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| 1 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 2 | Clinical significance ofantibiotic therapy of surgical disvases显示文摘 | Jezioro Z Bernat M Bielawski J | 1962 | Polski Tygodnik Lvkarski1962，17，： | 1 |
| 3 | Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells显示文摘Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide(NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness. | Amparo Beltran-Povea Estefania Caballano-Infantes Carmen Salguero-Aranda Franz Martín Bernat Soria Francisco J Bedoya Juan R Tejedo Gladys M Cahuana | 2015 | World Journal of Stem Cells2015，7，3： | 1 |
| 4 | Clopidogrel hychrogensulfate 显示文摘 | HERBERT J M FRENEL D BERNAT A | 1993 | Drugs Fut1993，18，2： | 1 |
| 5 | Potentiating eff ect of clopidogrel and SR 45349 a novel 5-HT2 antagonist on streptokinase-in duced thrombolysis in the rabbit显示文摘 | Bernat A Sainte-marie M Dol F Rinaldi M | 1993 | Thromb Haemost1993，69，： | 1 |
| 6 | The anti- aggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit 显示文摘 | HERBERT J M DOL F BERNAT A | 1998 | Thromb Haemost1998，80，3： | 1 |
| 7 | Respirometric activity of activated sludge in sequencingbatch reactor depending on substrate and dissolved oxy- gen concentration 显示文摘 | Zielinska M Bernat M Cydzik-Kwiatkowska A | 2012 | Environ Prot Eng2012，38，2： | 1 |
| 8 | Variations de la teneur en eau des coraux lors de la transformation aragonite→calcite显示文摘 | Baumer A Ganteaume M Bernat M | 1993 | Thermochim Acta1993，221，2： | 1 |
| 9 | Robustness of the European power grids under intentional attack显示文摘 | SOLE R V MARTI R C BERNAT C M | 2008 | Physical Review E2008，77，02： | 1 |
| 10 | Decomposing ERP time-frequency energy using PCA显示文摘 | BERNAT E M WILLIAMS W J GEHRING W J | 2005 | Clinical Neurophysiology2005，116，： | 1 |
| 11 | Synthesis of thrombin- inhibiting heparin mimetics without side effects显示文摘 | Petitou M Herauh JP Bernat A | 1999 | Nature1999，398，41： | 1 |
| 12 | Robustness of the Eu- ropean power grids under intentional attack显示文摘 | SOLt R V MART R C BERNAT C M | 2008 | Physical Review E2008，77，2： | 1 |
| 13 | Ammonification rates and 210Pb in sediments from a lagoon climate:Marica,Rio de Janerio state,Brazil显示文摘 | BERNAT M BALLESTRA S | 1992 | Hydrobiologia1992，242，： | 1 |
| 14 | Simultaneous toxic action of zinc and alachlor resulted in enhancement of zinc uptake by the filamentous fungus Paecilomyces marquandii 显示文摘 | SLABA M SZEWCZYK R BERNAT P | 2009 | Science of the Total Environment2009，407，13： | 1 |
| 15 | A study of the ethical duty of physicians to disclose errors显示文摘 | Sweet M P Bernat J L | 1997 | The Journal of Clinical Ethics1997，8，4： | 1 |
| 16 | Evolution of binder strueture in soditm silicte-activated slag-metakataolin blends显示文摘 | Bernat S A Provis J L Rose V de Gutierrez R M | 2011 | Cement & Concrete Composites2011，33，： | 1 |
| 17 | A weighted small world network measure for assessing functional connectivity 显示文摘 | Bolanos M Bernat E M He B | 2013 | Journal of Neuroscience Methods2013，212，1： | 1 |
| 18 | Efficient alachlor degradation by the filamentous fungus Paecilomyces marquandii with simultaneous oxidative stress reduction显示文摘 | Slaba M Ra Zalska S Bernat P | 2015 | Bioresour Technol2015，197，： | 1 |
| 19 | Rapid identification of single nucleotide polymorphisms by fluorescence-based capillary electrophoresis显示文摘 | Bernat M Tiros E Clària J | 2002 | Genet Mol Res2002，1，1： | 1 |
| 20 | FosB,a cysteine-dependent fosfomycin resistance protein under thecontrol of W,an extracytoplasmic-function factor inBacillus subtilis 显示文摘 | Cao M Bernat B A Wang Z | 2001 | J Bacteriol2001，183，7： | 1 |
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