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| 1 | Progress Towards Genetics and Breeding for Minor Genes Based Resistance to Ug99 and Other Rusts in CIMMYT High-Yielding Spring Wheat显示文摘Wheat rusts continue to cause signif icant losses worldwide despite major efforts given to their genetic control.This is due to frequent evolution and selection of virulence in pathogen overcoming the deployed race-specific resistance genes.Although the life of effective race-specif ic resistance genes can be prolonged by using gene combinations,an alternative approach being implemented at CIMMYT is to deploy varieties that posses adult plant resistance(APR)based on combinations of minor,slow rusting genes.When present alone,the APR genes do not confer adequate resistance especially under high disease pressure;however,combinations of 4 or 5 minor genes usually result in'near-immunity'or a high level of resistance.Although only a few APR genes are catalogued,various APR QTLs are now known and could lead to further characterization of additional genes.Four characterized genes have pleiotropic effects in conferring partial APR to all 3 rusts and powdery mildew,thus simplifying the task of breeding wheat varieties that are resistant to multiple diseases.Significant progress was made recently in developing high-yielding wheat germplasm that possesses high levels of APR to all three rusts by implementing a MexicoKenya shuttle breeding scheme.Parents with APR to Ug99 were hybridized with high-yielding parents that had adequate to high levels of APR to leaf rust and yellow rust.Segregating populations and advanced lines from these crosses were selected under high rust pressures in Mexico(leaf rust and yellow rust)and Kenya(Ug99 stem rust and yellow rust)to identify highyielding progenies that possess high to adequate APR to all three rusts.International distribution of these high-yielding wheats is underway through CIMMYT international yield trials and screening nurseries.It is expected that several wheat varieties with APR to three rusts will be released and grown in various countries in the near-future that will allow determining the durability of resistance. | Ravi Prakash Singh Sybil Herrera-Foessel Julio Huerta-Espino Sukhwinder Singh Sridhar Bhavani Caixia Lan Bhoja Raj Basnet | 2014 | Journal of Integrative Agriculture2014，13，2： | 3 |
| 2 | Three co-located resistance genes confer resistance to leaf rust and stripe rust in wheat variety Borlaug 100显示文摘Leaf rust(LR) and stripe rust(YR) are important diseases in wheat producing areas worldwide and cause severe yield losses under favorable environmental conditions when susceptible varieties are grown. We determined the genetic basis of resistance to LR and YR in variety Borlaug 100 by developing and phenotyping a population of 198 F6 recombinant inbred lines derived from a cross with the susceptible parent Apav#1. LR and YR phenotyping were conducted for 4 and 3 seasons, respectively, at CIMMYT research stations in Mexico under artificial epidemics. Mendelian segregation analyses indicated that 3–5 LR and 2 YR genes conferred resistance in Borlaug 100. Lr46/Yr29(1 BL), Yr17(2 AS) and Yr30(3 BS) were present in the resistant parent and segregated in the RIL population based on characterization by molecular markers linked to these genes. When present alone, Lr46/Yr29 caused average 13% and 16% reductions in LR and YR severities, respectively, in RILs. Similarly, Yr17 and Yr30 reduced YR severities by 57% and 11%, respectively. The Yr30 and the Yr17 translocation were also associated with 27% and 14% reductions, respectively, in LR severity, indicating that the 3 BS and 2 AS chromosomal regions likely carry new slow rusting LR resistance genes, temporarily designated as Lr B1 and Lr B2, respectively. Additive effects of Yr30*Yr17, Yr29*Yr17 and Yr29*Yr30 on YR and LR were significant and reduced YR severities by 56%,55%, and 45%, respectively, and LR severities by 34%, 40%, and 45%, respectively. Furthermore, interaction between the three genes was also significant, with mean reductions of 70% for YR and 54% for LR severities. Borlaug 100, or any one of the 21 lines with variable agronomic traits but carrying all three colocated resistance loci, can be used as resistance sources in wheat breeding programs. | Bowei Ye Ravi P.Singh Chan Yuan Demei Liu Mandeep S.Randhawa Julio Huerta-Espino Sridhar Bhavani Evans Lagudah Caixia Lan | 2022 | The Crop Journal2022，10，2： | 3 |
| 3 | 成纤维细胞的力学生物学(上)显示文摘由于重力、血液的流动及运动的原因,人体会不断受到力的作用。众所周知,结缔组织是承受与传导力的器官,其内的细胞可以通过多种机制将力转化为生物化学信号,但是有些机制尚未完全了解。结缔组织的成纤维细胞就是对力产生反应的细胞,在力的作用下,会通过改变自身细胞外基质(extracellular matrix,ECM)的基因及蛋白质表达的方法维持组织的结构和功能(如创伤修复)。当结缔组织承受到较大的压力时,可以使结缔组织保持正常的功能和组织的动态平衡。结缔组织的修复及维持主要由间充质细胞或成纤维细胞来完成。力可以调节细胞的多种功能,如细胞增殖、基因表达及蛋白质分泌。 | James HC Wang Bhavani P Thampatty | 2007 | 中华骨科杂志2007，27，5： | 3 |
| 4 | lpxA/lpxC/lpxD基因突变致鲍曼不动杆菌耐多黏菌素作用机制显示文摘目的探讨细胞膜脂质A生物合成基因lpxA/lpxC/lpxD突变导致鲍曼不动杆菌临床株对多黏菌素耐药的机制。方法用透射电子显微镜(TEM)观察细菌细胞壁、细胞内外膜的变化;用气相色谱(GC)法定量测定脂肪酸含量观察脂多糖(LPS)的变化。此外,用分子生物学方法确定菌株编码细胞膜脂质生物合成的lpxA/lpxC/lpxD基因突变。结果 TEM显示多黏菌素耐药鲍曼不动杆菌细胞外膜和内膜完整性降低,失去细胞壁膜间隙的均一性。GC结果表明短碳链饱和脂肪酸和脂肪酸醇有下降趋势,且几乎失去了所有的未知脂肪酸,但长碳链饱和、不饱和脂肪酸和脂肪酸醇的量都增加了。参与细胞膜脂质生物合成的lpx、lpxC和lpxD基因发现有缺失、点突变和插入等改变。结论多黏菌素耐药鲍曼不动杆菌存在lpxA/lpxC/lpxD基因突变及细胞内外膜改变。 | 张文利 Joan-Miquel Balada-Llasat Vijay Pancholi Bhowmik Aurosree Bhavani Gopalakrishnan Preeti Pancholi | 2015 | 中国感染与化疗杂志2015，15，6： | 2 |
| 5 | Large solitary ovarian metastasis from colorectal cancer diagnosed by endoscopic ultrasound显示文摘A case is presented of rectal carcinoma in which during staging by endoscopic ultrasound (EUS) a second large extrarectal mass was seen not otherwise visualized on computer tomograghy (CT) that was a solitary ovarian metastasis. The surgeon was alerted to the EUS f inding prior to the planned laparoscopic colectomy. On retro spective review of the CT pelvis after surgery, the radi ologist could still not diagnose the ovarian lesion sepa rated from the primary rectal tumor due to their close proximity. However, on EUS we were able to clearly see on real-time imaging that there was a distinct peri-recta mass apart from the primary rectal tumor. | Bhavani Moparty Guillermo Gomez Manoop S Bhutani | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 6 | Hemodynamics during laporoseopic surgery in pregnancy 显示文摘 | Steinbrook RA Bhavani Shankar K | 2001 | Anesth Analg2001，93，6： | 1 |
| 7 | Arterial to end-tidal carbon dioxide pressure difference during laparoscopic surgery in pregnancy 显示文摘 | Bhavani Shankar K Steinbrook RA Brooks DC | 2000 | Anesthesiology2000，93，2： | 1 |
| 8 | Data mining for malicious code detection and security applications 显示文摘 | THURAISINGHAM BHAVANI | 2009 | Web Intelligence and Intelligent Agent Technologies2009，，5： | 1 |
| 9 | Security constraint processing in a multilevel secure distributed database management system显示文摘 | Bhavani Thuraisingham and William Ford | 1995 | IEEE Transactions on Knowledge and Data Engineering1995，7，2： | 1 |
| 10 | Cerebrospinal fluid 20-HETE is associated with delayed cerebral ischemia and poor outcomes after aneurysmal subaraehnoid hemorrhage显示文摘 | Elizabeth AC Bhavani PT Paula RS | 2011 | Stroke2011，42，： | 1 |
| 11 | Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells显示文摘 | Bhavani K de la Monte S Brown NV | 1995 | Alcohol Clin Exp Res1995，19，： | 1 |
| 12 | An overview on biological mechanism of PPARs显示文摘 | Bhavani PK Tom HWH Basil DR | 2005 | Pharmaco Res2005，51，2： | 1 |
| 13 | Late postpartumeclampsia显示文摘 | Chhabra S Tyagi S Bhavani M | 2012 | J Obstet Gynaecol2012，32，3： | 1 |
| 14 | Thermal stresses in functionally graded beams显示文摘 | Sankar Bhavani V Tzeng Jerome T | 2002 | AIAA Journal2002，40，6： | 1 |
| 15 | Progress in breeding for resistance to Ug99 and other races of the stem rust fungus in CIMMYT wheat germplasm显示文摘Races belonging to the Ug99(TTKSK) lineage of the wheat stem rust fungus, carrying complex virulence combinations, and their migration to countries in Africa,Middle East and Asia continue to pose a significant threat to global wheat production.The rapid spread of additional races, e.g., TKTTF or the Digalu lineage, in several countries causing localized epidemics reminds us of the vulnerability of wheat germplasm to stem rust disease, a formidable foe referenced as early as biblical times.A global rust monitoring system reflecting increased surveillance efforts has identified 13 races within the Ug99 lineage in 13 countries and unrelated lineages are emerging, spreading and posing serious threats to wheat production.Race TKTTF has caused localized epidemics in Ethiopia and its variants have been recently implicated in stem rust outbreaks in Europe.Concerted research efforts have resulted in the identification of several new resistance genes and gene combinations for use in breeding.Combining multiple adult plant resistance(APR) genes in high-yielding backgrounds and discovery of new quantitative trait loci conferring stem rust resistance has progressed in the recent years, enhancing the durability of resistance.Effective gene stewardship and new generation breeding materials and cultivars that combine multiple race-specific or minor to intermediate effect APR genes,complemented by active surveillance and monitoring, have helped to limit major epidemics and increase grain yield potential in key target environments. | Sridhar BHAVANI David PHODSON Julio HUERTA-ESPINO Mandeep SRANDHAWA Ravi PSINGH | 2019 | Frontiers of Agricultural Science and Engineering2019，6，3： | 1 |
| 16 | A novel trifunctional organocatalyst for the asymmetric aldol re- action:a facile enantioselective synthesis of -hydroxyk- ctones 显示文摘 | REDDY B V S BHAVANI K RAJU A | 2011 | Tetrahedron : Asymmetry2011，22，： | 1 |
| 17 | Emerging Standards for Data Mining显示文摘 | Bhavani Thuraisingham | 2001 | Computer Standards & Interfaces2001，23，： | 1 |
| 18 | Age,nutritional status and INH acetylator status affect pharmacokinetics of anti-tuberculosis drugs in children显示文摘 | Ramachandran G Hemanth Kumar AK Bhavani PK | 2013 | Int J Tuberc Lung Dis2013，17，6： | 1 |
| 19 | The effect of stitching on the low-velocity impact response of delaminated composite beam 显示文摘 | Sankar Bhavani V Zhu Huasheng | 2000 | Composites Science and Technology2000，60，： | 1 |
| 20 | EUS-guided FNA for the diagnosis of GI stromal cell tumors: sensitivity and cytologic yield显示文摘 | Paul S. Sepe Bhavani Moparty Martha B. Pitman John R. Saltzman William R. Brugge | 2009 | Gastrointestinal Endoscopy2009，，2： | 1 |
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