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| 1 | Experimental demonstration of coherent photonic neural computing based on a Fabry–Perot laser with a saturable absorber显示文摘As Moore’s law has reached its limits,it is becoming increasingly difficult for traditional computing architectures to meet the demands of continued growth in computing power.Photonic neural computing has become a promising approach to overcome the von Neuman bottleneck.However,while photonic neural networks are good at linear computing,it is difficult to achieve nonlinear computing.Here,we propose and experimentally demonstrate a coherent photonic spiking neural network consisting of Mach–Zehnder modulators(MZMs)as the synapse and an integrated quantum-well Fabry–Perot laser with a saturable absorber(FP-SA)as the photonic spiking neuron.Both linear computation and nonlinear computation are realized in the experiment.In such a coherent architecture,two presynaptic signals are modulated and weighted with two intensity modulation MZMs through the same optical carrier.The nonlinear neuron-like dynamics including temporal integration,threshold,and refractory period are successfully demonstrated.Besides,the effects of frequency detuning on the nonlinear neuron-like dynamics are also explored,and the frequency detuning condition is revealed.The proposed hardware architecture plays a foundational role in constructing a large-scale coherent photonic spiking neural network. | DIANZHUANG ZHENG SHUIYING XIANG XINGXING GUO YAHUI ZHANG BILING GU HONGJI WANG ZHENZHEN XU XIAOJUN ZHU YUECHUN SHI YUE HAO | 2023 | Photonics Research2023，11，1： | 2 |
| 2 | rAd/p53不同给药途径治疗人类结肠癌荷瘤鼠模型p53导入效率的在体评价(英文)显示文摘Objective: To evaluate transduction efficiency with recombinant adenovirus-mediated p53 (rAd/p53) therapy in a human colon cancer mouse model by intra-tumoral injection and intra-arterial delivery. Methods: The tumor pieces of human colon cancer SW480 were implanted in the livers of 45 nude mice. These mice were administrated with rAd/p53 by intratumoral injection and intra-arterial delivery. After 24 h, 48 h and 72 h rAd/p53 administration, 5 mice each group were killed with over anesthesia and their livers were removed. P53 expression and apoptosis of tumor and liver were assessed. Results: P53 expression and apoptosis of intratumoral administration group was higher than tail vein group and control group. Apoptosis and p53 expression of livers in three groups had no significant difference. Conclusion: p53 gene transduction efficiency and anticancer effect of rAd/p53 is much better by intra-tumoral injection than intra-arterial delivery. | Qi Xie Biling Liang Jing Zhang Qihua Yang Xiongfei Gu Jing Xu Mingwang Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，12： | 0 |
| 3 | Nonlinear neural computation in an integrated FP-SA spiking neuron subject to incoherent dual-wavelength optical pulse injections显示文摘Photonic nonlinear computation is the critical cornerstone of photonic neuromorphic computing.As one of the key information function units in the photonic spiking neural networks,the photonic spiking neurons are responsible for the nonlinear computation of the network.Recently,the neuron-like nonlinear computation of the photonic spiking neuron has attracted considerable attention. | Ziwei SONG Shuiying XIANG Xingxing GUO Shuang GAO Biling GU Dianzhuang ZHENG Xiangfei CHEN Yuechun SHI | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 4 | Experimental and numerical demonstration of hierarchical time-delay reservoir computing based on cascaded VCSELs with feedback and multiple injections显示文摘In this paper,we propose and demonstrate experimentally and numerically a hierarchical timedelay optical reservoir computing(RC)system based on cascaded vertical-cavity surface-emitting lasers(VCSELs)with feedback and multiple injections.The prediction performance characteristics of the hierarchical time-delay RC system based on cascaded VCSELs under different reservoir layers are compared.Evidently,the prediction performance of the hierarchical time-delay RC system is first improved and saturates as the number of reservoir layers increases.Besides,the impacts of key factors on predicting the hierarchical time-delay RC system are also analyzed in detail experimentally and numerically.This proposed hierarchical time-delay RC system based on VCSELs is useful for the further development of RC systems and may be beneficial to improve the ability of RC systems to solve more complex problems. | Xingxing GUO Shuiying XIANG Xingyu CAO Biling GU | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
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