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| 1 | Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry显示文摘Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and yohimbine.Reserpine,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in hypertension.Yohimbine is an aphrodisiac used in dietary supplements.As there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion mode.We identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and yohimbine.The MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS analysis.Reserpine,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia vomitoria.Application of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species. | Sunil Kumar Awantika Singh Vikas Bajpai Mukesh Srivastava Bhim Pratap Singh Brijesh Kumar | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 7 |
| 2 | Creatinine sensor based on a molecularly imprinted polymer-modified hanging mercury drop electrode显示文摘 | Dhana L Bhim B P Piyush S S | 2006 | Talanta2006，，70： | 1 |
| 3 | T-connected autotransformer-based 24-pulse AC-DC converter for variable frequency induction motor drives显示文摘 | Bhim Singh Bhuvanewari G Vipin Garg | 2006 | IEEE Transactions on Energy Conversion2006，21，3： | 1 |
| 4 | Selective compensation of power-quality problems through active power filter by current decomposition显示文摘 | Bhim Singh Vishal Verma | 2008 | IEEE Transactions on Power Delivery2008，23，2： | 1 |
| 5 | Solid State Voltage and Frequency Controller for a Stand Alone Wind Power Generating System显示文摘 | Bhim Singh Gaurav Kumar Kasal | 2008 | IEEE Transactions on Power Electronics2008，23，3： | 1 |
| 6 | Autoeonnect- ed-transformer-based 20-pulse AC-DC converter for telecommuni- cation power supply 显示文摘 | KALPANA R BHUVANESWARI G SINGH Bhim | 2013 | IEEE Transactions on Industrial Elec- tronics2013，60，10： | 1 |
| 7 | Double-ion imprinted polymer @ magnetic nanoparticles modified screen printed carbon electrode for simultaneous analysis of cerium and gadolinium ions 显示文摘 | Bhim Bali Prasad Darshika Jauhari | 2015 | Ana- lytiea Chimica Acta2015，875，： | 1 |
| 8 | A comparison of control algorithms for DSTATCOM显示文摘 | Bhim Singh Jitendra Solanki | 2009 | IEEE Transactions on Industial Electronics2009，56，7： | 1 |
| 9 | A review of single- phase improved power quality AC-DC converters 显示文摘 | Bhim S Brij N S Ambrish C | 2003 | IEEE Transactions on Industrial Electronics2003，50，5： | 1 |
| 10 | Preparation,characterization and performance of a silica gel bonded molecularly imprinted polymer for selective recognition and enrichment of β -lactam antibiotics显示文摘 | Bhim B P Shouri B | 2003 | Reactive & Functional Polymers2003，55，2： | 1 |
| 11 | A Review of Three Phase Improved Power Quality AC/DC Converters显示文摘 | Bhim Singh Brij N Singh Ambrish Chandra | 2004 | IEEE Transactions on Industrial Electronics2004，51，3： | 1 |
| 12 | An autonomous wind energy conversion system with permanent magnet synchronous generator显示文摘 | Shailendra Sharma Bhim Singh | 2011 | IEEE Transactions on Energy Conversion2011，11，10： | 1 |
| 13 | A review of active filters for power quality improvement显示文摘 | Bhim Singh Kamal A1 Haddad Ambrish Chandra | | 0，，： | 1 |
| 14 | A STATCOM based voltage regulator for parallel operated isolated asynchronous generators feeding three-phase four-wire loads显示文摘 | Gaurav K K Bhim S | 2009 | International Journal of Power Electronics2009，1，3： | 1 |
| 15 | Intereropping of wheat and pea as influenced by nitrogen fertilization 显示文摘 | Bhim B Ghaley H H | 2005 | Nutrient Cycling In Agroeeosystems2005，73，： | 1 |
| 16 | Household Characteristics and Forest Dependency: Evidence from Common Property Forest Management in Nepal 显示文摘 | Bhim Adhikari Salvatore Di Falcol Jon C Lovett | 2004 | Ecological Economics2004，，48： | 1 |
| 17 | DFIG-based wind power conversion with grid power leveling for reduced gusts 显示文摘 | Vijay Chand Ganti Bhim Singh Shiv Kumar Aggarwal | 2012 | IEEE Transactions on Energy Conversion2012，3，1： | 1 |
| 18 | Intercropping of wheat and pea as influenced by nitrogen fertilization显示文摘 | Ghaley Bhim Hauggaard-Nielsen H Hugh-Jensen H | 2005 | Nutrient Cycling in Agroecosystems2005，73，2： | 1 |
| 19 | Load Compensation for Diesel Generator-based Isolated Generation System Employing DSTATCOM显示文摘 | Bhim Singh Jitendra Solanki | | 0，，01： | 1 |
| 20 | Creatinine sensor based on a molecularly imprinted polymer-modified hanging mercury drop eleetrode显示文摘 | Dhana L Bhim B P Piyush S S | 2006 | Talanta2006，，70： | 1 |
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