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| 1 | Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry显示文摘Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and yohimbine.Reserpine,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in hypertension.Yohimbine is an aphrodisiac used in dietary supplements.As there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion mode.We identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and yohimbine.The MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS analysis.Reserpine,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia vomitoria.Application of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species. | Sunil Kumar Awantika Singh Vikas Bajpai Mukesh Srivastava Bhim Pratap Singh Brijesh Kumar | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 7 |
| 2 | T-connected autotransformer-based 24-pulse AC-DC converter for variable frequency induction motor drives显示文摘 | Bhim Singh Bhuvanewari G Vipin Garg | 2006 | IEEE Transactions on Energy Conversion2006，21，3： | 1 |
| 3 | Selective compensation of power-quality problems through active power filter by current decomposition显示文摘 | Bhim Singh Vishal Verma | 2008 | IEEE Transactions on Power Delivery2008，23，2： | 1 |
| 4 | Solid State Voltage and Frequency Controller for a Stand Alone Wind Power Generating System显示文摘 | Bhim Singh Gaurav Kumar Kasal | 2008 | IEEE Transactions on Power Electronics2008，23，3： | 1 |
| 5 | Autoeonnect- ed-transformer-based 20-pulse AC-DC converter for telecommuni- cation power supply 显示文摘 | KALPANA R BHUVANESWARI G SINGH Bhim | 2013 | IEEE Transactions on Industrial Elec- tronics2013，60，10： | 1 |
| 6 | A comparison of control algorithms for DSTATCOM显示文摘 | Bhim Singh Jitendra Solanki | 2009 | IEEE Transactions on Industial Electronics2009，56，7： | 1 |
| 7 | A Review of Three Phase Improved Power Quality AC/DC Converters显示文摘 | Bhim Singh Brij N Singh Ambrish Chandra | 2004 | IEEE Transactions on Industrial Electronics2004，51，3： | 1 |
| 8 | An autonomous wind energy conversion system with permanent magnet synchronous generator显示文摘 | Shailendra Sharma Bhim Singh | 2011 | IEEE Transactions on Energy Conversion2011，11，10： | 1 |
| 9 | A review of active filters for power quality improvement显示文摘 | Bhim Singh Kamal A1 Haddad Ambrish Chandra | | 0，，： | 1 |
| 10 | DFIG-based wind power conversion with grid power leveling for reduced gusts 显示文摘 | Vijay Chand Ganti Bhim Singh Shiv Kumar Aggarwal | 2012 | IEEE Transactions on Energy Conversion2012，3，1： | 1 |
| 11 | Load Compensation for Diesel Generator-based Isolated Generation System Employing DSTATCOM显示文摘 | Bhim Singh Jitendra Solanki | | 0，，01： | 1 |
| 12 | A review of active filters for power qulity improve显示文摘 | Bhim Singh Kamal A1-Haddad Ambrish Chandra | 1999 | IEEE Trans on IE1999，46，5： | 1 |
| 13 | An Implementation of an Adaptive Control Algorithm for a Three-Phase Shunt Active Filter显示文摘 | Bhim Singh Jitendra Solanki | 2009 | IEEE Transactions on Industrial Electronics2009，56，8： | 1 |
| 14 | Perfaormance Analysis of Fuzzy Logic Controlled Permanent Magnet Synchronous Motor Drive 显示文摘 | BHIM Singh PUTTA Swamy C L | 1995 | Industrial Electronic Control and lnstrumenttation1995，，： | 1 |
| 15 | A Review of Active Filters for Power Quality hnprovement显示文摘 | Bhim Singh Kamal AI-Haddad | 1999 | IEEE Trans on Industrial Electronics1999，46，5： | 1 |
| 16 | A review of active power filters for power quality improvement显示文摘 | Singh Bhim Al-haddad Kamal Chandra Ambrish | | 0，，05： | 1 |
| 17 | A Three Phase Active Power Filter for Harmonic and Reactive Power Compensation显示文摘 | Bhim Singh Ambrish Chandra Kamal Al - Haddad | 1996 | Canadian Conference on Electrical & Computer Engg1996，，2： | 1 |
| 18 | Selective Compensation of Power-Quality Problems Through Active Power Filter by Current Decomposition 显示文摘 | Bhim Singh Vishal Verma | 2008 | IEEE Trans on Power Delivery2008，23，4： | 1 |
| 19 | Selective compensation of power-quality problems through active power filter by current decomposition 显示文摘 | Bhim Singh Vishal Verma | 2008 | IEEE Transactions on Power Delivery2008，23，2： | 1 |
| 20 | A comparison of conlrol algorithms for DSTATCOM显示文摘 | Bhim Singh Jitendra Solanki | 2009 | IEEE Transactions on Industrial Electronics2009，56，7： | 1 |
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