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| 1 | Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach显示文摘AIM: To evaluate the ability of Curcuma longa (CL) and Tinospora cordifolia (TC) formulation to prevent anti-tuberculosis (TB) treatment (ATT) induced hepatotoxicity. METHODS: Patients with active TB diagnosis were randomized to a drug control group and a trial group on drugs plus an herbal formulation. Isoniazid, rifampicin, pyrazinamide and ethambutol for first 2 mo followed by continuation phase therapy excluding Pyrazinamide for 4 mo comprised the anti-tuberculous treatment. Curcumin enriched (25%) CL and a hydro-ethanolic extract enriched (50%) TC 1 g each divided in two doses comprised the herbal adjuvant. Hemogram, bilirubin and liver enzymes were tested initially and monthly till the end of study to evaluate the result. RESULTS: Incidence and severity of hepatotoxicity was significantly lower in trial group (incidence: 27/192 vs 2/316, P < 0.0001). Mean aspartate transaminase (AST) (195.93 ± 108.74 vs 85 ± 4.24, P < 0.0001), alanine transaminase (ALT) (75.74 ± 26.54 vs 41 ± 1.41, P < 0.0001) and serum bilirubin (5.4 ± 3.38 vs 1.5 ± 0.42, P < 0.0001). A lesser sputum positivity ratio at the end of 4 wk (10/67 vs 4/137, P = 0.0068) and decreased incidence of poorly resolved parenchymal lesion at the end of the treatment (9/152 vs 2/278, P= 0.0037) was observed. Improved patient compliance was indicated by nil drop-out in trial vs 10/192 in control group (P < 0.0001). CONCLUSION: The herbal formulation prevented hepatotoxicity significantly and improved the disease outcome as well as patient compliance without any toxicity or side effects. | Meghna R Adhvaryu Narsimha M Reddy Bhasker C Vakharia | 2008 | World Journal of Gastroenterology2008，14，30： | 13 |
| 2 | Electrical conductivity and dielectric properties of zinc substituted lithium ferrites prepared by sol-gel method显示文摘 | Vijaya Bhasker Reddy P Ramesh B Gopal Reddy C | | 0，，： | 1 |
| 3 | Flow simulation in Electro-Static-Precipitator (ESP) ducts with turning vanes显示文摘 | Bhasker C | 2011 | Advances in Engineering Software2011，42，7： | 1 |
| 4 | Flow simulation in industrial cyclone separator 显示文摘 | Bhasker C | 2010 | Advances in Engineering Software2010，41，2： | 1 |
| 5 | Numerical simulation of turbulent flow in complex geometries used in power plants 显示文摘 | BHASKER C | 2002 | Advances in Engineering Software2002，33，1： | 1 |
| 6 | Flow analysis in valve with moving grids through CFD techniques显示文摘 | SRIKANTH C BHASKER C | 2009 | Advances in Software Engineering2009，40，3： | 1 |
| 7 | Numerical simulation of turbulent flow in complex geometries used in power plant显示文摘 | Bhasker C | 2002 | Advances in Engineering Software2002，33，： | 1 |
| 8 | Numerical simulation of turbulent flow in complex geometries used in power plant显示文摘 | Bhasker C | 2002 | Advances in Engineering Software2002，33，： | 1 |
| 9 | Numerical simulation of turbulent flow in complex geometries used in power plants 显示文摘 | Bhasker C | 2002 | Advances in Engineering Software2002，33，： | 1 |
| 10 | Numerical simulation of turbulent flow in complex geometries used in power plant显示文摘 | Bhasker C | 2002 | Advances in Engineering Software2002，，33： | 1 |
| 11 | Flow Analysis in Valve with Moving GridsThrough CFD Techniques 显示文摘 | Srikanth C Bhasker C | 2009 | Advances in Engineering Software2009，40，3： | 1 |
| 12 | Flow Analysis in Valve with Moving Grids Through CFD Techniques显示文摘 | Srikanth C Bhasker C | 2009 | Advances in Engineering Software2009，40，3： | 1 |
| 13 | Genetic polymorphsim of UDP-glucuronosyltrans ferase 2B7 (UGT2B7) at amino acid 268: Ethnic diversity of alleles and potential clinical significance 显示文摘 | BHASKER C R MCKINNON W STONE A | 2000 | Pharmacogenetics2000，10，： | 1 |
| 14 | Opportunities for marker-assisted selection (MAS) to improve the feed quality of crop residues in pearl millet and sorghum显示文摘 | Hasha C T Bhasker A G Raja | 2003 | Field Crops Research2003，84，： | 1 |
| 15 | Genetic polymorphism of UDP-glucuronosyltransferase 2B7 ( UGT2B7 ) at amino acid 268: ethnic diversity of alleles and potential clinical significance 显示文摘 | BHASKER C R MCKINNON W STONE A | 2000 | Pharmacogenetics2000，10，8： | 1 |
| 16 | Ca^2+/calmodulin kinase-depe ndent activation of hypoxia inducible factor 1 transcriptional activity in ceils subjected to intermittent hypoxia显示文摘 | Yuan G Nanduri J Bhasker C R | 2005 | J Biol Chem2005，280，6： | 1 |
| 17 | Numerical simulation of turbulent flow in complex geometries used in power plants显示文摘 | BHASKER C | 2002 | Advances in Engineering Software2002，33，1： | 1 |
| 18 | Flow Analysis in Valve with Moving Grids through CFD Techniques显示文摘 | SRIKANTH C BHASKER C | 2009 | Advances in Engineering Software2009，40，3： | 1 |
| 19 | Numerical simulation of turbulent flow in complex geometries used in power plants显示文摘 | BHASKER C | 2002 | Advances in Engineering SoRware2002，33，2： | 1 |
| 20 | Simulation of air flow in the typical boiler windbox segments显示文摘 | BHASKER C | 2002 | Advances in Engineering Software2002，33，1112： | 1 |
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