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507篇 您的检索式:作者名="BERGER R M"
    题名 作者 年代 出处 被引量
1Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy.Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski 2007World Journal of Gastroenterology2007,13,26:4
2B-type natriuretic peptide predicts sudden death in patients with chronic heart failure显示文摘Berger R Huelsman M Strecker K 0,,:2
3Lithium ion induced surface reativity change on MgO nanoparticles显示文摘BERGER R SCHUH J STERRER M DIWALD O KNOZINGER E 2007J Catalysis2007,247,:1
4A comparative study of the corrosion protective properties of chromium and chromium free passivation methods显示文摘Berger R Bexell U Grehk T M 2007Surface and Coatings Technology2007,202,2:1
5B - type natriuretic peptide predicts sudden death in patients with chronic heart failure显示文摘Berger R Huelsman M Strecker K 2002Circulation2002,105,20:1
6An ecological ' footprint' of climate change显示文摘Walther G R Berger S Sykes M T 2005Proceedings of the Royal Society B: Bio logical Sciences2005,272,:1
7A framework for validation ofcomputermodels显示文摘Bayarri M J Berger J O Paulo R 2007Technometrics2007,49,2:1
8B - natriuretic peptide preddicts sudden in patients with chronic hear failure 显示文摘Berger R Huelsman M Strecker K 2002Circulation2002,105,:1
9Indication practice arid procedural outcomes of PTCA in Northern New England in the early 1990s显示文摘M alleuka DJ Laham R J Berger C et a l 1996Am J Cardiol1996,78,:1
10Generation of cell diversity and segmental pattern in the embryonic central nervous system of Dro- sophila显示文摘Technau G M Berger C Urbach R 2009Dev Dyn2009,235,4:1
11B-type natriuretic peptide predicts sudden death in patients with chronic heart failure 显示文摘Berger R Huelsman M Strecker K 2002Circulation2002,105,20:1
12A new 'miniSTR-multiplex' displaying reduced amplicon lengths for the analysis of degraded DNA显示文摘Grubwieser P Mühlmann R Berger B 2005Int J Legal Med2005,13,:1
13Laparoscopic partial nephrectomy: a decade of evolution显示文摘BERGER A K STEIN R J ARON M 2011J Endourol2011,25,2:1
14B-type natriuretic peptide predicts sudden death in patients with chronic heart failure显示文摘BERGER R HUELSMAN M STEEKER K 2002Circulation2002,105,:1
15Relationship between dobutamine response of dyssynergic myocardial and angiographically documented blood supply显示文摘Klaar U Berger R Gwechenberger M 2003J Am Soc Echocardiogr2003,16,9:1
16B-type natriuretic peptide predicts sudden death in patients with chronic heart failure显示文摘BERGER R HUELSMAN M STRECKER K 2002Circulation2002,105,20:1
17Multiple sclerosis - estab -lished and noveltherapeutic approaches 显示文摘Ehling R Berger T Reindl M 2010Cent Nerv Syst Agents Med Chem2010,10,1:1
18Fine diameter ceramic fibers显示文摘Bunsell A R Berger M H 0,,13:1
19B-type natriuretic peptide predicts sudden death in patients with chronic heart failure 显示文摘Berger R Huelsman M Strecker K 2002Circulation2002,10,5:1
20B-type natriuretic peptide predicts sudden death in patients with chronic heart failure显示文摘Berger R Huelsman M Streeker K 2002Circulation2002,105,20:1
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