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| 1 | 实验性铅染毒对大鼠体内锌、钙的影响显示文摘以0、200、500、1000ppm含铅饮用水使大鼠染毒,在4、8、12周分批处死动物,取血、尿及组织分别测定铅、锌、钙等元素。结果表明,染毒200ppm动物在4周时即出现全身症状;血铅浓度随染毒剂量增加而增高;尿铅、锌、钙的排出呈平行关系,排出高峰在第4周。高尿锌导致脑、睾丸、骨、胰腺等组织锌含量降低,说明锌在铅中毒的发生机制中起重要作用。 | 李凭建 朱士雅 RO BE RT A.GO YE R | 1997 | 中国公共卫生学报1997，16，5： | 7 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | Irradiation Induces a Biphasic Expression of Pro-Inflammatory Cytokines in the Lung显示文摘 | Claudia E. Rübe MD Falk Wilfert Jan Palm Jochem K?nig Susanne Burdak-Rothkamm Li Liu Andreas Schuck Normann Willich Christian Rübe | 2004 | Strahlentherapie und Onkologie2004，，7： | 2 |
| 6 | The Wisconsin Epidemiologic Study of Diabetic Retinopathy, X Ⅶ : the 14 year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes显示文摘 | Klein R Klein BE Moss SE | 1998 | Ophthalmology1998，105，10： | 1 |
| 7 | Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one compartment model显示文摘 | Van Beers BE Smith AM | 2000 | Clin Sci2000，99，6： | 1 |
| 8 | Mechanisms guiding primordial germ cell migration:strategies from different organisms显示文摘 | Richardson BE Lehmann R | 2010 | Nat Rev Mol Cell Biol2010，11，1： | 1 |
| 9 | Evolution of multiresistance in non -typhoid Salmonella serovars from 1984 to 1998 in Argentina 显示文摘 | Orman BE Arduino M Galas R | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 10 | Human pancreatic islets produce and secrete MCP-1/CCL2:relevance in human islet transplantation显示文摘 | PIEMONTI L LEONE BE NANO R | 2002 | Diabetes2002，51，1： | 1 |
| 11 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 12 | The effects of COX-1 and COX-2 in- hibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model显示文摘 | Rapuano BE Boursiquot R Tomin E | 2008 | Arch Orthop Trauma Surg2008，128，： | 1 |
| 13 | The association between se- rum uric acid level and long-term incidence of hypertension: Popu- lation-based cohort study显示文摘 | Shankar A Klein R Klein BE | 2006 | J Hum Hypertens2006，20，12： | 1 |
| 14 | Long-term risk of cancer in membranous nephropathy patients显示文摘 | Bjomeklett R Vikse BE Svarstad E | 2007 | Am J Kidney Dis2007，50，3： | 1 |
| 15 | Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam显示文摘 | Klein BE Klein R Lee KE | 2002 | Diabetes Care2002，25，10： | 1 |
| 16 | Stem cell therapy in perspective 显示文摘 | Strauer BE Kornowski R | 2003 | Circulation2003，107，7： | 1 |
| 17 | Exposure to low-level chemicals and ionizing radiation: reactive oxygen species and cellular pathways显示文摘 | Lehnert BE Iyer R | 2002 | Hum Exp Toxicol2002，21，2： | 1 |
| 18 | Disappear anee of pink- pigmented Globigerinoides ruber at 120 000 yr B P in the Indian and Pacific Oceans 显示文摘 | Thompson P R Be A W H Duplesy J C | 1999 | Nature1999，280，： | 1 |
| 19 | The relation of retinal microvascular characteristics to age-related eye disease:the Beaver Dam eye study显示文摘 | Klein R Klein BE Tomany SC Wong TY | | 0，，3： | 1 |
| 20 | Long-term interfer- on gamma therapy for patients with chronic granulomatous dis- ease 显示文摘 | Marciano BE Wesley R De Carlo ES | 2004 | Clin Infect Dis2004，39，： | 1 |
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