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| 1 | Cyclophilin A通过调控炎症/免疫反应介导动脉粥样硬化显示文摘 | 廖端芳 庹勤慧 郭琰 Berk B C | 2009 | 中国动脉硬化杂志2009，17，7： | 5 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 4 | ,The crystal structure of α, α-trehalose dihydrate from Three independent X-ray determinations 显示文摘 | BROWN G M ROHRE D C BERKING B | 1972 | Acta Crystallogr1972，28，： | 1 |
| 5 | Vascular smooth muscle growth: autocrine growth mechanisms显示文摘 | BERK B C | 2001 | Physiol Rev2001，81，： | 1 |
| 6 | The Tat protein export pathway显示文摘 | Berks B C Sargent F Palmer T | 2000 | Molecular microbiology2000，35，2： | 1 |
| 7 | A common export pathway for proteins binding complex redox cofactors?显示文摘 | Berks B C | 1996 | Molecular microbiology1996，22，3： | 1 |
| 8 | The Effects of Lidocaine and Adrenergic Agonists on Rat Sciatic Nerve and Skeletal Muscle Blood Flow In Vivo显示文摘 | Palmer G M Cairns B E Berkes S L | 2002 | Anesth Analg2002，95，： | 1 |
| 9 | Vascular smooth muscle growth: autocrine growth mechanisms显示文摘 | BERK B C | 2001 | Physiol Rev2001，81，3： | 1 |
| 10 | Toll-like receptor triggering in cord blood mesenchymal stem cells显示文摘 | van den Berk LC Jansen B J Siebers-Vermeulen KG | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 11 | Cyclophilin A: promising new target in cardiovascular therapy 显示文摘 | SATOH K SHIMOKAWA H BERK B C | 2010 | Circ J2010，74，11： | 1 |
| 12 | Angiotensin II signal trausduction in vascular smooth muscle: role of tymsine kinases显示文摘 | Berk B C Corson M A | 1997 | Circ Res1997，80，6： | 1 |
| 13 | Scientific Workflow Management and the Kepler System显示文摘 | Ludaescher B Altintas I Berkely C | 2006 | Concurrency and Computation:Practice and Experience2006，18，10： | 1 |
| 14 | 14-3-3 is a p90 Ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase aetivity显示文摘 | Cavet M E Lehoux S Berk B C | 2003 | J Biol Chem2003，278，18： | 1 |
| 15 | Transactivation: a novel signaling pathway from angiotensin Ⅱ to tyrosinekinase receptors 显示文摘 | Berk B C | 2001 | J Mol Cell Cardiol2001，33，1： | 1 |
| 16 | Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilinA 显示文摘 | SATOH K NIGM P BERK B C | 2010 | Antioxid Redox signal2010，12，5： | 1 |
| 17 | Toll-like receptor triggering in cord blood mesenchymal stem cells显示文摘 | Van den Berk LC Jansen B J Siebers-Vermeulen KG | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 18 | Hypertrophy and hyperplasia cause differing effects on vascular smooth muscle cell Na+/H+exchange and intracellular pH显示文摘 | Berk B C Elder E Mitsuka M | 1990 | J Biol Chem1990，265，19： | 1 |
| 19 | Cyclophilin A: promising new target in cardiovascular therapy显示文摘 | SATOH K SHIMOKAWA H BERK B C | 2010 | Circ J2010，74，11： | 1 |
| 20 | 5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma显示文摘 | Torres A Niemeyer A Berkes B | 2004 | Dermatol Surg2004，30，121： | 1 |
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