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| 1 | Expression of interleukin-2 receptor on blood lymphocytes stimulated with allogeneic lymphocytes or autologous tumor cells显示文摘 | G. Stuber F. Vánky E. Pócsik M. Benczúr E. Klein | 1990 | Cancer Immunology Immunotherapy1990，，2： | 4 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 3 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 4 | A new Early Cretaceous dinosaur track assemblage and the first definite non-avian theropod swim trackway from China显示文摘The trackway of a swimming theropod (ichnogenus Characichnos) is reported from the Lower Cretaceous Feitianshan Formation of Sichuan, China. These swim tracks help confirm that non-avian theropods were capable of forging moderately deep bodies of water. The trackway occurs on the same surface as a typical walking trackway of a sauropod (ichnogenus Brontopodus). Both occurrences are the first reported from the Cretaceous of Sichuan, and the swim tracks are the first well-preserved example of a Characichnos trackway from China. Additionally, a theropod walking trackway and several ornithopod walking trackways (similar to the ichnogenus Caririchnium) occur in the same horizon. The ornithopod trackways show a parallel orientation, suggesting gregarious behavior of the trackmakers, which may have been iguanodontiforms and/or hadrosauriforms. The co-occurrence of theropod swim tracks and theropod walking tracks suggests a fluctuation of water depth within a distinct time span. | XING LiDa LOCKLEY Martin G ZHANG JianPing MILNER Andrew R C KLEIN Hendrik LI DaQing PERSONS IV W Scott EBI JieFang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 5 | Measurement of muscle activity with magnetic resonance elastography显示文摘 | Guido Heers Thomas Jenkyn M. Alex Dresner Marc-Oliver Klein Jeffrey R Basford Kenton R Kaufman Richard L Ehman Kai-Nan An | 2003 | Clinical Biomechanics2003，，6： | 2 |
| 6 | Induction of T helper cell type 1 response and elidriation of HBeAg during treatineni with IL-12 in a patiat with therapy refractory chronic hepatitis B显示文摘 | Barth H Klein R Berg PA | 2001 | Hepatogastroenterology2001，48，： | 2 |
| 7 | Randomized assessment of syncope trial:conventional diagnostic testing versus a prolonged monitoring strategy显示文摘 | Krahn AD Klein GJ Yee R | 2001 | Circulation2001，104，1： | 2 |
| 8 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 9 | Cytokine gene polymorphisms in patients infected with hepatitis B virus显示文摘 | Ziv Ben-Ari Eytan Mor Orit Papo Batia Kfir Jaqueline Sulkes Anat R Tambur Ran Tur-Kaspa Tirza Klein | 2003 | The American Journal of Gastroenterology2003，，1： | 2 |
| 10 | Expression of cytokeratine 20 in urinary cytology of patients with bladder carcinoma显示文摘 | Klein A Zemer R Buchumensky V | 1998 | Cancer1998，82，2： | 2 |
| 11 | Investigations on the reestablishment of the positive feedback of estradiol during anestrus in the bitch显示文摘 | Klein R Schams D Failling K | 2003 | Reprod Dom Anita2003，38，： | 1 |
| 12 | Transitios cell hyperplasia and Carcinomas in urinary bladders of transgeanic mice with kcratin 5 promoter-driven cyclooxygenase-2 overexpression 显示文摘 | Klein R D Van Pelt C S Sabichi AL | 2005 | Cancer Res2005，65，5： | 1 |
| 13 | The Wisconsin Epidemiologic Study of Diabetic Retinopathy, X Ⅶ : the 14 year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes显示文摘 | Klein R Klein BE Moss SE | 1998 | Ophthalmology1998，105，10： | 1 |
| 14 | Cooperating attackers in neural cryptography显示文摘 | Shacham L N Klein E Mislovaty R | 2004 | Phys Rev E2004，69，： | 1 |
| 15 | Efficient 3D modeling of vibration isolation by open trenches显示文摘 | Klein R Antes H LeHouedec D | 1997 | Computers and Structures1997，64，： | 1 |
| 16 | A note on negative thermal expansion coefficients显示文摘 | KLEIN M J MOUNTAIN R D | 1962 | J Phys ChemSolids1962，23，： | 1 |
| 17 | Complement factor H polymorphism in age-related macular degeneration显示文摘 | Klein R J Zeiss C Chew E Y Tsai J Y Sackler R S Haynes C | 2005 | Science2005，308，： | 1 |
| 18 | Polyurethanepolysiloxane interpenetrating polymer networks ( 1 ) : A polyether urethane-poly ( dimethyl siloxane ) system 显示文摘 | EBDON J R HOURSTON D J KLEIN P G | 1984 | Polymer1984，25，11： | 1 |
| 19 | Open Circuit Voltage Improvement of High Deposition Rate Microcrystalline Silicon Solar Cells by Hot Wire Interface Layers 显示文摘 | Mai Y Klein S Carius R | 2005 | Appl Phys Lett2005，87，07： | 1 |
| 20 | The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 显示文摘 | Klein R Nanduri V Jing S A | 1991 | Cell1991，66，2： | 1 |
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