter aspect is,to some extent,accounted for in modelling approaches that quantify the response of the animal to the amino acid supply in a dynamic way.The paper describes the origin of ideal protein and illustrates how fundamental concepts of amino acid nutrition have been integrated in practical modeling approaches for the nutrition of growing pigs and sows. | Jaap van Milgen Jean-Yves Dourmad | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 8 |
| 9 | 国际糖尿病足工作组:糖尿病足防治实践指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘糖尿病足给全球糖尿病患者以及卫生保健系统带来沉重的负担。国际糖尿病足工作组(The International Working Group on the Diabetic Foot,IWGDF)自1999年起一直致力于制定基于循证的糖尿病足防治指南。2019年,在文献系统综述以及全球多学科领域专家推荐意见的基础上,对IWGDF的所有指南进行了更新。本实践指南在IWGDF指南第六部分的基础上阐述了糖尿病足的预防、分类和治疗的基本原则。同时,阐述了如何基于这些原则从组织层面成功地预防与治疗糖尿病足,并提供了用于辅助糖尿病足筛查的附录(见附录1和附表1)。本实践指南针对的是全球参与糖尿病患者医疗照护的医务人员。全球大量的研究证实,实施这些防治原则与降低糖尿病相关的下肢截肢发生率有关。我们希望这些更新的实践指南能继续作为有效参考文件以帮助卫生保健人员减轻全球糖尿病足的负担。 | Nicolaas C.Schaper Jaap J.van Netten Jan Apelqvist Sicco A.Bus Robert J.Hinchliffe Benjamin A.Lipsky 无 周秋红 许景灿(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，3： | 8 |
| 10 | Analysis of the meiosis in the F_1 hybrids of Longiflorum × Asiatic(LA) of lilies(Lilium) using genomic in situ hybridization显示文摘Longiflorum and Asiatic lilies of the genus Lilium of the family Liliaceae are two important groups of modern lily cultivars.One of the main trends of lily breeding is to realize introgression between these groups.With cut style pollination and embryo rescue,distant hybrids between the two groups have been obtained.However,the F1 hybrids are highly sterile or some of them could produce a small number of 2n gametes,and their BC1 progenies are usually triploids.Dutch lily breeders have selected many cultivars from these BC1 progenies based on their variation.It is presumably suggested that such variation could be caused by intergenomic recombination and abnormal meiosis during gamete formation in F1 hybrids of Longiflorum × Asiatic(LA) hybrids in Lilium.Therefore,the meiotic process of ten F1 LA hybrids was cytologically investigated using genomic in situ hybridization and traditional cytological methods in the present research.The results showed that:at metaphase I,the homoeologous chromosome pairing among different F1 hybrids ranged from 2.0 to 11.4 bivalents formed by homoeologous chromosomes per pollen mother cell(PMC),and very few multivalents,and even very few bivalents were formed by two chromosomes within one genome rather than homoeologous chromosomes in some PMCs;at anaphase I,all bivalents were disjoined and most univalents were divided.Both the disjoined bivalents(half-bivalents) and the divided univalents(sister chromatids) moved to the opposite poles,and then formed two groups of chromosomes;because the two resulting half-bivalents retained their axes in the cell undisturbed,many crossover types,including single crossovers,three strand double crossovers,four strand double crossovers,four strand triple crossovers,and four strand multiple crossovers between the non-sister chromatids in the tetrads of bivalents,were clearly inferred by analyzing the breakpoints on the disjoined bivalents.The present investigation not only explained the reason for sterility of the F1 LA hybrids and the variation of their BC1 progenies,but also provided a new method to analyze crossover types in other F1 interspecific hybrids as well. | Shujun Zhou Munikote S. Ramanna Richard G.E Visser Jaap M. van Tuyl | 2008 | Journal of Genetics and Genomics2008，35，11： | 8 |
| 11 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 12 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
| 13 | Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults显示文摘 | Sabine M.J.M. Straus Jan A. Kors Marie L. De Bruin Cornelis S. van der Hooft Albert Hofman Jan Heeringa Jaap W. Deckers J. Herre Kingma Miriam C.J.M. Sturkenboom Bruno H. Ch. Stricker Jacqueline C.M. Witteman | 2006 | Journal of the American College of Cardiology2006，，2： | 4 |
| 14 | 变频调速灯泡贯流泵装置结构开发与优化显示文摘针对南水北调工程江苏段和山东段低扬程泵站的具体特点,开发了新型结构的灯泡贯流泵机组,并采用变频调速装置进行工况调节。根据使用常规电动机和永磁电动机两种设计方案,进行了灯泡体尺寸和出水流道型线优化设计,利用商用软件CFX对贯流泵装置内部流场开展内部流动数值分析和性能预测。数值计算和模型装置试验结果表明,合理增加流道外壳直径和减小电动机外径,都能有效提高贯流泵装置效率,不同特征扬程下效率提高0.5~3.7%。 | 张仁田 Jaap Arnold 朱红耕 于国平 | 2010 | 水力发电学报2010，29，5： | 4 |
| 15 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 16 | 国际糖尿病足工作组:指南的发展和方法学——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘糖尿病足不仅给患者带来巨大的折磨,还给社会带来沉重的经济负担。本指南是以目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病足病指南有良好的经济-效益比。国际糖尿病足工作组(IWGDF)从1999年起开始发布和更新国际指南。IWGDF在着眼于相关临床问题和结局、严谨的文献系统评价、最大可能给予明确而清晰的推荐及其依据的基础上发布了2019年版指南更新。相关推荐均基于推荐评估和评价系统(GRADE)。本文阐述《IWGDF:糖尿病足防治国际指南(2019)》(简称《IWGDF指南》)的制定过程。《IWGDF指南》中指南共6个部分,分别由6个国际专家组编写,从预防、减压、周围动脉病变、感染、创面愈合干预及糖尿病足溃疡分级6个方面提出推荐意见。IWGDF编辑委员会分别从上述6个方面制定了一系列的实践指南,每条推荐意见均经过IWGDF编辑委员会成员和相关领域国际专家的深入评估。我们相信,只要相关专业人员遵循2019版IWGDF指南推荐,并将这些推荐与本地具体情况相结合,就能够进一步改善糖尿病足的预防和治疗水平,同时也会减轻糖尿病足给全世界患者和社会所带来的负担。 | Sicco A.Bus Jaap J.van Netten Jan Apelqvist Robert J.Hinchliffe Benjamin A.Lipsky Nicolaas C.Schaper 无 严同(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，4： | 4 |
| 17 | Endoscopic and Percutaneous Preoperative Biliary Drainage in Patients with Suspected Hilar Cholangiocarcinoma显示文摘 | Jaap J. Kloek Niels A. Gaag Yalda Aziz Erik A. J. Rauws Otto M. Delden Johan S. Lameris Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2010 | Journal of Gastrointestinal Surgery2010，，1： | 3 |
| 18 | 栽培亚麻的遗传多样性研究显示文摘基于110份来源于世界各地的亚麻(Linum usitatissimum)资源(栽培品种和育种材料)和1个野生近缘种L.bienne,利用AFLP技术研究形态学上不同的亚麻,即纤维亚麻和油用亚麻的遗传多样性。聚类分析结果表明,L.bienne明显区别于其他样品,自展值高;纤维亚麻与油用亚麻和不明用途亚麻也能区别开来,但自展值偏低。主成份分析显示,纤维亚麻与油用亚麻区别明显,但L.bienne与油用亚麻之间难以区别,荷兰、法国的纤维亚麻与其他国家的纤维亚麻亦可明显区别,这说明亚麻基因库出现了类群结构。分子方差分析显示,纤维亚麻的变异度低于油用亚麻及不明用途亚麻,因此,油用亚麻和野生亚麻L.bienne是丰富纤维亚麻基因库的潜在种质资源。 | Jaap Vromans 刘飞虎 郑婷 龙波 | 2011 | 中国麻业科学2011，33，3： | 3 |
| 19 | Biological Soil Disinfestation (BSD), a new control method for potato brown rot, caused by Ralstonia solanacearum race 3 biovar 2显示文摘 | Nevein A. S. Messiha Anne D. Diepeningen Marcel Wenneker Alexander R. Beuningen Jaap D. Janse Trudie G. C. Coenen Aad J. Termorshuizen Ariena H. C. Bruggen Wim J. Blok | 2007 | European Journal of Plant Pathology2007，，4： | 3 |
| 20 | The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy显示文摘The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs,thereby contributing to several aspects of adaptive immunity and immune tolerance.In the present study,we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis(CIA).By using a novel anti-human CCR7 antibody and humanized CCR7 mice,we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis(RA).Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II(CII).Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers.Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression,respectively.Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA. | Georgios L.Moschovakis Anja Bubke Michaela Friedrichsen Jasmin Ristenpart Jaap Willem Back Christine S.Falk Elisabeth Kremmer Reinhold Forster | 2019 | Cellular & Molecular Immunology2019，16，10： | 3 |
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